U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult germ cell tumor

MedGen UID:
859695
•Concept ID:
C3900101
•
Neoplastic Process
Synonyms: Adult Germ Cell Tumor; adult germ cell tumor; Adult germ cell tumour; germ cell tumor of adults; germ cell tumour of adults
 
Monarch Initiative: MONDO:0044878

Definition

A germ cell tumor that occurs during adulthood. [from NCI]

Professional guidelines

PubMed

Clinical practice guidelines for the management of adult diffuse gliomas.
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616
Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797

Recent clinical studies

Etiology

Intracranial Germ Cell Tumors.
Yeoh TDYY, Nga V, Kimpo M, Lo SS, Vellayappan B
Semin Neurol 2023 Dec;43(6):897-908. Epub 2023 Nov 14 doi: 10.1055/s-0043-1776763. PMID: 37963583
Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Testicular germ cell tumors: Genomic alternations and RAS-dependent signaling.
Nakhaei-Rad S, Soleimani Z, Vahedi S, Gorjinia Z
Crit Rev Oncol Hematol 2023 Mar;183:103928. Epub 2023 Jan 27 doi: 10.1016/j.critrevonc.2023.103928. PMID: 36717007
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Treatment of germ cell testicular cancer.
Koši Kunac A, Gnjidić M, Antunac Golubić Z, Gamulin M
Acta Clin Croat 2020 Sep;59(3):496-504. doi: 10.20471/acc.2020.59.03.14. PMID: 34177060Free PMC Article

Diagnosis

Intracranial Germ Cell Tumors.
Yeoh TDYY, Nga V, Kimpo M, Lo SS, Vellayappan B
Semin Neurol 2023 Dec;43(6):897-908. Epub 2023 Nov 14 doi: 10.1055/s-0043-1776763. PMID: 37963583
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Treatment of germ cell testicular cancer.
Koši Kunac A, Gnjidić M, Antunac Golubić Z, Gamulin M
Acta Clin Croat 2020 Sep;59(3):496-504. doi: 10.20471/acc.2020.59.03.14. PMID: 34177060Free PMC Article
Spermatocytic seminoma.
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276

Therapy

Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Current Management of Refractory Germ Cell Tumors.
Abughanimeh O, Teply BA
Curr Oncol Rep 2021 Jul 16;23(9):101. doi: 10.1007/s11912-021-01093-z. PMID: 34269906
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276
Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors.
Kondagunta GV, Bacik J, Donadio A, Bajorin D, Marion S, Sheinfeld J, Bosl GJ, Motzer RJ
J Clin Oncol 2005 Sep 20;23(27):6549-55. doi: 10.1200/JCO.2005.19.638. PMID: 16170162

Prognosis

Germ Cell Tumors in Adolescents and Young Adults.
Calaminus G, Joffe J
Prog Tumor Res 2016;43:115-27. Epub 2016 Sep 5 doi: 10.1159/000447081. PMID: 27595361
Male Extragonadal Germ Cell Tumors of the Adult.
Busch J, Seidel C, Zengerling F
Oncol Res Treat 2016;39(3):140-4. Epub 2016 Feb 23 doi: 10.1159/000444271. PMID: 27032104
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276
Intracranial germ cell tumors.
Packer RJ, Cohen BH, Cooney K
Oncologist 2000;5(4):312-20. PMID: 10964999
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088

Clinical prediction guides

Updates in 2022 on the staging of testicular germ cell tumors.
Canete Portillo S, Rais-Bahrami S, Magi-Galluzzi C
Hum Pathol 2022 Oct;128:152-160. Epub 2022 Aug 1 doi: 10.1016/j.humpath.2022.07.009. PMID: 35926809
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence.
Lakpour N, Saliminejad K, Ghods R, Reza Sadeghi M, Pilatz A, Khosravi F, Madjd Z
Andrologia 2021 May;53(4):e13998. Epub 2021 Feb 3 doi: 10.1111/and.13998. PMID: 33534171
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650

Recent systematic reviews

Neoadjuvant treatment for stage III and IV cutaneous melanoma.
Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Characteristics and Outcomes in Pediatric Versus Adult Craniopharyngiomas: A Systematic Review and Meta-Analysis.
Pang JC, Chung DD, Wang J, Abiri A, Lien BV, Himstead AS, Ovakimyan A, Kim MG, Hsu FPK, Kuan EC
Neurosurgery 2023 Jun 1;92(6):1112-1129. Epub 2023 Jan 13 doi: 10.1227/neu.0000000000002346. PMID: 36639856
Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Use of sunscreen and risk of melanoma and non-melanoma skin cancer: a systematic review and meta-analysis.
Silva ESD, Tavares R, Paulitsch FDS, Zhang L
Eur J Dermatol 2018 Apr 1;28(2):186-201. doi: 10.1684/ejd.2018.3251. PMID: 29620003

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...