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Low Grade Salivary Gland Carcinoma

MedGen UID:
79029
•Concept ID:
C0279737
•
Neoplastic Process
Synonyms: Low-Grade Carcinoma of Salivary Gland; Low-Grade Carcinoma of the Salivary Gland

Definition

A salivary gland carcinoma with low grade histopathologic features. It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, and low grade salivary gland mucoepidermoid carcinoma. It usually follows a non-aggressive clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Salivary Gland Carcinoma

Professional guidelines

PubMed

Mucoepidermoid carcinoma of the parotid gland: Twenty-year experience in treatment and outcomes.
Chan SA, Van Abel KM, Lewis JE, Routman DM, Garcia JJ, Karp EE, Price DL, Janus JR, Kasperbauer JL, Moore EJ
Head Neck 2021 Sep;43(9):2663-2671. Epub 2021 May 1 doi: 10.1002/hed.26735. PMID: 33931913
Pulmonary mucoepidermoid carcinoma: diagnosis and treatment.
Kalhor N, Moran CA
Expert Rev Respir Med 2018 Mar;12(3):249-255. Epub 2018 Jan 17 doi: 10.1080/17476348.2018.1428563. PMID: 29338644
Angiogenesis in salivary gland tumors: from clinical significance to treatment.
Theocharis S, Gribilas G, Giaginis C, Patsouris E, Klijanienko J
Expert Opin Ther Targets 2015 Jun;19(6):807-19. Epub 2015 May 8 doi: 10.1517/14728222.2015.1016424. PMID: 25956454

Recent clinical studies

Etiology

Comprehensive Molecular Characterization of Polymorphous Adenocarcinoma, Cribriform Subtype: Identifying Novel Fusions and Fusion Partners.
Hahn E, Xu B, Katabi N, Dogan S, Smith SM, Perez-Ordonez B, Patel PB, MacMillan C, Lubin DJ, Gagan J, Weinreb I, Bishop JA
Mod Pathol 2023 Nov;36(11):100305. Epub 2023 Aug 17 doi: 10.1016/j.modpat.2023.100305. PMID: 37595638
Head and Neck Acinic Cell Carcinoma: A New Grading System Proposal and Diagnostic Utility of NR4A3 Immunohistochemistry.
Xu B, Saliba M, Ho A, Viswanathan K, Alzumaili B, Dogan S, Ghossein R, Katabi N
Am J Surg Pathol 2022 Jul 1;46(7):933-941. Epub 2022 Jan 17 doi: 10.1097/PAS.0000000000001867. PMID: 35034042Free PMC Article

Diagnosis

Using pan-TRK and RET Immunohistochemistry for the Detection of Fusion Types of Salivary Gland Secretory Carcinoma.
Su YJ, Lee YH, Jin YT, Hsieh MS
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):264-272. doi: 10.1097/PAI.0000000000001003. PMID: 35384876
Head and Neck Acinic Cell Carcinoma: A New Grading System Proposal and Diagnostic Utility of NR4A3 Immunohistochemistry.
Xu B, Saliba M, Ho A, Viswanathan K, Alzumaili B, Dogan S, Ghossein R, Katabi N
Am J Surg Pathol 2022 Jul 1;46(7):933-941. Epub 2022 Jan 17 doi: 10.1097/PAS.0000000000001867. PMID: 35034042Free PMC Article
Epithelial-Myoepithelial Carcinoma.
Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Pure intraductal carcinoma of the parotid gland: Cytologic findings on FNA sample. Report of one case.
Barizzi J, Merlo E, Schönegg R, Pelloni R, Mazzuchelli L, Fulciniti F
Diagn Cytopathol 2017 Nov;45(11):1046-1049. Epub 2017 Jun 23 doi: 10.1002/dc.23770. PMID: 28646544
Tigroid background in cytology of hyalinizing clear cell carcinoma of the salivary gland.
Yuan CT, Hsieh MS
Diagn Cytopathol 2016 Apr;44(4):338-41. Epub 2015 Dec 30 doi: 10.1002/dc.23423. PMID: 26715185

Prognosis

Head and Neck Acinic Cell Carcinoma: A New Grading System Proposal and Diagnostic Utility of NR4A3 Immunohistochemistry.
Xu B, Saliba M, Ho A, Viswanathan K, Alzumaili B, Dogan S, Ghossein R, Katabi N
Am J Surg Pathol 2022 Jul 1;46(7):933-941. Epub 2022 Jan 17 doi: 10.1097/PAS.0000000000001867. PMID: 35034042Free PMC Article
Epithelial-Myoepithelial Carcinoma.
Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226

Clinical prediction guides

Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases.
Bishop JA, Sajed DP, Weinreb I, Dickson BC, Bilodeau EA, Agaimy A, Franchi A, Khurram SA, Da Forno P, Robledo J, Kalmar JR, Aguirre S, Krane JF, Tapia JL, Kiss K, Cordell K, Rosebush M, Barrett AW, Oda D, Assaad A, Nagao T, Kawakami F, Nakaguro M, Zahir I, Wakeman K, Ihrler S, Chenevert J, Lin YL, Westra WH, Gagan J, Rooper LM
Head Neck Pathol 2021 Dec;15(4):1192-1201. Epub 2021 May 12 doi: 10.1007/s12105-021-01331-7. PMID: 33982215Free PMC Article
Tigroid background in cytology of hyalinizing clear cell carcinoma of the salivary gland.
Yuan CT, Hsieh MS
Diagn Cytopathol 2016 Apr;44(4):338-41. Epub 2015 Dec 30 doi: 10.1002/dc.23423. PMID: 26715185
Hyalinizing clear cell carcinoma with EWSR1-ATF1 fusion gene: report of three cases with molecular analyses.
Nakano T, Yamamoto H, Nishijima T, Tamiya S, Shiratsuchi H, Nakashima T, Komune S, Oda Y
Virchows Arch 2015 Jan;466(1):37-43. Epub 2014 Oct 31 doi: 10.1007/s00428-014-1676-5. PMID: 25359601

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