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Breast carcinoma in situ

MedGen UID:
57817
•Concept ID:
C0154084
•
Neoplastic Process
Synonym: Breast Carcinoma In Situ
SNOMED CT: Carcinoma in situ of breast (189336000); Non-invasive carcinoma of breast (189336000)
 
Monarch Initiative: MONDO:0004658

Definition

A in situ carcinoma that involves the breast. [from MONDO]

Professional guidelines

PubMed

Can we improve breast cancer management using an image-guided histopathology workup supported by larger histopathology sections?
Tabár L, Dean PB, Lee Tucker F, Vörös A
Eur J Radiol 2023 Apr;161:110750. Epub 2023 Feb 18 doi: 10.1016/j.ejrad.2023.110750. PMID: 36821956
In situ breast carcinoma: diagnosis and treatment.
Hindle WH
Clin Obstet Gynecol 2002 Sep;45(3):774-7. doi: 10.1097/00003081-200209000-00025. PMID: 12370620
Management of in situ and minimally invasive breast carcinoma.
Frykberg ER, Bland KI
World J Surg 1994 Jan-Feb;18(1):45-57. doi: 10.1007/BF00348191. PMID: 8197776

Recent clinical studies

Etiology

The natural history of ductal carcinoma in situ (DCIS) in simulation models: A systematic review.
Poelhekken K, Lin Y, Greuter MJW, van der Vegt B, Dorrius M, de Bock GH
Breast 2023 Oct;71:74-81. Epub 2023 Jul 27 doi: 10.1016/j.breast.2023.07.012. PMID: 37541171Free PMC Article
Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Diagnosis

Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Overview of breast cancer.
Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Therapy

Comparing Breast Cancer and Cardiovascular Disease Risk and Use of Chemoprevention and Statins among Women with High-risk Breast Lesions.
Lawal KO, Nilan L, Amenta J, McGuinness JE, Kukafka R, Crew KD
Cancer Prev Res (Phila) 2023 Dec 1;16(12):661-667. doi: 10.1158/1940-6207.CAPR-23-0181. PMID: 37976537Free PMC Article
Impact of lobular carcinoma in situ on local recurrence in breast cancer treated with breast conservation therapy: a systematic review and meta-analysis.
Harris CG, Eslick GD
ANZ J Surg 2021 Sep;91(9):1696-1703. Epub 2021 Feb 26 doi: 10.1111/ans.16671. PMID: 33634956
Chemoprevention acceptance and adherence in women with high-risk breast lesions.
Roche CA, Tang R, Coopey SB, Hughes KS
Breast J 2019 Mar;25(2):190-195. Epub 2018 May 21 doi: 10.1111/tbj.13064. PMID: 29785770
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Overdiagnosis in breast imaging.
Evans A, Vinnicombe S
Breast 2017 Feb;31:270-273. Epub 2016 Oct 28 doi: 10.1016/j.breast.2016.10.011. PMID: 28029492

Prognosis

Absence of lobular carcinoma in situ is a poor prognostic marker in invasive lobular carcinoma.
Mouabbi JA, Raghavendra AS, Bassett RL Jr, Christgen M, Middleton L, Teshome M, Nasrazadani A, Hortobagyi G, Hassan A, Tripathy D, Layman RM
Eur J Cancer 2023 Sep;191:113250. Epub 2023 Jul 22 doi: 10.1016/j.ejca.2023.113250. PMID: 37573674Free PMC Article
Should low-risk DCIS lose the cancer label? An evidence review.
Ma T, Semsarian CR, Barratt A, Parker L, Pathmanathan N, Nickel B, Bell KJL
Breast Cancer Res Treat 2023 Jun;199(3):415-433. Epub 2023 Apr 19 doi: 10.1007/s10549-023-06934-y. PMID: 37074481Free PMC Article
Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Longitudinal study of breast cancer risk markers.
Zarwan C, Diamond O, Lam P, Ghebremichael MS, Lotz M, Shen AH, Sharifi S, Rozhansky F, Gore TA, Pories SE
Breast J 2021 Jan;27(1):48-51. Epub 2020 Oct 25 doi: 10.1111/tbj.14097. PMID: 33099843
Cancer statistics: Breast cancer in situ.
Ward EM, DeSantis CE, Lin CC, Kramer JL, Jemal A, Kohler B, Brawley OW, Gansler T
CA Cancer J Clin 2015 Nov-Dec;65(6):481-95. Epub 2015 Oct 2 doi: 10.3322/caac.21321. PMID: 26431342

Clinical prediction guides

Absence of lobular carcinoma in situ is a poor prognostic marker in invasive lobular carcinoma.
Mouabbi JA, Raghavendra AS, Bassett RL Jr, Christgen M, Middleton L, Teshome M, Nasrazadani A, Hortobagyi G, Hassan A, Tripathy D, Layman RM
Eur J Cancer 2023 Sep;191:113250. Epub 2023 Jul 22 doi: 10.1016/j.ejca.2023.113250. PMID: 37573674Free PMC Article
Management of Lobular Neoplasia Diagnosed by Core Biopsy.
Jani C, Lotz M, Keates S, Gupta Y, Walker A, Al Omari O, Parvez A, Patel D, Gnata M, Perry J, Khorashadi L, Weissmann L, Pories SE
Breast J 2023;2023:8185446. Epub 2023 Apr 18 doi: 10.1155/2023/8185446. PMID: 37114120Free PMC Article
Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Longitudinal study of breast cancer risk markers.
Zarwan C, Diamond O, Lam P, Ghebremichael MS, Lotz M, Shen AH, Sharifi S, Rozhansky F, Gore TA, Pories SE
Breast J 2021 Jan;27(1):48-51. Epub 2020 Oct 25 doi: 10.1111/tbj.14097. PMID: 33099843

Recent systematic reviews

The natural history of ductal carcinoma in situ (DCIS) in simulation models: A systematic review.
Poelhekken K, Lin Y, Greuter MJW, van der Vegt B, Dorrius M, de Bock GH
Breast 2023 Oct;71:74-81. Epub 2023 Jul 27 doi: 10.1016/j.breast.2023.07.012. PMID: 37541171Free PMC Article
Intercepting Premalignant, Preinvasive Breast Lesions Through Vaccination.
Zachariah NN, Basu A, Gautam N, Ramamoorthi G, Kodumudi KN, Kumar NB, Loftus L, Czerniecki BJ
Front Immunol 2021;12:786286. Epub 2021 Nov 24 doi: 10.3389/fimmu.2021.786286. PMID: 34899753Free PMC Article
Impact of lobular carcinoma in situ on local recurrence in breast cancer treated with breast conservation therapy: a systematic review and meta-analysis.
Harris CG, Eslick GD
ANZ J Surg 2021 Sep;91(9):1696-1703. Epub 2021 Feb 26 doi: 10.1111/ans.16671. PMID: 33634956

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