U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal epidermal protein expression

MedGen UID:
1842057
•Concept ID:
C5826488
•
Finding
HPO: HP:0034573

Professional guidelines

PubMed

EGFR Signaling Is Overactive in Pachyonychia Congenita: Effective Treatment with Oral Erlotinib.
Basset J, Marchal L, Hovnanian A
J Invest Dermatol 2023 Feb;143(2):294-304.e8. Epub 2022 Sep 16 doi: 10.1016/j.jid.2022.08.045. PMID: 36116508
Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment.
Hailing T, Yonghong P, Yufeng Z, Haitao T
J Control Release 2022 Sep;349:592-605. Epub 2022 Jul 22 doi: 10.1016/j.jconrel.2022.07.018. PMID: 35872181
Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.
Vahlquist A, Fischer J, Törmä H
Am J Clin Dermatol 2018 Feb;19(1):51-66. doi: 10.1007/s40257-017-0313-x. PMID: 28815464Free PMC Article

Recent clinical studies

Etiology

Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.
Zhang Q, Zhang Z, He X, Liu Z, Shen L, Long C, Wei G, Liu X
J Pediatr Urol 2023 Oct;19(5):581.e1-581.e6. Epub 2023 May 13 doi: 10.1016/j.jpurol.2023.05.006. PMID: 37246119
Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies.
Vacchi E, Lazzarini E, Pinton S, Chiaro G, Disanto G, Marchi F, Robert T, Staedler C, Galati S, Gobbi C, Barile L, Kaelin-Lang A, Melli G
Brain 2022 Aug 27;145(8):2755-2768. doi: 10.1093/brain/awac161. PMID: 35485527
The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults.
Renert-Yuval Y, Del Duca E, Pavel AB, Fang M, Lefferdink R, Wu J, Diaz A, Estrada YD, Canter T, Zhang N, Wagner A, Chamlin S, Krueger JG, Guttman-Yassky E, Paller AS
J Allergy Clin Immunol 2021 Jul;148(1):148-163. Epub 2021 Jan 13 doi: 10.1016/j.jaci.2021.01.001. PMID: 33453290Free PMC Article
Beclin1 in psoriasis: an immunohistochemical study.
Amer AS, Samaka RM, Moftah NH
Clin Exp Dermatol 2021 Jul;46(5):851-860. Epub 2021 Feb 5 doi: 10.1111/ced.14554. PMID: 33405299
Epigenetics in the pathogenesis and pathophysiology of psoriasis vulgaris.
Trowbridge RM, Pittelkow MR
J Drugs Dermatol 2014 Feb;13(2):111-8. PMID: 24509958

Diagnosis

Keratinocytes: An Enigmatic Factor in Atopic Dermatitis.
Das P, Mounika P, Yellurkar ML, Prasanna VS, Sarkar S, Velayutham R, Arumugam S
Cells 2022 May 19;11(10) doi: 10.3390/cells11101683. PMID: 35626720Free PMC Article
Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer.
Fu Y, Zhang Y, Lei Z, Liu T, Cai T, Wang A, Du W, Zeng Y, Zhu J, Liu Z, Huang JA
J Hematol Oncol 2020 Dec 7;13(1):169. doi: 10.1186/s13045-020-01009-7. PMID: 33287873Free PMC Article
Low-grade developmental and epilepsy associated brain tumors: a critical update 2020.
Slegers RJ, Blumcke I
Acta Neuropathol Commun 2020 Mar 9;8(1):27. doi: 10.1186/s40478-020-00904-x. PMID: 32151273Free PMC Article
Use of Tape Strips to Detect Immune and Barrier Abnormalities in the Skin of Children With Early-Onset Atopic Dermatitis.
Guttman-Yassky E, Diaz A, Pavel AB, Fernandes M, Lefferdink R, Erickson T, Canter T, Rangel S, Peng X, Li R, Estrada Y, Xu H, Krueger JG, Paller AS
JAMA Dermatol 2019 Dec 1;155(12):1358-1370. doi: 10.1001/jamadermatol.2019.2983. PMID: 31596431Free PMC Article
Thermally activated TRPV3 channels.
Luo J, Hu H
Curr Top Membr 2014;74:325-64. doi: 10.1016/B978-0-12-800181-3.00012-9. PMID: 25366242

Therapy

Nutrition and Psoriasis.
Kanda N, Hoashi T, Saeki H
Int J Mol Sci 2020 Jul 29;21(15) doi: 10.3390/ijms21155405. PMID: 32751360Free PMC Article
Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation.
Thatikonda S, Pooladanda V, Sigalapalli DK, Godugu C
Cell Death Dis 2020 Jan 10;11(1):21. doi: 10.1038/s41419-019-2212-y. PMID: 31924750Free PMC Article
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.
Guttman-Yassky E, Bissonnette R, Ungar B, Suárez-Fariñas M, Ardeleanu M, Esaki H, Suprun M, Estrada Y, Xu H, Peng X, Silverberg JI, Menter A, Krueger JG, Zhang R, Chaudhry U, Swanson B, Graham NMH, Pirozzi G, Yancopoulos GD, D Hamilton JD
J Allergy Clin Immunol 2019 Jan;143(1):155-172. Epub 2018 Sep 5 doi: 10.1016/j.jaci.2018.08.022. PMID: 30194992
EGFR-TKIs resistance via EGFR-independent signaling pathways.
Liu Q, Yu S, Zhao W, Qin S, Chu Q, Wu K
Mol Cancer 2018 Feb 19;17(1):53. doi: 10.1186/s12943-018-0793-1. PMID: 29455669Free PMC Article
A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903.
Moosbrugger-Martinz V, Schmuth M, Dubrac S
Methods Mol Biol 2017;1559:91-106. doi: 10.1007/978-1-4939-6786-5_8. PMID: 28063040

Prognosis

A TP63 mutation identified in a Han Chinese family with ectodermal dysplasia.
Zhou X, Zhang C, Fan L, Wu S, Yao S, Wang L, Zhong W, Ma L, Pan Y
Arch Oral Biol 2023 Aug;152:105731. Epub 2023 May 18 doi: 10.1016/j.archoralbio.2023.105731. PMID: 37257258
Defective cathepsin Z affects EGFR expression and causes autosomal dominant palmoplantar keratoderma.
Malovitski K, Sarig O, Feller Y, Bergson S, Assaf S, Mohamad J, Pavlovsky M, Giladi M, Sprecher E
Br J Dermatol 2023 Aug 24;189(3):302-311. doi: 10.1093/bjd/ljad167. PMID: 37210216
Use of Tape Strips to Detect Immune and Barrier Abnormalities in the Skin of Children With Early-Onset Atopic Dermatitis.
Guttman-Yassky E, Diaz A, Pavel AB, Fernandes M, Lefferdink R, Erickson T, Canter T, Rangel S, Peng X, Li R, Estrada Y, Xu H, Krueger JG, Paller AS
JAMA Dermatol 2019 Dec 1;155(12):1358-1370. doi: 10.1001/jamadermatol.2019.2983. PMID: 31596431Free PMC Article
AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer.
Cao W, Li J, Hao Q, Vadgama JV, Wu Y
Breast Cancer Res 2019 Feb 21;21(1):29. doi: 10.1186/s13058-019-1107-2. PMID: 30791936Free PMC Article
HER2 testing in gastric cancer: An update.
Abrahao-Machado LF, Scapulatempo-Neto C
World J Gastroenterol 2016 May 21;22(19):4619-25. doi: 10.3748/wjg.v22.i19.4619. PMID: 27217694Free PMC Article

Clinical prediction guides

RAB25 coordinates filaggrin-containing keratohyalin granule maturation and affects atopic dermatitis severity.
Jeong H, Lee N, Uhm C, Cho K, Oh H, Oh Y, Zhang K, Kim HL, Goldenring JR, Lim KM, Park CO, Nam KT
Allergy 2023 Apr;78(4):1007-1019. Epub 2022 Nov 21 doi: 10.1111/all.15582. PMID: 36383036
Beclin1 in psoriasis: an immunohistochemical study.
Amer AS, Samaka RM, Moftah NH
Clin Exp Dermatol 2021 Jul;46(5):851-860. Epub 2021 Feb 5 doi: 10.1111/ced.14554. PMID: 33405299
Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation.
Thatikonda S, Pooladanda V, Sigalapalli DK, Godugu C
Cell Death Dis 2020 Jan 10;11(1):21. doi: 10.1038/s41419-019-2212-y. PMID: 31924750Free PMC Article
Periderm: Life-cycle and function during orofacial and epidermal development.
Hammond NL, Dixon J, Dixon MJ
Semin Cell Dev Biol 2019 Jul;91:75-83. Epub 2017 Aug 10 doi: 10.1016/j.semcdb.2017.08.021. PMID: 28803895
A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903.
Moosbrugger-Martinz V, Schmuth M, Dubrac S
Methods Mol Biol 2017;1559:91-106. doi: 10.1007/978-1-4939-6786-5_8. PMID: 28063040

Recent systematic reviews

Neurotrophic factors, childhood trauma and psychiatric disorders: A systematic review of genetic, biochemical, cognitive and imaging studies to identify potential biomarkers.
Di Benedetto MG, Scassellati C, Cattane N, Riva MA, Cattaneo A
J Affect Disord 2022 Jul 1;308:76-88. Epub 2022 Apr 2 doi: 10.1016/j.jad.2022.03.071. PMID: 35378148
Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis.
Yadav K, Singh D, Singh MR
Int J Biol Macromol 2018 Oct 15;118(Pt B):1796-1810. Epub 2018 Jul 11 doi: 10.1016/j.ijbiomac.2018.07.021. PMID: 30017989
The HLA-B*15:02 polymorphism and Tegretol(®)-induced serious cutaneous reactions in epilepsy: An updated systematic review and meta-analysis.
Chouchi M, Kaabachi W, Tizaoui K, Daghfous R, Aidli SE, Hila L
Rev Neurol (Paris) 2018 May;174(5):278-291. doi: 10.1016/j.neurol.2017.11.006. PMID: 29685430
Prognostic value of c-MET in head and neck cancer: A systematic review and meta-analysis of aggregate data.
Szturz P, Budíková M, Vermorken JB, Horová I, Gál B, Raymond E, de Gramont A, Faivre S
Oral Oncol 2017 Nov;74:68-76. Epub 2017 Sep 27 doi: 10.1016/j.oraloncology.2017.09.009. PMID: 29103754
Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth factor 2 (HER2): a systematic review and economic analysis.
Fleeman N, Bagust A, Boland A, Dickson R, Dundar Y, Moonan M, Oyee J, Blundell M, Davis H, Armstrong A, Thorp N
Health Technol Assess 2011;15(42):1-93, iii-iv. doi: 10.3310/hta15420. PMID: 22152751Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...