U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Non-Neoplastic Oral Cavity Disorder

MedGen UID:
277428
•Concept ID:
C1335025
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the oral cavity. Representative examples include inflammation, fibroepithelial polyp, and cleft palate. [from NCI]

Professional guidelines

PubMed

Impact of the Milan System for Reporting Salivary Gland Cytology on risk assessment when used in routine practice in a real-time setting.
Manucha V, Gonzalez MF, Akhtar I
J Am Soc Cytopathol 2021 Mar-Apr;10(2):208-215. Epub 2020 Aug 15 doi: 10.1016/j.jasc.2020.08.005. PMID: 32893181
Fluorescence visualization improves the detection of oral, potentially malignant, disorders in population screening.
Simonato LE, Tomo S, Scarparo Navarro R, Balbin Villaverde AGJ
Photodiagnosis Photodyn Ther 2019 Sep;27:74-78. Epub 2019 May 19 doi: 10.1016/j.pdpdt.2019.05.017. PMID: 31116999
Sialoendoscopy for diagnosis and treatment of non-neoplastic obstruction in the salivary glands.
Danquart J, Wagner N, Arndal H, Homøe P
Dan Med Bull 2011 Feb;58(2):A4232. PMID: 21299921

Recent clinical studies

Etiology

Salivary gland tumours: an epidemiological review of non-neoplastic and neoplastic pathology.
Mckenzie J, Lockyer J, Singh T, Nguyen E
Br J Oral Maxillofac Surg 2023 Jan;61(1):12-18. Epub 2022 Dec 9 doi: 10.1016/j.bjoms.2022.11.281. PMID: 36623970
Cystic lesions of the parotid gland: radiologic-pathologic correlation according to the latest World Health Organization 2017 Classification of Head and Neck Tumours.
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102
Folate intake and risk of oral and pharyngeal cancer.
Pelucchi C, Talamini R, Negri E, Levi F, Conti E, Franceschi S, La Vecchia C
Ann Oncol 2003 Nov;14(11):1677-81. doi: 10.1093/annonc/mdg448. PMID: 14581278

Diagnosis

CT and MR imaging findings of non-neoplastic cystic lesions of the parotid gland.
Kato H, Kawaguchi M, Ando T, Aoki M, Kuze B, Matsuo M
Jpn J Radiol 2019 Sep;37(9):627-635. Epub 2019 Jul 27 doi: 10.1007/s11604-019-00858-8. PMID: 31352657
Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa.
Rosebush MS, Briody AN, Cordell KG
Head Neck Pathol 2019 Mar;13(1):47-55. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0980-9. PMID: 30671761Free PMC Article
Cystic lesions of the parotid gland: radiologic-pathologic correlation according to the latest World Health Organization 2017 Classification of Head and Neck Tumours.
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142
Parotid space: anatomic imaging.
Kanekar SG, Mannion K, Zacharia T, Showalter M
Otolaryngol Clin North Am 2012 Dec;45(6):1253-72. doi: 10.1016/j.otc.2012.08.011. PMID: 23153748
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859

Therapy

Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes.
Patil S, Bhat MY, Advani J, Mohan SV, Babu N, Datta KK, Subbannayya T, Rajagopalan P, Bhat FA, Al-Hebshi N, Sidransky D, Gowda H, Chatterjee A
Sci Rep 2021 Apr 30;11(1):9397. doi: 10.1038/s41598-021-88345-x. PMID: 33931671Free PMC Article
Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy.
Shivappa N, Hébert JR, Rosato V, Garavello W, Serraino D, La Vecchia C
Int J Cancer 2017 Aug 1;141(3):471-479. Epub 2017 May 9 doi: 10.1002/ijc.30711. PMID: 28340515Free PMC Article
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102
Folate intake and risk of oral and pharyngeal cancer.
Pelucchi C, Talamini R, Negri E, Levi F, Conti E, Franceschi S, La Vecchia C
Ann Oncol 2003 Nov;14(11):1677-81. doi: 10.1093/annonc/mdg448. PMID: 14581278
Selected micronutrients and oral and pharyngeal cancer.
Negri E, Franceschi S, Bosetti C, Levi F, Conti E, Parpinel M, La Vecchia C
Int J Cancer 2000 Apr 1;86(1):122-7. doi: 10.1002/(sici)1097-0215(20000401)86:1<122::aid-ijc19>3.0.co;2-2. PMID: 10728605

Prognosis

Histopathologic and clinical outcomes of Milan System categories "non-diagnostic" and "non-neoplastic" of salivary gland fine needle aspirations.
Johnson DN, Antic T, Reeves W, Mueller J, Lastra RR, Cipriani NA, Biernacka A
J Am Soc Cytopathol 2021 Jul-Aug;10(4):349-356. Epub 2021 Mar 19 doi: 10.1016/j.jasc.2021.03.001. PMID: 33867311
Prevalence of p53 dysregulations in feline oral squamous cell carcinoma and non-neoplastic oral mucosa.
Renzi A, De Bonis P, Morandi L, Lenzi J, Tinto D, Rigillo A, Bettini G, Bellei E, Sabattini S
PLoS One 2019;14(4):e0215621. Epub 2019 Apr 18 doi: 10.1371/journal.pone.0215621. PMID: 30998743Free PMC Article
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859
Matrix metalloproteinases and their inhibitors in non-neoplastic otorhinolaryngological disease.
De S, Fenton JE, Jones AS
J Laryngol Otol 2005 Jun;119(6):436-42. doi: 10.1258/0022215054273269. PMID: 15992468
High resolution ultrasound assessment of the parotid gland.
Howlett DC
Br J Radiol 2003 Apr;76(904):271-7. doi: 10.1259/bjr/33081866. PMID: 12711649

Clinical prediction guides

Comparison of PD-L1 Expression in Oral Squamous Cell Carcinoma and Premalignant Lesions of Oral Cavity.
Saeed S, Rauf F, Iqbal F, Khan AS, Khan AH, Alamgeer R
Asian Pac J Cancer Prev 2022 Dec 1;23(12):4039-4045. doi: 10.31557/APJCP.2022.23.12.4039. PMID: 36579984Free PMC Article
Neoplasms and non-neoplastic pathologies in the oral and maxillofacial regions in children and adolescents of a Brazilian population.
da Silva Barros CC, da Silva LP, Gonzaga AKG, de Medeiros AMC, de Souza LB, da Silveira ÉJD
Clin Oral Investig 2019 Apr;23(4):1587-1593. Epub 2018 Aug 24 doi: 10.1007/s00784-018-2581-0. PMID: 30143900
Agreement between clinical and histopathologic diagnoses and completeness of oral biopsy forms.
Mendez M, Haas AN, Rados PV, Sant'ana M Filho, Carrard VC
Braz Oral Res 2016 Aug 22;30(1):e94. doi: 10.1590/1807-3107BOR-2016.vol30.0094. PMID: 27556681
Folate intake and risk of oral and pharyngeal cancer.
Pelucchi C, Talamini R, Negri E, Levi F, Conti E, Franceschi S, La Vecchia C
Ann Oncol 2003 Nov;14(11):1677-81. doi: 10.1093/annonc/mdg448. PMID: 14581278
High resolution ultrasound assessment of the parotid gland.
Howlett DC
Br J Radiol 2003 Apr;76(904):271-7. doi: 10.1259/bjr/33081866. PMID: 12711649

Recent systematic reviews

Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review.
Feola T, Gianno F, De Angelis M, Colonnese C, Esposito V, Giangaspero F, Jaffrain-Rea ML
J Endocrinol Invest 2021 Oct;44(10):2103-2122. Epub 2021 May 3 doi: 10.1007/s40618-021-01577-6. PMID: 33939106Free PMC Article
Peripheral giant cell granuloma associated with dental implants: a systematic review.
Chrcanovic BR, Gomes CC, Gomez RS
J Stomatol Oral Maxillofac Surg 2019 Nov;120(5):456-461. Epub 2019 Jan 21 doi: 10.1016/j.jormas.2019.01.010. PMID: 30677564
Fine-needle aspiration cytology of salivary gland lesions: a systematic review.
Colella G, Cannavale R, Flamminio F, Foschini MP
J Oral Maxillofac Surg 2010 Sep;68(9):2146-53. Epub 2010 Jul 1 doi: 10.1016/j.joms.2009.09.064. PMID: 20580145
Surgical approaches to the submandibular gland: a review of literature.
Beahm DD, Peleaz L, Nuss DW, Schaitkin B, Sedlmayr JC, Rivera-Serrano CM, Zanation AM, Walvekar RR
Int J Surg 2009 Dec;7(6):503-9. Epub 2009 Sep 24 doi: 10.1016/j.ijsu.2009.09.006. PMID: 19782158

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...