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Schizophrenia 13(SCZD13)

MedGen UID:
416605
•Concept ID:
C2751663
•
Disease or Syndrome
Synonyms: SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 15q13-q14-RELATED; SCZD13
 
Monarch Initiative: MONDO:0013089
OMIM®: 613025

Definition

A schizophrenia that has material basis in a mutation on chromosome 15q13. [from MONDO]

Professional guidelines

PubMed

Health and use of health services of people who are homeless and at risk of homelessness who receive free primary health care in Dublin.
Keogh C, O'Brien KK, Hoban A, O'Carroll A, Fahey T
BMC Health Serv Res 2015 Feb 12;15:58. doi: 10.1186/s12913-015-0716-4. PMID: 25884629Free PMC Article
Preferences for schizophrenia treatment outcomes among public policy makers, consumers, families, and providers.
Shumway M, Saunders T, Shern D, Pines E, Downs A, Burbine T, Beller J
Psychiatr Serv 2003 Aug;54(8):1124-8. doi: 10.1176/appi.ps.54.8.1124. PMID: 12883140
A survey of sentenced prisoners transferred to hospital for urgent psychiatric treatment over a three-year period in one region.
Huckle PL
Med Sci Law 1997 Jan;37(1):37-40. doi: 10.1177/002580249703700110. PMID: 9029919

Recent clinical studies

Etiology

Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019.
Solmi M, Seitidis G, Mavridis D, Correll CU, Dragioti E, Guimond S, Tuominen L, Dargél A, Carvalho AF, Fornaro M, Maes M, Monaco F, Song M, Il Shin J, Cortese S
Mol Psychiatry 2023 Dec;28(12):5319-5327. Epub 2023 Jul 27 doi: 10.1038/s41380-023-02138-4. PMID: 37500825
Association Between Cardiovascular Risk Factors and Cognitive Impairment in People With Schizophrenia: A Systematic Review and Meta-analysis.
Hagi K, Nosaka T, Dickinson D, Lindenmayer JP, Lee J, Friedman J, Boyer L, Han M, Abdul-Rashid NA, Correll CU
JAMA Psychiatry 2021 May 1;78(5):510-518. doi: 10.1001/jamapsychiatry.2021.0015. PMID: 33656533Free PMC Article
Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016.
Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, McGrath JJ, Whiteford HA
Schizophr Bull 2018 Oct 17;44(6):1195-1203. doi: 10.1093/schbul/sby058. PMID: 29762765Free PMC Article
Relationship between toxoplasmosis and schizophrenia: A review.
Fuglewicz AJ, Piotrowski P, Stodolak A
Adv Clin Exp Med 2017 Sep;26(6):1031-1036. doi: 10.17219/acem/61435. PMID: 29068607
Early-onset schizophrenia.
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279

Diagnosis

Genetic Predisposition to Schizophrenia and Depressive Disorder Comorbidity.
Shnayder NA, Novitsky MA, Neznanov NG, Limankin OV, Asadullin AR, Petrov AV, Dmitrenko DV, Narodova EA, Popenko NV, Nasyrova RF
Genes (Basel) 2022 Mar 2;13(3) doi: 10.3390/genes13030457. PMID: 35328011Free PMC Article
Schizophrenia.
Borelli CM, Solari H
JAMA 2019 Oct 1;322(13):1322. doi: 10.1001/jama.2019.11073. PMID: 31573638
Schizophrenia and Physical Comorbidity.
Šimunović Filipčić I, Filipčić I
Psychiatr Danub 2018 Jun;30(Suppl 4):152-157. PMID: 29864751
Relationship between toxoplasmosis and schizophrenia: A review.
Fuglewicz AJ, Piotrowski P, Stodolak A
Adv Clin Exp Med 2017 Sep;26(6):1031-1036. doi: 10.17219/acem/61435. PMID: 29068607
Early-onset schizophrenia.
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279

Therapy

Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial.
Zhu MH, Liu ZJ, Hu QY, Yang JY, Jin Y, Zhu N, Huang Y, Shi DH, Liu MJ, Tan HY, Zhao L, Lv QY, Yi ZH, Wu FC, Li ZZ
Mil Med Res 2022 Oct 18;9(1):59. doi: 10.1186/s40779-022-00420-0. PMID: 36253804Free PMC Article
Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre-post studies.
Kishimoto T, Hagi K, Kurokawa S, Kane JM, Correll CU
Lancet Psychiatry 2021 May;8(5):387-404. Epub 2021 Apr 13 doi: 10.1016/S2215-0366(21)00039-0. PMID: 33862018
Association Between Cardiovascular Risk Factors and Cognitive Impairment in People With Schizophrenia: A Systematic Review and Meta-analysis.
Hagi K, Nosaka T, Dickinson D, Lindenmayer JP, Lee J, Friedman J, Boyer L, Han M, Abdul-Rashid NA, Correll CU
JAMA Psychiatry 2021 May 1;78(5):510-518. doi: 10.1001/jamapsychiatry.2021.0015. PMID: 33656533Free PMC Article
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.
Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD
Lancet Psychiatry 2020 Jan;7(1):64-77. Epub 2019 Dec 17 doi: 10.1016/S2215-0366(19)30416-X. PMID: 31860457Free PMC Article
Schizophrenia.
Borelli CM, Solari H
JAMA 2019 Oct 1;322(13):1322. doi: 10.1001/jama.2019.11073. PMID: 31573638

Prognosis

Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019.
Solmi M, Seitidis G, Mavridis D, Correll CU, Dragioti E, Guimond S, Tuominen L, Dargél A, Carvalho AF, Fornaro M, Maes M, Monaco F, Song M, Il Shin J, Cortese S
Mol Psychiatry 2023 Dec;28(12):5319-5327. Epub 2023 Jul 27 doi: 10.1038/s41380-023-02138-4. PMID: 37500825
Clinical Recovery and Long-Term Association of Specialized Early Intervention Services vs Treatment as Usual Among Individuals With First-Episode Schizophrenia Spectrum Disorder: 20-Year Follow-up of the OPUS Trial.
Hansen HG, Starzer M, Nilsson SF, Hjorthøj C, Albert N, Nordentoft M
JAMA Psychiatry 2023 Apr 1;80(4):371-379. doi: 10.1001/jamapsychiatry.2022.5164. PMID: 36811902Free PMC Article
Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis.
Hjorthøj C, Stürup AE, McGrath JJ, Nordentoft M
Lancet Psychiatry 2017 Apr;4(4):295-301. Epub 2017 Feb 22 doi: 10.1016/S2215-0366(17)30078-0. PMID: 28237639
Early-onset schizophrenia.
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279
Violence and schizophrenia.
Torrey EF
Schizophr Res 2006 Dec;88(1-3):3-4. Epub 2006 Nov 3 doi: 10.1016/j.schres.2006.09.010. PMID: 17084596

Clinical prediction guides

Genetic Predisposition to Schizophrenia and Depressive Disorder Comorbidity.
Shnayder NA, Novitsky MA, Neznanov NG, Limankin OV, Asadullin AR, Petrov AV, Dmitrenko DV, Narodova EA, Popenko NV, Nasyrova RF
Genes (Basel) 2022 Mar 2;13(3) doi: 10.3390/genes13030457. PMID: 35328011Free PMC Article
Gut permeability and its clinical relevance in schizophrenia.
Ishida I, Ogura J, Aizawa E, Ota M, Hidese S, Yomogida Y, Matsuo J, Yoshida S, Kunugi H
Neuropsychopharmacol Rep 2022 Mar;42(1):70-76. Epub 2022 Jan 25 doi: 10.1002/npr2.12227. PMID: 35080340Free PMC Article
Clinical and Sociodemographic Associates of Remission from Positive Symptoms in Schizophrenia.
Jana AK
East Asian Arch Psychiatry 2021 Mar;31(1):13-18. doi: 10.12809/eaap1961. PMID: 33753572
Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016.
Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, McGrath JJ, Whiteford HA
Schizophr Bull 2018 Oct 17;44(6):1195-1203. doi: 10.1093/schbul/sby058. PMID: 29762765Free PMC Article
The positive and negative syndrome scale (PANSS) for schizophrenia.
Kay SR, Fiszbein A, Opler LA
Schizophr Bull 1987;13(2):261-76. doi: 10.1093/schbul/13.2.261. PMID: 3616518

Recent systematic reviews

Cognitive behavioural therapy (group) for schizophrenia.
Guaiana G, Abbatecola M, Aali G, Tarantino F, Ebuenyi ID, Lucarini V, Li W, Zhang C, Pinto A
Cochrane Database Syst Rev 2022 Jul 12;7(7):CD009608. doi: 10.1002/14651858.CD009608.pub2. PMID: 35866377Free PMC Article
Schizophrenia.
Hasan A, Falkai P, Lehmann I, Gaebel W
Dtsch Arztebl Int 2020 Jun 12;117(24):412-419. doi: 10.3238/arztebl.2020.0412. PMID: 32865492Free PMC Article
Long-term outcomes of childhood sexual abuse: an umbrella review.
Hailes HP, Yu R, Danese A, Fazel S
Lancet Psychiatry 2019 Oct;6(10):830-839. Epub 2019 Sep 10 doi: 10.1016/S2215-0366(19)30286-X. PMID: 31519507Free PMC Article
Prevalence of co-occurring mental health diagnoses in the autism population: a systematic review and meta-analysis.
Lai MC, Kassee C, Besney R, Bonato S, Hull L, Mandy W, Szatmari P, Ameis SH
Lancet Psychiatry 2019 Oct;6(10):819-829. Epub 2019 Aug 22 doi: 10.1016/S2215-0366(19)30289-5. PMID: 31447415
Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.
Pacchiarotti I, Tiihonen J, Kotzalidis GD, Verdolini N, Murru A, Goikolea JM, Valentí M, Aedo A, Vieta E
Eur Neuropsychopharmacol 2019 Apr;29(4):457-470. Epub 2019 Feb 12 doi: 10.1016/j.euroneuro.2019.02.003. PMID: 30770235

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