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Recurrent Anal Canal Carcinoma

MedGen UID:
82941
•Concept ID:
C0278556
•
Neoplastic Process
Synonyms: Recurrent Anal Canal Cancer; Recurrent Anal Cancer

Definition

The reemergence of anal carcinoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, Grem JL, Hecht JR, Hoffe S, Hubbard J, Hunt S, Hussan H, Jeck W, Johung KL, Joseph N, Kirilcuk N, Krishnamurthi S, Maratt J, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stotsky-Himelfarb E, Tavakkoli A, Willett CG, Williams G, Algieri F, Gurski L, Stehman K
J Natl Compr Canc Netw 2023 Jun;21(6):653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125
Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, Grem JL, Grothey A, Hochster HS, Hoffe S, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Mulcahy MF, Murphy JD, Nurkin S, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Wuthrick E, Gregory KM, Freedman-Cass DA
J Natl Compr Canc Netw 2018 Jul;16(7):852-871. doi: 10.6004/jnccn.2018.0060. PMID: 30006428Free PMC Article
Management of persistent anal canal carcinoma after combined-modality therapy: a clinical review.
Musio D, De Felice F, Raffetto N, Tombolini V
Radiat Oncol 2014 Jan 28;9:39. doi: 10.1186/1748-717X-9-39. PMID: 24472223Free PMC Article

Recent clinical studies

Etiology

RNA-seq analysis identifies transcriptomic profiles associated with anal cancer recurrence among people living with HIV.
Ye Y, Maroney KJ, Wiener HW, Mamaeva OA, Junkins AD, Burkholder GA, Sudenga SL, Khushman M, Al Diffalha S, Bansal A, Shrestha S
Ann Med 2023 Dec;55(1):2199366. doi: 10.1080/07853890.2023.2199366. PMID: 37177979Free PMC Article
Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Chemotherapy use in early stage anal canal squamous cell carcinoma and its impact on long-term overall survival(,,).
Huffman DL, Jayakrishnan TT, Vannatter BL, Monga DK, Finley GG, McCormick JT, Kirichenko AV, Wegner RE
Cancer Treat Res Commun 2021;27:100347. Epub 2021 Mar 5 doi: 10.1016/j.ctarc.2021.100347. PMID: 33711636
Definitive chemoradiotherapy for anal canal cancer: single-center experience.
Tachibana I, Nishimura Y, Inada M, Fukuda K, Ishikawa K, Nishikawa T, Yokokawa M, Nakamatsu K, Kanamori S, Hida JI
Int J Clin Oncol 2018 Dec;23(6):1121-1126. Epub 2018 Jul 10 doi: 10.1007/s10147-018-1316-1. PMID: 29992389
Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C
JAMA 2008 Apr 23;299(16):1914-21. doi: 10.1001/jama.299.16.1914. PMID: 18430910

Diagnosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Chemotherapy use in early stage anal canal squamous cell carcinoma and its impact on long-term overall survival(,,).
Huffman DL, Jayakrishnan TT, Vannatter BL, Monga DK, Finley GG, McCormick JT, Kirichenko AV, Wegner RE
Cancer Treat Res Commun 2021;27:100347. Epub 2021 Mar 5 doi: 10.1016/j.ctarc.2021.100347. PMID: 33711636
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990

Therapy

The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Nonplatinum-based therapy with Paclitaxel and Capecitabine for advanced squamous cell carcinomas of the anal canal: A population-based Danish anal cancer group study.
Truelsen CG, Serup-Hansen E, Storm KS, Havelund BM, Kronborg CS, Spindler KG
Cancer Med 2021 May;10(10):3224-3230. Epub 2021 May 7 doi: 10.1002/cam4.3886. PMID: 33960701Free PMC Article
Chemotherapy use in early stage anal canal squamous cell carcinoma and its impact on long-term overall survival(,,).
Huffman DL, Jayakrishnan TT, Vannatter BL, Monga DK, Finley GG, McCormick JT, Kirichenko AV, Wegner RE
Cancer Treat Res Commun 2021;27:100347. Epub 2021 Mar 5 doi: 10.1016/j.ctarc.2021.100347. PMID: 33711636
Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C
JAMA 2008 Apr 23;299(16):1914-21. doi: 10.1001/jama.299.16.1914. PMID: 18430910
Combination therapy for epidermoid carcinoma of the anal canal.
Beck DE, Karulf RE
Dis Colon Rectum 1994 Nov;37(11):1118-25. doi: 10.1007/BF02049814. PMID: 7956580

Prognosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Chemotherapy use in early stage anal canal squamous cell carcinoma and its impact on long-term overall survival(,,).
Huffman DL, Jayakrishnan TT, Vannatter BL, Monga DK, Finley GG, McCormick JT, Kirichenko AV, Wegner RE
Cancer Treat Res Commun 2021;27:100347. Epub 2021 Mar 5 doi: 10.1016/j.ctarc.2021.100347. PMID: 33711636
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990

Clinical prediction guides

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Management of inguinal lymph node metastases from rectal and anal canal adenocarcinoma.
Sato H, Maeda K, Kinugasa Y, Kagawa H, Tsukamoto S, Takahashi K, Nozawa H, Takii Y, Konishi T, Akagi Y, Suto T, Yamaguchi S, Ozawa H, Komori K, Ohue M, Hiro J, Shinji S, Minami K, Shimizu T, Sakamoto K, Uehara K, Takahashi H, Sugihara K
Colorectal Dis 2022 Oct;24(10):1150-1163. Epub 2022 May 26 doi: 10.1111/codi.16169. PMID: 35505622
Chemotherapy use in early stage anal canal squamous cell carcinoma and its impact on long-term overall survival(,,).
Huffman DL, Jayakrishnan TT, Vannatter BL, Monga DK, Finley GG, McCormick JT, Kirichenko AV, Wegner RE
Cancer Treat Res Commun 2021;27:100347. Epub 2021 Mar 5 doi: 10.1016/j.ctarc.2021.100347. PMID: 33711636
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990

Recent systematic reviews

Assessing Circulating Tumour DNA (ctDNA) as a Biomarker for Anal Cancer Management: A Systematic Review.
Temperley HC, Fannon T, O'Sullivan NJ, O'Neill M, Mac Curtain BM, Gilham C, O'Sullivan J, O'Kane G, Mehigan BJ, O'Toole S, Larkin JO, Gallagher D, McCormick P, Kelly ME
Int J Mol Sci 2024 Apr 3;25(7) doi: 10.3390/ijms25074005. PMID: 38612815Free PMC Article
Management of persistent anal canal carcinoma after combined-modality therapy: a clinical review.
Musio D, De Felice F, Raffetto N, Tombolini V
Radiat Oncol 2014 Jan 28;9:39. doi: 10.1186/1748-717X-9-39. PMID: 24472223Free PMC Article
Sentinel node mapping in anal canal cancer: systematic review and meta-analysis.
Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M
J Gastrointestin Liver Dis 2013 Sep;22(3):321-8. PMID: 24078990

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