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Schizophrenia 2(SCZD2)

MedGen UID:
350323
•Concept ID:
C1864010
•
Disease or Syndrome
Synonyms: SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 11q-RELATED; SCZD2
 
Monarch Initiative: MONDO:0011307
OMIM®: 603342

Definition

A schizophrenia that has material basis in an autosomal dominant mutation of SCZD2 on chromosome 11q14-q21. [from MONDO]

Professional guidelines

PubMed

Diagnostic progression to schizophrenia in 35,255 patients with obsessive-compulsive disorder: a longitudinal follow-up study.
Chen MH, Tsai SJ, Liang CS, Cheng CM, Su TP, Chen TJ, Bai YM
Eur Arch Psychiatry Clin Neurosci 2023 Apr;273(3):541-551. Epub 2022 Mar 24 doi: 10.1007/s00406-021-01361-w. PMID: 35332401
Understanding healthcare burden and treatment patterns among young adults with schizophrenia.
Huang A, Amos TB, Joshi K, Wang L, Nash A
J Med Econ 2018 Oct;21(10):1026-1035. Epub 2018 Jul 27 doi: 10.1080/13696998.2018.1500370. PMID: 30001651
Social support and religion: mental health service use and treatment of schizophrenia.
Smolak A, Gearing RE, Alonzo D, Baldwin S, Harmon S, McHugh K
Community Ment Health J 2013 Aug;49(4):444-50. Epub 2012 Aug 2 doi: 10.1007/s10597-012-9536-8. PMID: 22855264Free PMC Article

Recent clinical studies

Etiology

Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Electroretinographic anomalies in schizophrenia.
Demmin DL, Davis Q, Roché M, Silverstein SM
J Abnorm Psychol 2018 May;127(4):417-428. doi: 10.1037/abn0000347. PMID: 29745706
Guidelines for the Pharmacotherapy of Schizophrenia in Adults.
Remington G, Addington D, Honer W, Ismail Z, Raedler T, Teehan M
Can J Psychiatry 2017 Sep;62(9):604-616. Epub 2017 Jul 13 doi: 10.1177/0706743717720448. PMID: 28703015Free PMC Article
Cannabis and schizophrenia.
McLoughlin BC, Pushpa-Rajah JA, Gillies D, Rathbone J, Variend H, Kalakouti E, Kyprianou K
Cochrane Database Syst Rev 2014 Oct 14;2014(10):CD004837. doi: 10.1002/14651858.CD004837.pub3. PMID: 25314586Free PMC Article
Prenatal inflammation and neurodevelopment in schizophrenia: a review of human studies.
Miller BJ, Culpepper N, Rapaport MH, Buckley P
Prog Neuropsychopharmacol Biol Psychiatry 2013 Apr 5;42:92-100. Epub 2012 Apr 1 doi: 10.1016/j.pnpbp.2012.03.010. PMID: 22510462

Diagnosis

Metabolomic Connections between Schizophrenia, Antipsychotic Drugs and Metabolic Syndrome: A Variety of Players.
Molina JD, Avila S, Rubio G, López-Muñoz F
Curr Pharm Des 2021;27(39):4049-4061. doi: 10.2174/1381612827666210804110139. PMID: 34348619
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Lithium for schizophrenia.
Leucht S, Kissling W, McGrath J
Cochrane Database Syst Rev 2007 Jul 18;(3):CD003834. doi: 10.1002/14651858.CD003834.pub2. PMID: 17636738
Lithium for schizophrenia.
Leucht S, McGrath J, Kissling W
Cochrane Database Syst Rev 2003;(3):CD003834. doi: 10.1002/14651858.CD003834. PMID: 12917990
Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia.
Fenton WS, Hibbeln J, Knable M
Biol Psychiatry 2000 Jan 1;47(1):8-21. doi: 10.1016/s0006-3223(99)00092-x. PMID: 10650444

Therapy

Associations between psoriasis and mental illness: an update for clinicians.
Hedemann TL, Liu X, Kang CN, Husain MI
Gen Hosp Psychiatry 2022 Mar-Apr;75:30-37. Epub 2022 Jan 25 doi: 10.1016/j.genhosppsych.2022.01.006. PMID: 35101785
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Guidelines for the Pharmacotherapy of Schizophrenia in Adults.
Remington G, Addington D, Honer W, Ismail Z, Raedler T, Teehan M
Can J Psychiatry 2017 Sep;62(9):604-616. Epub 2017 Jul 13 doi: 10.1177/0706743717720448. PMID: 28703015Free PMC Article
Cannabis and schizophrenia.
McLoughlin BC, Pushpa-Rajah JA, Gillies D, Rathbone J, Variend H, Kalakouti E, Kyprianou K
Cochrane Database Syst Rev 2014 Oct 14;2014(10):CD004837. doi: 10.1002/14651858.CD004837.pub3. PMID: 25314586Free PMC Article
Lithium for schizophrenia.
Leucht S, Kissling W, McGrath J
Cochrane Database Syst Rev 2007 Jul 18;(3):CD003834. doi: 10.1002/14651858.CD003834.pub2. PMID: 17636738

Prognosis

Unemployment, homelessness, and other societal outcomes in patients with schizophrenia: a real-world retrospective cohort study of the United States Veterans Health Administration database : Societal burden of schizophrenia among US veterans.
Lin D, Kim H, Wada K, Aboumrad M, Powell E, Zwain G, Benson C, Near AM
BMC Psychiatry 2022 Jul 8;22(1):458. doi: 10.1186/s12888-022-04022-x. PMID: 35804314Free PMC Article
The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia.
Na KS, Jung HY, Kim YK
Prog Neuropsychopharmacol Biol Psychiatry 2014 Jan 3;48:277-86. Epub 2012 Nov 1 doi: 10.1016/j.pnpbp.2012.10.022. PMID: 23123365
The dietary pattern of patients with schizophrenia: a systematic review.
Dipasquale S, Pariante CM, Dazzan P, Aguglia E, McGuire P, Mondelli V
J Psychiatr Res 2013 Feb;47(2):197-207. Epub 2012 Nov 12 doi: 10.1016/j.jpsychires.2012.10.005. PMID: 23153955
Treatment of the schizophrenia prodrome: is it presently ethical?
Cornblatt BA, Lencz T, Kane JM
Schizophr Res 2001 Aug 1;51(1):31-8. doi: 10.1016/s0920-9964(01)00236-5. PMID: 11479063
Medical disorders in the schizophrenic patient.
Vieweg V, Levenson J, Pandurangi A, Silverman J
Int J Psychiatry Med 1995;25(2):137-72. doi: 10.2190/TTYA-A89T-2YT9-UK2A. PMID: 7591491

Clinical prediction guides

Unemployment, homelessness, and other societal outcomes in patients with schizophrenia: a real-world retrospective cohort study of the United States Veterans Health Administration database : Societal burden of schizophrenia among US veterans.
Lin D, Kim H, Wada K, Aboumrad M, Powell E, Zwain G, Benson C, Near AM
BMC Psychiatry 2022 Jul 8;22(1):458. doi: 10.1186/s12888-022-04022-x. PMID: 35804314Free PMC Article
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Preliminary efficacy and tolerability profiles of first versus second-generation Long-Acting Injectable Antipsychotics in schizophrenia: A systematic review and meta-analysis.
Saucedo Uribe E, Carranza Navarro F, Guerrero Medrano AF, García Cervantes KI, Álvarez Villalobos NA, Acuña Rocha VD, Méndez Hernández M, Millán Alanís JM, Hinojosa Cavada CM, Zúñiga Hernández JA, Fernández Zambrano SM
J Psychiatr Res 2020 Oct;129:222-233. Epub 2020 Jul 30 doi: 10.1016/j.jpsychires.2020.06.013. PMID: 32805530
Electroretinographic anomalies in schizophrenia.
Demmin DL, Davis Q, Roché M, Silverstein SM
J Abnorm Psychol 2018 May;127(4):417-428. doi: 10.1037/abn0000347. PMID: 29745706
Cannabis and schizophrenia.
McLoughlin BC, Pushpa-Rajah JA, Gillies D, Rathbone J, Variend H, Kalakouti E, Kyprianou K
Cochrane Database Syst Rev 2014 Oct 14;2014(10):CD004837. doi: 10.1002/14651858.CD004837.pub3. PMID: 25314586Free PMC Article

Recent systematic reviews

Sex and Diffusion Tensor Imaging of White Matter in Schizophrenia: A Systematic Review Plus Meta-analysis of the Corpus Callosum.
Shahab S, Stefanik L, Foussias G, Lai MC, Anderson KK, Voineskos AN
Schizophr Bull 2018 Jan 13;44(1):203-221. doi: 10.1093/schbul/sbx049. PMID: 28449132Free PMC Article
Guidelines for the Pharmacotherapy of Schizophrenia in Adults.
Remington G, Addington D, Honer W, Ismail Z, Raedler T, Teehan M
Can J Psychiatry 2017 Sep;62(9):604-616. Epub 2017 Jul 13 doi: 10.1177/0706743717720448. PMID: 28703015Free PMC Article
Cannabis and schizophrenia.
McLoughlin BC, Pushpa-Rajah JA, Gillies D, Rathbone J, Variend H, Kalakouti E, Kyprianou K
Cochrane Database Syst Rev 2014 Oct 14;2014(10):CD004837. doi: 10.1002/14651858.CD004837.pub3. PMID: 25314586Free PMC Article
The dietary pattern of patients with schizophrenia: a systematic review.
Dipasquale S, Pariante CM, Dazzan P, Aguglia E, McGuire P, Mondelli V
J Psychiatr Res 2013 Feb;47(2):197-207. Epub 2012 Nov 12 doi: 10.1016/j.jpsychires.2012.10.005. PMID: 23153955
Lithium for schizophrenia.
Leucht S, Kissling W, McGrath J
Cochrane Database Syst Rev 2007 Jul 18;(3):CD003834. doi: 10.1002/14651858.CD003834.pub2. PMID: 17636738

Supplemental Content

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    Clinical resources

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