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Gallbladder Neuroendocrine Carcinoma

MedGen UID:
474750
•Concept ID:
C3273117
•
Neoplastic Process
Synonyms: Gallbladder G3; Gallbladder High Grade Neuroendocrine Carcinoma; Gallbladder NEC; Gallbladder Poorly Differentiated Endocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Neuroendocrine Carcinoma

Professional guidelines

PubMed

Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article

Recent clinical studies

Etiology

Comparison of the clinical features and long-term prognosis of gallbladder neuroendocrine carcinoma versus gallbladder adenocarcinoma: A propensity score-matched analysis.
Hu YF, Ma WJ, Hu HJ, Gu HF, Jin YW, Li FY
Biomol Biomed 2023 Nov 3;23(6):1096-1107. doi: 10.17305/bb.2023.9582. PMID: 37724922Free PMC Article
Gallbladder neuroendocrine carcinoma: A single center experience.
Chu H, Zhang C, Shi Y, Wu W, Hu Z, Zhang J, Huang D
Medicine (Baltimore) 2020 Sep 4;99(36):e21912. doi: 10.1097/MD.0000000000021912. PMID: 32899024Free PMC Article
Gallbladder neuroendocrine carcinoma: report of 10 cases and comparision of clinicopathologic features with gallbladder adenocarcinoma.
Chen C, Wang L, Liu X, Zhang G, Zhao Y, Geng Z
Int J Clin Exp Pathol 2015;8(7):8218-26. Epub 2015 Jul 1 PMID: 26339390Free PMC Article

Diagnosis

Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
Brain metastasis from gallbladder neuroendocrine carcinoma.
Sasaki H, Goto T, Hirao M, Fujimoto Y
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-238114. PMID: 33257386Free PMC Article
Rare case of a gallbladder neuroendocrine carcinoma.
Fujii M, Saito H, Shiode J
Clin J Gastroenterol 2019 Feb;12(1):38-45. Epub 2018 Jul 12 doi: 10.1007/s12328-018-0883-z. PMID: 30003469
"Pure" large cell neuroendocrine carcinoma of the gallbladder. Report of a case and review of the literature.
Buscemi S, Orlando E, Damiano G, Portelli F, Palumbo VD, Valentino A, Marrazzo A, Buscemi G, Lo Monte AI
Int J Surg 2016 Apr;28 Suppl 1:S128-32. Epub 2015 Dec 18 doi: 10.1016/j.ijsu.2015.12.045. PMID: 26708705

Therapy

Brain metastasis from gallbladder neuroendocrine carcinoma.
Sasaki H, Goto T, Hirao M, Fujimoto Y
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-238114. PMID: 33257386Free PMC Article

Prognosis

Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
Brain metastasis from gallbladder neuroendocrine carcinoma.
Sasaki H, Goto T, Hirao M, Fujimoto Y
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-238114. PMID: 33257386Free PMC Article
Gallbladder neuroendocrine carcinoma: A single center experience.
Chu H, Zhang C, Shi Y, Wu W, Hu Z, Zhang J, Huang D
Medicine (Baltimore) 2020 Sep 4;99(36):e21912. doi: 10.1097/MD.0000000000021912. PMID: 32899024Free PMC Article
"Pure" large cell neuroendocrine carcinoma of the gallbladder. Report of a case and review of the literature.
Buscemi S, Orlando E, Damiano G, Portelli F, Palumbo VD, Valentino A, Marrazzo A, Buscemi G, Lo Monte AI
Int J Surg 2016 Apr;28 Suppl 1:S128-32. Epub 2015 Dec 18 doi: 10.1016/j.ijsu.2015.12.045. PMID: 26708705

Clinical prediction guides

Comparison of the clinical features and long-term prognosis of gallbladder neuroendocrine carcinoma versus gallbladder adenocarcinoma: A propensity score-matched analysis.
Hu YF, Ma WJ, Hu HJ, Gu HF, Jin YW, Li FY
Biomol Biomed 2023 Nov 3;23(6):1096-1107. doi: 10.17305/bb.2023.9582. PMID: 37724922Free PMC Article
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
Gallbladder neuroendocrine carcinoma: A single center experience.
Chu H, Zhang C, Shi Y, Wu W, Hu Z, Zhang J, Huang D
Medicine (Baltimore) 2020 Sep 4;99(36):e21912. doi: 10.1097/MD.0000000000021912. PMID: 32899024Free PMC Article
Whole-genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC).
Li M, Liu F, Zhang Y, Wu X, Wu W, Wang XA, Zhao S, Liu S, Liang H, Zhang F, Ma Q, Xiang S, Li H, Jiang L, Hu Y, Gong W, Zhang Y, Ma T, Zhang K, Liu Y, Liu Y
Cancer Lett 2017 Apr 10;391:20-27. Epub 2016 Dec 29 doi: 10.1016/j.canlet.2016.12.027. PMID: 28040546

Recent systematic reviews

Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article

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