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Metastatic Ovarian Carcinoma

MedGen UID:
78864
•Concept ID:
C0278688
•
Neoplastic Process

Definition

A carcinoma that arises from the ovary and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Increased circulating tumor DNA as a noninvasive biomarker of early treatment response in patients with metastatic ovarian carcinoma: A pilot study.
Alves MC, Fonseca FLA, Yamada AMTD, Barros LADR, Lopes A, Silva LCFF, Luz AS, Melo Cruz FJS, Del Giglio A
Tumour Biol 2020 May;42(5):1010428320919198. doi: 10.1177/1010428320919198. PMID: 32364828
Recent advances with topotecan in the treatment of lung cancer.
O'Brien M, Eckardt J, Ramlau R
Oncologist 2007 Oct;12(10):1194-204. doi: 10.1634/theoncologist.12-10-1194. PMID: 17962613
The differential diagnosis of primary peritoneal papillary tumors.
Gitsch G, Tabery U, Feigl W, Breitenecker G
Arch Gynecol Obstet 1992;251(3):139-44. doi: 10.1007/BF02718376. PMID: 1376598

Recent clinical studies

Etiology

Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database.
Kajiyama H, Suzuki S, Utsumi F, Nishino K, Niimi K, Mizuno M, Yoshikawa N, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Shibata K, Nagasaka T, Kikkawa F
Nagoya J Med Sci 2019 May;81(2):193-198. doi: 10.18999/nagjms.81.2.193. PMID: 31239587Free PMC Article
Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma.
Kajiyama H, Suzuki S, Utsumi F, Yoshikawa N, Nishino K, Ikeda Y, Niimi K, Yamamoto E, Kawai M, Shibata K, Nagasaka T, Kikkawa F
Int J Clin Oncol 2019 Aug;24(8):950-956. Epub 2019 Apr 2 doi: 10.1007/s10147-019-01438-6. PMID: 30941534
Metastatic ovarian tumors: a clinicopathologic study of 150 cases.
Alvarado-Cabrero I, Rodríguez-Gómez A, Castelan-Pedraza J, Valencia-Cedillo R
Anal Quant Cytopathol Histpathol 2013 Oct;35(5):241-8. PMID: 24282903
Recent advances with topotecan in the treatment of lung cancer.
O'Brien M, Eckardt J, Ramlau R
Oncologist 2007 Oct;12(10):1194-204. doi: 10.1634/theoncologist.12-10-1194. PMID: 17962613
Adhesion molecules.
Skubitz AP
Cancer Treat Res 2002;107:305-29. doi: 10.1007/978-1-4757-3587-1_15. PMID: 11775459

Diagnosis

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma.
Sallinen H, Janhonen S, Pölönen P, Niskanen H, Liu OH, Kivelä A, Hartikainen JM, Anttila M, Heinäniemi M, Ylä-Herttuala S, Kaikkonen MU
BMC Cancer 2019 Nov 19;19(1):1121. doi: 10.1186/s12885-019-6339-0. PMID: 31744494Free PMC Article
Metastatic serous carcinoma presenting as inflammatory carcinoma over the breast-Report of two cases and literature review.
Panse G, Bossuyt V, Ko CJ
J Cutan Pathol 2018 Mar;45(3):234-239. Epub 2017 Dec 26 doi: 10.1111/cup.13091. PMID: 29194708
Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma.
Jiang RT, Yemelyanova A, Xing D, Anchoori RK, Hamazaki J, Murata S, Seidman JD, Wang TL, Roden RBS
J Ovarian Res 2017 Aug 7;10(1):53. doi: 10.1186/s13048-017-0347-y. PMID: 28784174Free PMC Article
New determinates of disease progression and outcome in metastatic ovarian carcinoma.
Davidson B, Reich R, Trope CG, Wang TL, Shih IeM
Histol Histopathol 2010 Dec;25(12):1591-609. doi: 10.14670/HH-25.1591. PMID: 20886439
A review of the cutaneous paraneoplastic associations and metastatic presentations of ovarian carcinoma.
Scheinfeld N
Clin Exp Dermatol 2008 Jan;33(1):10-5. Epub 2007 Nov 3 doi: 10.1111/j.1365-2230.2007.02560.x. PMID: 17983453

Therapy

Tunneling Nanotubular Expressways for Ultrafast and Accurate M1 Macrophage Delivery of Anticancer Drugs to Metastatic Ovarian Carcinoma.
Guo L, Zhang Y, Yang Z, Peng H, Wei R, Wang C, Feng M
ACS Nano 2019 Feb 26;13(2):1078-1096. Epub 2019 Jan 4 doi: 10.1021/acsnano.8b08872. PMID: 30608136
Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy.
Oren R, Addadi Y, Narunsky Haziza L, Dafni H, Rotkopf R, Meir G, Fishman A, Neeman M
Int J Cancer 2016 Oct 15;139(8):1788-98. Epub 2016 Jun 20 doi: 10.1002/ijc.30209. PMID: 27242346Free PMC Article
Three-dimensional collagen type I matrix up-regulates nuclear isoforms of the microtubule associated protein tau implicated in resistance to paclitaxel therapy in ovarian carcinoma.
Gurler H, Yu Y, Choi J, Kajdacsy-Balla AA, Barbolina MV
Int J Mol Sci 2015 Feb 4;16(2):3419-33. doi: 10.3390/ijms16023419. PMID: 25658796Free PMC Article
Recent advances with topotecan in the treatment of lung cancer.
O'Brien M, Eckardt J, Ramlau R
Oncologist 2007 Oct;12(10):1194-204. doi: 10.1634/theoncologist.12-10-1194. PMID: 17962613
Renal-ovarian axis: a case report and review.
Gavallos G, Tawfik O, Herrell D, Langenstroer P
Urology 2003 Oct;62(4):749. doi: 10.1016/s0090-4295(03)00585-5. PMID: 14550464

Prognosis

Integrated analysis of DNA methylome and transcriptome reveals SFRP1 and LIPG as potential drivers of ovarian cancer metastasis.
Yi J, Wu M, Zheng Z, Zhou Q, Li X, Lu Y, Liu P
J Gynecol Oncol 2023 Nov;34(6):e71. Epub 2023 Jun 27 doi: 10.3802/jgo.2023.34.e71. PMID: 37417299Free PMC Article
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma.
Sallinen H, Janhonen S, Pölönen P, Niskanen H, Liu OH, Kivelä A, Hartikainen JM, Anttila M, Heinäniemi M, Ylä-Herttuala S, Kaikkonen MU
BMC Cancer 2019 Nov 19;19(1):1121. doi: 10.1186/s12885-019-6339-0. PMID: 31744494Free PMC Article
A review of the cutaneous paraneoplastic associations and metastatic presentations of ovarian carcinoma.
Scheinfeld N
Clin Exp Dermatol 2008 Jan;33(1):10-5. Epub 2007 Nov 3 doi: 10.1111/j.1365-2230.2007.02560.x. PMID: 17983453
Palmar fasciitis and arthritis syndrome associated with metastatic ovarian carcinoma: a report of four cases.
Martorell EA, Murray PM, Peterson JJ, Menke DM, Calamia KT
J Hand Surg Am 2004 Jul;29(4):654-60. doi: 10.1016/j.jhsa.2004.04.012. PMID: 15249090
Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast.
Raptis S, Kanbour AI, Dusenbery D, Kanbour-Shakir A
Diagn Cytopathol 1996 Jul;15(1):1-6. doi: 10.1002/(SICI)1097-0339(199607)15:1<1::AID-DC2>3.0.CO;2-N. PMID: 8807244

Clinical prediction guides

Toll-like receptor 8 agonists improve NK-cell function primarily targeting CD56(bright)CD16(-) subset.
Veneziani I, Alicata C, Pelosi A, Landolina N, Ricci B, D'Oria V, Fagotti A, Scambia G, Moretta L, Maggi E
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003385. PMID: 35091452Free PMC Article
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma.
Sallinen H, Janhonen S, Pölönen P, Niskanen H, Liu OH, Kivelä A, Hartikainen JM, Anttila M, Heinäniemi M, Ylä-Herttuala S, Kaikkonen MU
BMC Cancer 2019 Nov 19;19(1):1121. doi: 10.1186/s12885-019-6339-0. PMID: 31744494Free PMC Article
Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma.
Kajiyama H, Suzuki S, Utsumi F, Yoshikawa N, Nishino K, Ikeda Y, Niimi K, Yamamoto E, Kawai M, Shibata K, Nagasaka T, Kikkawa F
Int J Clin Oncol 2019 Aug;24(8):950-956. Epub 2019 Apr 2 doi: 10.1007/s10147-019-01438-6. PMID: 30941534
New determinates of disease progression and outcome in metastatic ovarian carcinoma.
Davidson B, Reich R, Trope CG, Wang TL, Shih IeM
Histol Histopathol 2010 Dec;25(12):1591-609. doi: 10.14670/HH-25.1591. PMID: 20886439
NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma.
Dong HP, Elstrand MB, Holth A, Silins I, Berner A, Trope CG, Davidson B, Risberg B
Am J Clin Pathol 2006 Mar;125(3):451-8. PMID: 16613351

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