U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Schizophrenia 14(SCZD14)

MedGen UID:
436991
•Concept ID:
C2677614
•
Disease or Syndrome
Synonyms: SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 2q32-RELATED; SCZD14
 
Monarch Initiative: MONDO:0012879
OMIM®: 612361

Definition

A schizophrenia that has material basis in a mutation on chromosome 2q32.1. [from MONDO]

Professional guidelines

PubMed

Progressive brain structural changes after the first year of treatment in first-episode treatment-naive patients with deficit or nondeficit schizophrenia.
Lei W, Kirkpatrick B, Wang Q, Deng W, Li M, Guo W, Liang S, Li Y, Zhang C, Li X, Zhang P, Li Z, Xiang B, Chen J, Hu X, Zhang N, Li T
Psychiatry Res Neuroimaging 2019 Jun 30;288:12-20. Epub 2019 Apr 30 doi: 10.1016/j.pscychresns.2019.04.009. PMID: 31059954
Effectiveness and cost of atypical versus typical antipsychotic treatment for schizophrenia in routine care.
Stargardt T, Weinbrenner S, Busse R, Juckel G, Gericke CA
J Ment Health Policy Econ 2008 Jun;11(2):89-97. PMID: 18509216

Recent clinical studies

Etiology

Long-term safety and effectiveness of open-label lurasidone in antipsychotic-Naïve versus previously treated adolescents with Schizophrenia: A post-hoc analysis.
Correll CU, Tocco M, Pikalov A, Hsu J, Goldman R
Schizophr Res 2022 Feb;240:205-213. Epub 2022 Jan 12 doi: 10.1016/j.schres.2021.12.046. PMID: 35032906
Economic burden in Medicaid beneficiaries with recently relapsed schizophrenia or with uncontrolled symptoms of schizophrenia not adherent to antipsychotics.
Pilon D, Patel C, Lafeuille MH, Zhdanava M, Lin D, Côté-Sergent A, Rossi C, Lefebvre P, Joshi K
J Manag Care Spec Pharm 2021 Jul;27(7):904-914. doi: 10.18553/jmcp.2021.27.7.904. PMID: 34185557Free PMC Article
Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia.
Takahashi T, Goto T, Nobukawa S, Tanaka Y, Kikuchi M, Higashima M, Wada Y
Clin Neurophysiol 2018 Jan;129(1):222-231. Epub 2017 Nov 21 doi: 10.1016/j.clinph.2017.11.004. PMID: 29202390
Disturbances of Agency and Ownership in Schizophrenia: An Auditory Verbal Event Related Potentials Study.
Bühler T, Kindler J, Schneider RC, Strik W, Dierks T, Hubl D, Koenig T
Brain Topogr 2016 Sep;29(5):716-27. Epub 2016 May 21 doi: 10.1007/s10548-016-0495-1. PMID: 27209172
Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China.
Ran MS, Weng X, Chan CL, Chen EY, Tang CP, Lin FR, Mao WJ, Hu SH, Huang YQ, Xiang MZ
Br J Psychiatry 2015 Dec;207(6):495-500. Epub 2015 Sep 17 doi: 10.1192/bjp.bp.114.157685. PMID: 26382951Free PMC Article

Diagnosis

Hospital Inpatient Stays for Autistic Youth and Youth With Other Disabilities.
Rast JE, Roux AM, Fernandes SJ, D'Silva V, Shea LL
Pediatrics 2022 Apr 1;149(Suppl 4) doi: 10.1542/peds.2020-049437R. PMID: 35363287
Atypical Neuroleptic Malignant Syndrome: Case Reports and Diagnostic Challenges.
Szota AM, Radajewska I, Araszkiewicz AS
J Psychoactive Drugs 2022 Jul-Aug;54(3):284-293. Epub 2021 Aug 2 doi: 10.1080/02791072.2021.1957188. PMID: 34340640
Economic burden in Medicaid beneficiaries with recently relapsed schizophrenia or with uncontrolled symptoms of schizophrenia not adherent to antipsychotics.
Pilon D, Patel C, Lafeuille MH, Zhdanava M, Lin D, Côté-Sergent A, Rossi C, Lefebvre P, Joshi K
J Manag Care Spec Pharm 2021 Jul;27(7):904-914. doi: 10.18553/jmcp.2021.27.7.904. PMID: 34185557Free PMC Article
Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China.
Ran MS, Weng X, Chan CL, Chen EY, Tang CP, Lin FR, Mao WJ, Hu SH, Huang YQ, Xiang MZ
Br J Psychiatry 2015 Dec;207(6):495-500. Epub 2015 Sep 17 doi: 10.1192/bjp.bp.114.157685. PMID: 26382951Free PMC Article
Psychiatric diagnoses and suicide: revisiting the evidence.
Bertolote JM, Fleischmann A, De Leo D, Wasserman D
Crisis 2004;25(4):147-55. doi: 10.1027/0227-5910.25.4.147. PMID: 15580849

Therapy

Long-term safety and effectiveness of open-label lurasidone in antipsychotic-Naïve versus previously treated adolescents with Schizophrenia: A post-hoc analysis.
Correll CU, Tocco M, Pikalov A, Hsu J, Goldman R
Schizophr Res 2022 Feb;240:205-213. Epub 2022 Jan 12 doi: 10.1016/j.schres.2021.12.046. PMID: 35032906
Atypical Neuroleptic Malignant Syndrome: Case Reports and Diagnostic Challenges.
Szota AM, Radajewska I, Araszkiewicz AS
J Psychoactive Drugs 2022 Jul-Aug;54(3):284-293. Epub 2021 Aug 2 doi: 10.1080/02791072.2021.1957188. PMID: 34340640
Economic burden in Medicaid beneficiaries with recently relapsed schizophrenia or with uncontrolled symptoms of schizophrenia not adherent to antipsychotics.
Pilon D, Patel C, Lafeuille MH, Zhdanava M, Lin D, Côté-Sergent A, Rossi C, Lefebvre P, Joshi K
J Manag Care Spec Pharm 2021 Jul;27(7):904-914. doi: 10.18553/jmcp.2021.27.7.904. PMID: 34185557Free PMC Article
Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia.
Takahashi T, Goto T, Nobukawa S, Tanaka Y, Kikuchi M, Higashima M, Wada Y
Clin Neurophysiol 2018 Jan;129(1):222-231. Epub 2017 Nov 21 doi: 10.1016/j.clinph.2017.11.004. PMID: 29202390
Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China.
Ran MS, Weng X, Chan CL, Chen EY, Tang CP, Lin FR, Mao WJ, Hu SH, Huang YQ, Xiang MZ
Br J Psychiatry 2015 Dec;207(6):495-500. Epub 2015 Sep 17 doi: 10.1192/bjp.bp.114.157685. PMID: 26382951Free PMC Article

Prognosis

Comparing the Movement Assessment Battery for Children with the Bruininks-Oseretsky Test of Motor Proficiency in adolescents with and without schizophrenia.
Byrial P, Clausen L, Nyboe L
Physiother Res Int 2023 Apr;28(2):e1980. Epub 2022 Nov 9 doi: 10.1002/pri.1980. PMID: 36349933
Mortality trends in external causes of death in people with mental health disorders in Sweden, 1987-2010.
Hällgren J, Ösby U, Westman J, Gissler M
Scand J Public Health 2019 Mar;47(2):121-126. Epub 2018 Mar 1 doi: 10.1177/1403494818758912. PMID: 29493432
Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China.
Ran MS, Weng X, Chan CL, Chen EY, Tang CP, Lin FR, Mao WJ, Hu SH, Huang YQ, Xiang MZ
Br J Psychiatry 2015 Dec;207(6):495-500. Epub 2015 Sep 17 doi: 10.1192/bjp.bp.114.157685. PMID: 26382951Free PMC Article
Off-label use of sodium valproate for schizophrenia.
Horowitz E, Bergman LC, Ashkenazy C, Moscona-Hurvitz I, Grinvald-Fogel H, Magnezi R
PLoS One 2014;9(3):e92573. Epub 2014 Mar 24 doi: 10.1371/journal.pone.0092573. PMID: 24664210Free PMC Article
Spatial working memory and planning ability: contrasts between schizophrenia and bipolar I disorder.
Badcock JC, Michiel PT, Rock D
Cortex 2005 Dec;41(6):753-63. doi: 10.1016/s0010-9452(08)70294-6. PMID: 16350658

Clinical prediction guides

Long-term safety and effectiveness of open-label lurasidone in antipsychotic-Naïve versus previously treated adolescents with Schizophrenia: A post-hoc analysis.
Correll CU, Tocco M, Pikalov A, Hsu J, Goldman R
Schizophr Res 2022 Feb;240:205-213. Epub 2022 Jan 12 doi: 10.1016/j.schres.2021.12.046. PMID: 35032906
Economic burden in Medicaid beneficiaries with recently relapsed schizophrenia or with uncontrolled symptoms of schizophrenia not adherent to antipsychotics.
Pilon D, Patel C, Lafeuille MH, Zhdanava M, Lin D, Côté-Sergent A, Rossi C, Lefebvre P, Joshi K
J Manag Care Spec Pharm 2021 Jul;27(7):904-914. doi: 10.18553/jmcp.2021.27.7.904. PMID: 34185557Free PMC Article
Cortical stress regulation is disrupted in schizophrenia but not in clinical high risk for psychosis.
Schifani C, Tseng HH, Kenk M, Tagore A, Kiang M, Wilson AA, Houle S, Rusjan PM, Mizrahi R
Brain 2018 Jul 1;141(7):2213-2224. doi: 10.1093/brain/awy133. PMID: 29860329Free PMC Article
Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural China.
Ran MS, Weng X, Chan CL, Chen EY, Tang CP, Lin FR, Mao WJ, Hu SH, Huang YQ, Xiang MZ
Br J Psychiatry 2015 Dec;207(6):495-500. Epub 2015 Sep 17 doi: 10.1192/bjp.bp.114.157685. PMID: 26382951Free PMC Article
Off-label use of sodium valproate for schizophrenia.
Horowitz E, Bergman LC, Ashkenazy C, Moscona-Hurvitz I, Grinvald-Fogel H, Magnezi R
PLoS One 2014;9(3):e92573. Epub 2014 Mar 24 doi: 10.1371/journal.pone.0092573. PMID: 24664210Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...