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Metaplastic Carcinoma

MedGen UID:
224759
•Concept ID:
C1266089
•
Neoplastic Process
Synonym: Metaplastic carcinoma
SNOMED CT: Metaplastic carcinoma (128705006)

Definition

A general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation. [from NCI]

Professional guidelines

PubMed

Clinical and Demographic Factors, Treatment Patterns, and Overall Survival Associated With Rare Triple-Negative Breast Carcinomas in the US.
Elimimian EB, Samuel TA, Liang H, Elson L, Bilani N, Nahleh ZA
JAMA Netw Open 2021 Apr 1;4(4):e214123. doi: 10.1001/jamanetworkopen.2021.4123. PMID: 33844001Free PMC Article
Management and prognosis of pure primary squamous cell carcinoma of the breast.
Benoist P, Mureau A, Joueidi Y, Arbion F, Vilde A, Body G, Michenet P, Leveque J, Ouldamer L
J Gynecol Obstet Hum Reprod 2018 Sep;47(7):275-280. Epub 2018 Jun 27 doi: 10.1016/j.jogoh.2018.06.007. PMID: 29959086
Metaplastic carcinoma of the breast: Treatment, results and prognostic factors based on international literature.
Sanguinetti A, Lucchini R, Santoprete S, Farabi R, Fioriti L, Bistoni G, Triola R, Avenia N
Ann Ital Chir 2014 Mar-Apr;85(2):109-13. PMID: 24195912

Recent clinical studies

Etiology

Metaplastic breast carcinoma: Analysis of clinical and pathologic features, a five-year study.
Chaudhary D, Balhara K, Mandal S, Mallya V, Tomar R, Khurana N, Bains L
J Cancer Res Ther 2023 Jul-Sep;19(5):1226-1230. doi: 10.4103/jcrt.jcrt_1229_21. PMID: 37787287
Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature.
Papatheodoridi A, Papamattheou E, Marinopoulos S, Ntanasis-Stathopoulos I, Dimitrakakis C, Giannos A, Kaparelou M, Liontos M, Dimopoulos MA, Zagouri F
Med Sci (Basel) 2023 May 19;11(2) doi: 10.3390/medsci11020035. PMID: 37218987Free PMC Article
Metaplastic Breast Carcinoma Revisited; Subtypes Determine Outcomes: Comprehensive Pathologic, Clinical, and Molecular Review.
Khoury T
Surg Pathol Clin 2022 Mar;15(1):159-174. Epub 2022 Jan 31 doi: 10.1016/j.path.2021.11.011. PMID: 35236632
Spindle cell lesions of the breast: a diagnostic approach.
Rakha EA, Brogi E, Castellano I, Quinn C
Virchows Arch 2022 Jan;480(1):127-145. Epub 2021 Jul 29 doi: 10.1007/s00428-021-03162-x. PMID: 34322734Free PMC Article
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Diagnosis

TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.
Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Spindle cell lesions of the breast: a diagnostic approach.
Rakha EA, Brogi E, Castellano I, Quinn C
Virchows Arch 2022 Jan;480(1):127-145. Epub 2021 Jul 29 doi: 10.1007/s00428-021-03162-x. PMID: 34322734Free PMC Article
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Metaplastic carcinoma of the breast.
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252

Therapy

Breast Cancer and Secondary Cancer Recurrences After Autologous Tissue Reconstruction.
Early AP, Moon W
Clin Breast Cancer 2021 Feb;21(1):e96-e101. Epub 2020 Aug 3 doi: 10.1016/j.clbc.2020.07.015. PMID: 32855081
Radiation-Associated Primary Osteosarcoma of the Breast.
Bartlett H, Elghobashy M, Deshmukh N, Rao R, Shaaban AM
Pathobiology 2020;87(5):322-326. Epub 2020 Sep 11 doi: 10.1159/000509580. PMID: 32920553
Metaplastic carcinoma of the breast: Prognosis and response to systemic treatment in metastatic disease.
Takala S, Heikkilä P, Nevanlinna H, Blomqvist C, Mattson J
Breast J 2019 May;25(3):418-424. Epub 2019 Mar 29 doi: 10.1111/tbj.13234. PMID: 30925636
Metaplastic carcinoma of the breast with mesenchymal differentiation (carcinosarcoma). A unique presentation of an aggressive malignancy and literature review.
Salemis NS
Breast Dis 2018;37(3):169-175. doi: 10.3233/BD-170313. PMID: 29504519
Metaplastic carcinoma of the breast.
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252

Prognosis

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature.
Papatheodoridi A, Papamattheou E, Marinopoulos S, Ntanasis-Stathopoulos I, Dimitrakakis C, Giannos A, Kaparelou M, Liontos M, Dimopoulos MA, Zagouri F
Med Sci (Basel) 2023 May 19;11(2) doi: 10.3390/medsci11020035. PMID: 37218987Free PMC Article
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Metaplastic Breast Carcinoma: Update on Histopathology and Molecular Alterations.
McMullen ER, Zoumberos NA, Kleer CG
Arch Pathol Lab Med 2019 Dec;143(12):1492-1496. doi: 10.5858/arpa.2019-0396-RA. PMID: 31765246
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Metaplastic carcinoma of the breast.
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252

Clinical prediction guides

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.
Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Recent systematic reviews

Basal cell carcinosarcoma: a systematic review and reappraisal of its challenges and the role of Mohs surgery.
Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451
Carcinosarcomas of the esophagus: systematic review of a rare nosologic entity.
Schizas D, Mastoraki A, Bagias G, Ioannidi M, Kanavidis P, Moris D, Tsilimigras DI, Spartalis E, Arkadopoulos N, Liakakos T
J BUON 2018 Sep-Oct;23(5):1432-1438. PMID: 30570870

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