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Leiomyosarcoma of Vessels

MedGen UID:
277864
•Concept ID:
C1336950
•
Neoplastic Process
Synonyms: Leiomyosarcoma of the Vessels; Vascular Leiomyosarcoma

Definition

An aggressive malignant smooth muscle neoplasm, arising from the walls of the vascular system. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Professional guidelines

PubMed

Treatment outlines for the management of primary leiomyosarcoma of the inferior vena cava.
Borghese O, Pisani A, Dubrez J, Di Centa I
J Med Vasc 2022 Apr;47(2):65-70. Epub 2022 May 20 doi: 10.1016/j.jdmv.2022.04.005. PMID: 35691665
Modern multimodality management of patients with caval leiomyosarcoma: New treatment paradigms and potential molecular insights.
Squires MH, Politano S, Pollock RE, Chen JL, Grignol V
J Surg Oncol 2021 Jun;123(7):1618-1623. Epub 2021 Mar 2 doi: 10.1002/jso.26442. PMID: 33650695
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment.
Llombart B, Serra-Guillén C, Requena C, Alsina M, Morgado-Carrasco D, Machado I, Sanmartín O
Actas Dermosifiliogr (Engl Ed) 2019 Jan-Feb;110(1):4-11. Epub 2018 Nov 5 doi: 10.1016/j.ad.2018.06.012. PMID: 30409380

Recent clinical studies

Etiology

Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death.
Bresler SC, Gosnell HL, Ko JS, Angeles CV, Ronen S, Billings SD, Patel RM
Am J Surg Pathol 2023 Dec 1;47(12):1417-1424. Epub 2023 Sep 19 doi: 10.1097/PAS.0000000000002126. PMID: 37727934
Not All Leiomyosarcomas Are the Same: How to Best Classify LMS.
Hickman A, Siontis BL
Curr Treat Options Oncol 2023 Apr;24(4):327-337. Epub 2023 Mar 8 doi: 10.1007/s11864-023-01067-2. PMID: 36884163
Primary malignancy of the inferior vena cava, a review of surgical treatments and outcomes.
Borghi A, Scotto DI Uccio A, Gronchi A
J Cardiovasc Surg (Torino) 2022 Dec;63(6):649-663. Epub 2022 Oct 14 doi: 10.23736/S0021-9509.22.12418-3. PMID: 36239928
A 10-year experience of leiomyosarcoma of the inferior vena cava.
Pan J, Qiu CY, He YY, Xue X, Li DL, Tian L, Cheng F, Wu ZH, Zhang HK
Phlebology 2022 Sep;37(8):572-578. Epub 2022 May 14 doi: 10.1177/02683555221101706. PMID: 35570826
Analysis of Extended Resection of Limb Soft Tissue Leiomyosarcoma.
Liu Q, Tang L, Hu X, Ye J, Liang P, Panayi AC, Wang S, Deng J
Biomed Res Int 2021;2021:2106972. Epub 2021 Aug 3 doi: 10.1155/2021/2106972. PMID: 34395610Free PMC Article

Diagnosis

A 10-year experience of leiomyosarcoma of the inferior vena cava.
Pan J, Qiu CY, He YY, Xue X, Li DL, Tian L, Cheng F, Wu ZH, Zhang HK
Phlebology 2022 Sep;37(8):572-578. Epub 2022 May 14 doi: 10.1177/02683555221101706. PMID: 35570826
Current update on IVC leiomyosarcoma.
Wang MX, Menias CO, Elsherif SB, Segaran N, Ganeshan D
Abdom Radiol (NY) 2021 Nov;46(11):5284-5296. Epub 2021 Aug 20 doi: 10.1007/s00261-021-03256-9. PMID: 34415408
Leiomyosarcoma of the inferior vena cava. Our experience and a review of the literature.
Rusu CB, Gorbatâi L, Szatmari L, Koren R, Bungărdean CI, Feciche BO, Bumbuluţ C, Andraş IM, Rahotă R, Telecan T, Coman I, Rath-Wolfson L, Crişan N
Rom J Morphol Embryol 2020;61(1):227-233. doi: 10.47162/RJME.61.1.25. PMID: 32747914Free PMC Article
Primary Leiomyosarcoma of the Pancreas: a Comprehensive Analytical Review.
Aleshawi AJ, Allouh MZ, Heis FH, Tashtush N, Heis HA
J Gastrointest Cancer 2020 Jun;51(2):433-438. doi: 10.1007/s12029-019-00282-1. PMID: 31392629
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment.
Llombart B, Serra-Guillén C, Requena C, Alsina M, Morgado-Carrasco D, Machado I, Sanmartín O
Actas Dermosifiliogr (Engl Ed) 2019 Jan-Feb;110(1):4-11. Epub 2018 Nov 5 doi: 10.1016/j.ad.2018.06.012. PMID: 30409380

Therapy

Surgical and reconstructive outcomes in primary venous leiomyosarcoma.
Sheaffer WW, Davila VJ, Mendes BC, Meltzer AJ, Stone WM, Soh IY, Truty MJ, Nagorney DM, Money SR, Bower TC
J Vasc Surg Venous Lymphat Disord 2022 Jul;10(4):901-907. Epub 2021 Aug 2 doi: 10.1016/j.jvsv.2021.07.010. PMID: 34352417
Modern multimodality management of patients with caval leiomyosarcoma: New treatment paradigms and potential molecular insights.
Squires MH, Politano S, Pollock RE, Chen JL, Grignol V
J Surg Oncol 2021 Jun;123(7):1618-1623. Epub 2021 Mar 2 doi: 10.1002/jso.26442. PMID: 33650695
Clinical Outcomes of Surgical Resection for Leiomyosarcoma of the Inferior Vena Cava.
Jeong S, Han Y, Cho YP, Kwon TW
Ann Vasc Surg 2019 Nov;61:377-383. Epub 2019 Aug 5 doi: 10.1016/j.avsg.2019.05.053. PMID: 31394210
Provisional matrix: A role for versican and hyaluronan.
Wight TN
Matrix Biol 2017 Jul;60-61:38-56. Epub 2016 Dec 6 doi: 10.1016/j.matbio.2016.12.001. PMID: 27932299Free PMC Article
Peripheral artery leiomyosarcoma.
Sakpal SV, Mehta R, Babel N, Chamberlain RS
J Vasc Surg 2009 Jan;49(1):217-21. doi: 10.1016/j.jvs.2008.07.018. PMID: 19174258

Prognosis

Not All Leiomyosarcomas Are the Same: How to Best Classify LMS.
Hickman A, Siontis BL
Curr Treat Options Oncol 2023 Apr;24(4):327-337. Epub 2023 Mar 8 doi: 10.1007/s11864-023-01067-2. PMID: 36884163
Current update on IVC leiomyosarcoma.
Wang MX, Menias CO, Elsherif SB, Segaran N, Ganeshan D
Abdom Radiol (NY) 2021 Nov;46(11):5284-5296. Epub 2021 Aug 20 doi: 10.1007/s00261-021-03256-9. PMID: 34415408
Leiomyosarcoma of the inferior vena cava. Our experience and a review of the literature.
Rusu CB, Gorbatâi L, Szatmari L, Koren R, Bungărdean CI, Feciche BO, Bumbuluţ C, Andraş IM, Rahotă R, Telecan T, Coman I, Rath-Wolfson L, Crişan N
Rom J Morphol Embryol 2020;61(1):227-233. doi: 10.47162/RJME.61.1.25. PMID: 32747914Free PMC Article
Inferior Vena Cava Leiomyosarcoma: What Method of Reconstruction for Which Type of Resection?
Gaignard E, Bergeat D, Robin F, Corbière L, Rayar M, Meunier B
World J Surg 2020 Oct;44(10):3537-3544. doi: 10.1007/s00268-020-05602-2. PMID: 32445073
Clinical characteristics and prognosis of primary leiomyosarcoma of the pancreas: a systematic review.
Xu J, Zhang T, Wang T, You L, Zhao Y
World J Surg Oncol 2013 Nov 12;11:290. doi: 10.1186/1477-7819-11-290. PMID: 24219646Free PMC Article

Clinical prediction guides

Not All Leiomyosarcomas Are the Same: How to Best Classify LMS.
Hickman A, Siontis BL
Curr Treat Options Oncol 2023 Apr;24(4):327-337. Epub 2023 Mar 8 doi: 10.1007/s11864-023-01067-2. PMID: 36884163
Femoral Vein Leiomyosarcoma Mimicking Thrombosis.
Pizzini AM, Tripolino C
Ann Vasc Surg 2021 Jul;74:520.e19-520.e22. Epub 2021 Feb 5 doi: 10.1016/j.avsg.2021.01.092. PMID: 33549770
Primary Leiomyosarcoma of the Pancreas: a Comprehensive Analytical Review.
Aleshawi AJ, Allouh MZ, Heis FH, Tashtush N, Heis HA
J Gastrointest Cancer 2020 Jun;51(2):433-438. doi: 10.1007/s12029-019-00282-1. PMID: 31392629
Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment.
Llombart B, Serra-Guillén C, Requena C, Alsina M, Morgado-Carrasco D, Machado I, Sanmartín O
Actas Dermosifiliogr (Engl Ed) 2019 Jan-Feb;110(1):4-11. Epub 2018 Nov 5 doi: 10.1016/j.ad.2018.06.012. PMID: 30409380
Clinical characteristics and prognosis of primary leiomyosarcoma of the pancreas: a systematic review.
Xu J, Zhang T, Wang T, You L, Zhao Y
World J Surg Oncol 2013 Nov 12;11:290. doi: 10.1186/1477-7819-11-290. PMID: 24219646Free PMC Article

Recent systematic reviews

Aggressive surgical approach with vascular resection and reconstruction for retroperitoneal sarcomas: a systematic review.
Hu H, Guo Q, Zhao J, Huang B, Du X
BMC Surg 2023 Sep 12;23(1):275. doi: 10.1186/s12893-023-02178-1. PMID: 37700246Free PMC Article
A systematic review of the current management approaches in leiomyosarcoma of inferior vena cava-Results from analysis of 118 cases.
Saikia J, Rastogi S, Barwad A, Dhamija E, Pandey R, Bhoriwal S, Deo S, Kumar S
Asian Cardiovasc Thorac Ann 2022 Mar;30(3):349-363. Epub 2021 Oct 21 doi: 10.1177/02184923211049911. PMID: 34672808
Contrast-Enhanced Ultrasound Imaging of Uterine Disorders: A Systematic Review.
Stoelinga B, Juffermans L, Dooper A, de Lange M, Hehenkamp W, Van den Bosch T, Huirne J
Ultrason Imaging 2021 Sep;43(5):239-252. Epub 2021 May 26 doi: 10.1177/01617346211017462. PMID: 34036872Free PMC Article
In-bag manual versus uncontained power morcellation for laparoscopic myomectomy.
Zullo F, Venturella R, Raffone A, Saccone G
Cochrane Database Syst Rev 2020 May 6;5(5):CD013352. doi: 10.1002/14651858.CD013352.pub2. PMID: 32374421Free PMC Article
Clinical characteristics and prognosis of primary leiomyosarcoma of the pancreas: a systematic review.
Xu J, Zhang T, Wang T, You L, Zhao Y
World J Surg Oncol 2013 Nov 12;11:290. doi: 10.1186/1477-7819-11-290. PMID: 24219646Free PMC Article

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