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Lung occult squamous cell carcinoma

MedGen UID:
235400
•Concept ID:
C1335100
•
Neoplastic Process
Synonyms: lung occult squamous cell carcinoma; Occult Lung Squamous Cell Carcinoma; Occult Squamous Cell Carcinoma of Lung; occult squamous cell carcinoma of lung; Occult Squamous Cell Carcinoma of the Lung; occult squamous cell carcinoma of the lung; Occult Squamous Cell Lung Carcinoma; occult squamous cell lung carcinoma
 
Monarch Initiative: MONDO:0003904

Definition

A squamous cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung occult squamous cell carcinoma

Professional guidelines

PubMed

Management of field change in actinic keratosis.
Vatve M, Ortonne JP, Birch-Machin MA, Gupta G
Br J Dermatol 2007 Dec;157 Suppl 2:21-4. doi: 10.1111/j.1365-2133.2007.08268.x. PMID: 18067627
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
Bronchoscopic localization and treatment of occult lung cancer.
Edell ES, Cortese DA
Chest 1989 Oct;96(4):919-21. doi: 10.1378/chest.96.4.919. PMID: 2529106

Recent clinical studies

Etiology

The predictive value of the change of the number of pixels under different CT value intervals in the CT-occult central lung squamous cell carcinoma and squamous epithelial precancerous lesions.
Zhou J, Yu B, Guo P, Wang S
BMC Pulm Med 2023 Nov 3;23(1):426. doi: 10.1186/s12890-023-02732-w. PMID: 37924039Free PMC Article
Prevalence, molecular markers, and outcome of bronchial squamous carcinoma in situ in high-risk subjects.
Jonsson S, Franklin WA, Varella-Garcia M, Kennedy TC, Merrick D, Matney KD, Oskarsdottir GN, Saemundsson A, Keith RL, Bunn PA, Miller YE
APMIS 2023 Oct;131(10):513-527. Epub 2023 Aug 23 doi: 10.1111/apm.13345. PMID: 37608782
Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer.
Haque W, Singh A, Park HS, Teh BS, Butler EB, Zeng M, Lin SH, Welsh JW, Chang JY, Verma V
Acta Oncol 2022 Apr;61(4):403-408. Epub 2021 Dec 16 doi: 10.1080/0284186X.2021.2012253. PMID: 34913815
Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study.
Wu LL, Li CW, Lin WK, Qiu LH, Xie D
BMC Cancer 2021 Sep 9;21(1):1009. doi: 10.1186/s12885-021-08741-4. PMID: 34496775Free PMC Article
Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project.
Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Yamagata Z, Ninomiya T, Muto K, Kiyohara Y, Matsuda K, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group, Tamakoshi A
J Epidemiol 2017 Mar;27(3S):S49-S57. Epub 2017 Feb 13 doi: 10.1016/j.je.2016.12.010. PMID: 28202209Free PMC Article

Diagnosis

Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study.
Wu LL, Li CW, Lin WK, Qiu LH, Xie D
BMC Cancer 2021 Sep 9;21(1):1009. doi: 10.1186/s12885-021-08741-4. PMID: 34496775Free PMC Article
Cervical lymph node metastases of squamous cell carcinoma from an unknown primary.
Jereczek-Fossa BA, Jassem J, Orecchia R
Cancer Treat Rev 2004 Apr;30(2):153-64. doi: 10.1016/j.ctrv.2003.10.001. PMID: 15023433
A therapeutic approach to roentgenographically occult squamous cell carcinoma of the lung.
Fujimura S, Sakurada A, Sagawa M, Saito Y, Takahashi H, Tanita T, Ono S, Matsumura S, Kondo T, Sato M
Cancer 2000 Dec 1;89(11 Suppl):2445-8. doi: 10.1002/1097-0142(20001201)89:11+<2445::aid-cncr19>3.3.co;2-m. PMID: 11147623
Bronchoscopic localization and treatment of occult lung cancer.
Edell ES, Cortese DA
Chest 1989 Oct;96(4):919-21. doi: 10.1378/chest.96.4.919. PMID: 2529106
Squamous cell carcinoma of the lung: an update.
Carter D
Semin Diagn Pathol 1985 Nov;2(4):226-34. PMID: 3916556

Therapy

Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer.
Haque W, Singh A, Park HS, Teh BS, Butler EB, Zeng M, Lin SH, Welsh JW, Chang JY, Verma V
Acta Oncol 2022 Apr;61(4):403-408. Epub 2021 Dec 16 doi: 10.1080/0284186X.2021.2012253. PMID: 34913815
Management of field change in actinic keratosis.
Vatve M, Ortonne JP, Birch-Machin MA, Gupta G
Br J Dermatol 2007 Dec;157 Suppl 2:21-4. doi: 10.1111/j.1365-2133.2007.08268.x. PMID: 18067627
Photodynamic therapy for early stage squamous cell carcinoma of the lung.
Cortese DA, Edell ES, Kinsey JH
Mayo Clin Proc 1997 Jul;72(7):595-602. doi: 10.1016/S0025-6196(11)63563-5. PMID: 9212759
Photodynamic therapy and/or external beam radiation therapy for roentgenologically occult lung cancer.
Imamura S, Kusunoki Y, Takifuji N, Kudo S, Matsui K, Masuda N, Takada M, Negoro S, Ryu S, Fukuoka M
Cancer 1994 Mar 15;73(6):1608-14. doi: 10.1002/1097-0142(19940315)73:6<1608::aid-cncr2820730611>3.0.co;2-1. PMID: 8156487
Bronchoscopic localization and treatment of occult lung cancer.
Edell ES, Cortese DA
Chest 1989 Oct;96(4):919-21. doi: 10.1378/chest.96.4.919. PMID: 2529106

Prognosis

The predictive value of the change of the number of pixels under different CT value intervals in the CT-occult central lung squamous cell carcinoma and squamous epithelial precancerous lesions.
Zhou J, Yu B, Guo P, Wang S
BMC Pulm Med 2023 Nov 3;23(1):426. doi: 10.1186/s12890-023-02732-w. PMID: 37924039Free PMC Article
Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study.
Wu LL, Li CW, Lin WK, Qiu LH, Xie D
BMC Cancer 2021 Sep 9;21(1):1009. doi: 10.1186/s12885-021-08741-4. PMID: 34496775Free PMC Article
Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project.
Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Yamagata Z, Ninomiya T, Muto K, Kiyohara Y, Matsuda K, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group, Tamakoshi A
J Epidemiol 2017 Mar;27(3S):S49-S57. Epub 2017 Feb 13 doi: 10.1016/j.je.2016.12.010. PMID: 28202209Free PMC Article
Cervical lymph node metastases of squamous cell carcinoma from an unknown primary.
Jereczek-Fossa BA, Jassem J, Orecchia R
Cancer Treat Rev 2004 Apr;30(2):153-64. doi: 10.1016/j.ctrv.2003.10.001. PMID: 15023433
Squamous cell carcinoma of the lung: an update.
Carter D
Semin Diagn Pathol 1985 Nov;2(4):226-34. PMID: 3916556

Clinical prediction guides

The predictive value of the change of the number of pixels under different CT value intervals in the CT-occult central lung squamous cell carcinoma and squamous epithelial precancerous lesions.
Zhou J, Yu B, Guo P, Wang S
BMC Pulm Med 2023 Nov 3;23(1):426. doi: 10.1186/s12890-023-02732-w. PMID: 37924039Free PMC Article
Prevalence, molecular markers, and outcome of bronchial squamous carcinoma in situ in high-risk subjects.
Jonsson S, Franklin WA, Varella-Garcia M, Kennedy TC, Merrick D, Matney KD, Oskarsdottir GN, Saemundsson A, Keith RL, Bunn PA, Miller YE
APMIS 2023 Oct;131(10):513-527. Epub 2023 Aug 23 doi: 10.1111/apm.13345. PMID: 37608782
Prevalence and Predictability of Occult Satellite Nodules in Clinical Stage Ia Non-small Cell Lung Cancer following Lobectomy.
Kneuertz PJ, Abdel-Rasoul M, D'Souza DM, Moffatt-Bruce SD, Merritt RE
Clin Lung Cancer 2023 May;24(3):e134-e140. Epub 2022 Dec 27 doi: 10.1016/j.cllc.2022.12.009. PMID: 36682930Free PMC Article
Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer.
Haque W, Singh A, Park HS, Teh BS, Butler EB, Zeng M, Lin SH, Welsh JW, Chang JY, Verma V
Acta Oncol 2022 Apr;61(4):403-408. Epub 2021 Dec 16 doi: 10.1080/0284186X.2021.2012253. PMID: 34913815
Spread Through Air Spaces (STAS) in Non-Small Cell Lung Carcinoma: Evidence Supportive of an In Vivo Phenomenon.
Gross DJ, Hsieh MS, Li Y, Dux J, Rekhtman N, Jones DR, Travis WD, Adusumilli PS
Am J Surg Pathol 2021 Nov 1;45(11):1509-1515. doi: 10.1097/PAS.0000000000001788. PMID: 34366424Free PMC Article

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