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Vulvar Melanocytic Neoplasm

MedGen UID:
276993
•Concept ID:
C1520090
•
Neoplastic Process

Definition

A neoplasm that originates from melanocytes and arises from the vulva. This category includes congenital and acquired melanocytic nevus, blue nevus, dysplastic melanocytic nevus, atypical melanocytic nevus, genital type, and melanoma. [from NCI]

Professional guidelines

PubMed

Management of melanomas of the gynaecological tract.
Nobbenhuis MA, Lalondrelle S, Larkin J, Banerjee S
Curr Opin Oncol 2014 Sep;26(5):508-13. doi: 10.1097/CCO.0000000000000104. PMID: 25046205
Management of primary melanoma of the female urogenital tract.
Piura B
Lancet Oncol 2008 Oct;9(10):973-81. doi: 10.1016/S1470-2045(08)70254-7. PMID: 19071254

Recent clinical studies

Etiology

Different clinico-pathological and prognostic features of vulvar, vaginal, and cervical melanomas.
Wu Y, Li H, Tan L, Lai Y, Li Z
Hum Pathol 2023 Jan;131:87-97. Epub 2022 Nov 10 doi: 10.1016/j.humpath.2022.11.002. PMID: 36370822
Nonsquamous Lesions of the Vulvar Skin and Subcutaneous Tissue: A Review (Part 1).
Rastegar S, Heller DS
J Low Genit Tract Dis 2021 Oct 1;25(4):303-311. doi: 10.1097/LGT.0000000000000624. PMID: 34542086
An Update on Mucosal Melanoma: Future Directions.
Goldemberg DC, Thuler LCS, de Melo AC
Acta Dermatovenerol Croat 2019 Mar;27(1):11-15. PMID: 31032785
Melanocytic lesions - Staying out of trouble.
Brenn T
Ann Diagn Pathol 2018 Dec;37:91-102. Epub 2018 Sep 27 doi: 10.1016/j.anndiagpath.2018.09.010. PMID: 30312883
Vulvar and Anal Intraepithelial Neoplasia: Terminology, Diagnosis, and Ancillary Studies.
Yang EJ, Kong CS, Longacre TA
Adv Anat Pathol 2017 May;24(3):136-150. doi: 10.1097/PAP.0000000000000149. PMID: 28398952

Diagnosis

An Update on Mucosal Melanoma: Future Directions.
Goldemberg DC, Thuler LCS, de Melo AC
Acta Dermatovenerol Croat 2019 Mar;27(1):11-15. PMID: 31032785
Melanocytic lesions - Staying out of trouble.
Brenn T
Ann Diagn Pathol 2018 Dec;37:91-102. Epub 2018 Sep 27 doi: 10.1016/j.anndiagpath.2018.09.010. PMID: 30312883
Vulvar Neoplasms, Benign and Malignant.
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
Vulvar and Anal Intraepithelial Neoplasia: Terminology, Diagnosis, and Ancillary Studies.
Yang EJ, Kong CS, Longacre TA
Adv Anat Pathol 2017 May;24(3):136-150. doi: 10.1097/PAP.0000000000000149. PMID: 28398952
Atypical genital nevus.
Brenn T
Arch Pathol Lab Med 2011 Mar;135(3):317-20. doi: 10.5858/2009-0382-RA.1. PMID: 21366454

Therapy

Clinical and Dermoscopic Features of Vulvar Melanosis Over the Last 20 Years.
De Giorgi V, Gori A, Salvati L, Scarfì F, Maida P, Trane L, Silvestri F, Portelli F, Venturi F, Covarelli P, Massi D
JAMA Dermatol 2020 Nov 1;156(11):1185-1191. doi: 10.1001/jamadermatol.2020.2528. PMID: 32785609Free PMC Article
Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events?
Serra MC, Menicanti C, Pennacchioli E, Tosti G
An Bras Dermatol 2014 Sep-Oct;89(5):806-7. doi: 10.1590/abd1806-4841.20143058. PMID: 25184923Free PMC Article
Dermo Beta Brachytherapy with 188Re in extramammary Paget's disease.
Carrozzo AM, Cipriani C, Donati P, Muscardin L, Sedda AF
G Ital Dermatol Venereol 2014 Feb;149(1):115-21. PMID: 24566572
Melanocytic proliferations associated with lichen sclerosus in adolescence.
Bussen SS
Arch Gynecol Obstet 2009 Dec;280(6):1039-40. Epub 2009 Mar 28 doi: 10.1007/s00404-009-1049-5. PMID: 19330343
Malignant melanoma with adjacent intraepidermal proliferation.
Seiji M, Takahashi M
Tohoku J Exp Med 1974 Oct;114(2):93-107. doi: 10.1620/tjem.114.93. PMID: 4612877

Prognosis

Different clinico-pathological and prognostic features of vulvar, vaginal, and cervical melanomas.
Wu Y, Li H, Tan L, Lai Y, Li Z
Hum Pathol 2023 Jan;131:87-97. Epub 2022 Nov 10 doi: 10.1016/j.humpath.2022.11.002. PMID: 36370822
An Update on Mucosal Melanoma: Future Directions.
Goldemberg DC, Thuler LCS, de Melo AC
Acta Dermatovenerol Croat 2019 Mar;27(1):11-15. PMID: 31032785
Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review.
Murzaku EC, Penn LA, Hale CS, Pomeranz MK, Polsky D
J Am Acad Dermatol 2014 Dec;71(6):1241-9. Epub 2014 Sep 27 doi: 10.1016/j.jaad.2014.08.019. PMID: 25267379
Management of melanomas of the gynaecological tract.
Nobbenhuis MA, Lalondrelle S, Larkin J, Banerjee S
Curr Opin Oncol 2014 Sep;26(5):508-13. doi: 10.1097/CCO.0000000000000104. PMID: 25046205
Pigmented lesions of the vulva.
Rock B
Dermatol Clin 1992 Apr;10(2):361-70. PMID: 1606765

Clinical prediction guides

Epidemiological profile of mucosal melanoma in Brazil.
Cohen Goldemberg D, de Melo AC, de Melo Pino LC, Thuler LCS
Sci Rep 2020 Jan 16;10(1):505. doi: 10.1038/s41598-019-57253-6. PMID: 31949210Free PMC Article
A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker.
Heinzelmann-Schwarz VA, Nixdorf S, Valadan M, Diczbalis M, Olivier J, Otton G, Fedier A, Hacker NF, Scurry JP
Int J Mol Med 2014 Apr;33(4):784-94. Epub 2014 Feb 14 doi: 10.3892/ijmm.2014.1659. PMID: 24535703Free PMC Article
Dermatopathology updates on melanocytic lesions.
Cheung WL, Smoller BR
Dermatol Clin 2012 Oct;30(4):617-22, vi. Epub 2012 Aug 3 doi: 10.1016/j.det.2012.06.014. PMID: 23021049
Vulvar melanocytic nevi: a dermoscopic investigation.
Virgili A, Zampino MR, Marzola A, Corazza M
Dermatology 2010 Aug;221(1):55-62. Epub 2010 May 13 doi: 10.1159/000278259. PMID: 20484874
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416

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