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Moderate epithelial dysplasia

MedGen UID:
87193
•Concept ID:
C0334059
•
Cell or Molecular Dysfunction
Synonyms: Grade 2 Intraepithelial Neoplasia; Grade II Intraepithelial Neoplasia; Moderate Epithelial Dysplasia
SNOMED CT: Moderate epithelial dysplasia (55638007)

Professional guidelines

PubMed

Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery.
Labadie JG, Ibrahim SA, Worley B, Kang BY, Rakita U, Rigali S, Arndt KA, Bernstein E, Brauer JA, Chandra S, Didwania A, DiGiorgio C, Donelan M, Dover JS, Galadari H, Geronemus RG, Goldman MP, Haedersdal M, Hruza G, Ibrahimi OA, Kauvar A, Kelly KM, Krakowski AC, Miest R, Orringer JS, Ozog DM, Ross EV, Shumaker PR, Sobanko JF, Suozzi K, Taylor MB, Teng JMC, Uebelhoer NS, Waibel J, Wanner M, Ratchev I, Christensen RE, Poon E, Miller CH, Alam M
JAMA Dermatol 2022 Oct 1;158(10):1193-1201. doi: 10.1001/jamadermatol.2022.3234. PMID: 35976634
The clinical utility of contemporary oral epithelial dysplasia grading systems.
Sathasivam HP, Sloan P, Thomson PJ, Robinson M
J Oral Pathol Med 2022 Feb;51(2):180-187. Epub 2021 Dec 15 doi: 10.1111/jop.13262. PMID: 34797585
Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019.
Pimentel-Nunes P, Libânio D, Marcos-Pinto R, Areia M, Leja M, Esposito G, Garrido M, Kikuste I, Megraud F, Matysiak-Budnik T, Annibale B, Dumonceau JM, Barros R, Fléjou JF, Carneiro F, van Hooft JE, Kuipers EJ, Dinis-Ribeiro M
Endoscopy 2019 Apr;51(4):365-388. Epub 2019 Mar 6 doi: 10.1055/a-0859-1883. PMID: 30841008

Recent clinical studies

Etiology

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Gastroesophageal reflux is associated with an increased risk of gastric cardiac polyps: a case-control study of 140 cases.
Zeng SX, Liang YP, Wu XY, Tan SW, Liang Q, Wen ZF, Tao J
Ann Palliat Med 2021 Jul;10(7):7173-7183. Epub 2021 Jun 21 doi: 10.21037/apm-21-260. PMID: 34154359
MORPHOLOGICAL CHANGES IN PERIODONTAL TISSUE DURING PERIODONTITIS.
Kvaratskhelia S, Nemsadze T, Puturidze S, Gogiberidze M, Jorbenadze T
Georgian Med News 2021 Feb;(311):50-54. PMID: 33814390
p53 expression and mutation analysis of odontogenic cysts with and without dysplasia.
Cox DP
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 Jan;113(1):90-8. Epub 2012 Feb 3 doi: 10.1016/j.tripleo.2011.07.027. PMID: 22669068
Expression of p63 protein and mRNA in oral epithelial dysplasia.
Chen YK, Hsue SS, Lin LM
J Oral Pathol Med 2005 Apr;34(4):232-9. doi: 10.1111/j.1600-0714.2004.00277.x. PMID: 15752259

Diagnosis

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Gastroesophageal reflux is associated with an increased risk of gastric cardiac polyps: a case-control study of 140 cases.
Zeng SX, Liang YP, Wu XY, Tan SW, Liang Q, Wen ZF, Tao J
Ann Palliat Med 2021 Jul;10(7):7173-7183. Epub 2021 Jun 21 doi: 10.21037/apm-21-260. PMID: 34154359
MORPHOLOGICAL CHANGES IN PERIODONTAL TISSUE DURING PERIODONTITIS.
Kvaratskhelia S, Nemsadze T, Puturidze S, Gogiberidze M, Jorbenadze T
Georgian Med News 2021 Feb;(311):50-54. PMID: 33814390
Adenoid dysplasia of the oral mucosa.
Bunn B, Hunter K, Khurram SA, van Heerden WF
Oral Surg Oral Med Oral Pathol Oral Radiol 2014 Nov;118(5):586-92. Epub 2014 Aug 15 doi: 10.1016/j.oooo.2014.08.009. PMID: 25442496
AgNOR cut-point to distinguish mild and moderate epithelial dysplasia.
Chattopadhyay A, Ray JG
J Oral Pathol Med 2008 Feb;37(2):78-82. doi: 10.1111/j.1600-0714.2007.00585.x. PMID: 18197851

Therapy

Gastroesophageal reflux is associated with an increased risk of gastric cardiac polyps: a case-control study of 140 cases.
Zeng SX, Liang YP, Wu XY, Tan SW, Liang Q, Wen ZF, Tao J
Ann Palliat Med 2021 Jul;10(7):7173-7183. Epub 2021 Jun 21 doi: 10.21037/apm-21-260. PMID: 34154359
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis.
Lima Gda S, Silva GF, Gomes AP, de Araújo LM, Salum FG
J Appl Oral Sci 2010 Sep-Oct;18(5):533-7. doi: 10.1590/s1678-77572010000500018. PMID: 21085813Free PMC Article

Prognosis

Gastroesophageal reflux is associated with an increased risk of gastric cardiac polyps: a case-control study of 140 cases.
Zeng SX, Liang YP, Wu XY, Tan SW, Liang Q, Wen ZF, Tao J
Ann Palliat Med 2021 Jul;10(7):7173-7183. Epub 2021 Jun 21 doi: 10.21037/apm-21-260. PMID: 34154359
Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis.
Lima Gda S, Silva GF, Gomes AP, de Araújo LM, Salum FG
J Appl Oral Sci 2010 Sep-Oct;18(5):533-7. doi: 10.1590/s1678-77572010000500018. PMID: 21085813Free PMC Article
Expression of p63 protein and mRNA in oral epithelial dysplasia.
Chen YK, Hsue SS, Lin LM
J Oral Pathol Med 2005 Apr;34(4):232-9. doi: 10.1111/j.1600-0714.2004.00277.x. PMID: 15752259
The clinical relevance of epithelial dysplasia in the surgical margins of tongue and floor of mouth squamous cell carcinoma: an analysis of 37 patients.
Weijers M, Snow GB, Bezemer PD, van der Wal JE, van der Waal I
J Oral Pathol Med 2002 Jan;31(1):11-5. doi: 10.1034/j.1600-0714.2002.310103.x. PMID: 11896817
Analysis of the tissue marker AgNOR in leukoplaquia and oral squamous cell carcinoma.
Cano Montoya LC, Alvarez Gómez GJ, Valencia Londoño WA, Ramírez España JA, Prada Navas CA
Med Oral 2002 Jan-Feb;7(1):17-21, 22-5. PMID: 11788805

Clinical prediction guides

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment.
Mori K, Haraguchi S, Hiori M, Shimada J, Ohmori Y
BMC Cancer 2015 Aug 5;15:573. doi: 10.1186/s12885-015-1587-0. PMID: 26242181Free PMC Article
Adenoid dysplasia of the oral mucosa.
Bunn B, Hunter K, Khurram SA, van Heerden WF
Oral Surg Oral Med Oral Pathol Oral Radiol 2014 Nov;118(5):586-92. Epub 2014 Aug 15 doi: 10.1016/j.oooo.2014.08.009. PMID: 25442496
Expression of p63 protein and mRNA in oral epithelial dysplasia.
Chen YK, Hsue SS, Lin LM
J Oral Pathol Med 2005 Apr;34(4):232-9. doi: 10.1111/j.1600-0714.2004.00277.x. PMID: 15752259
The clinical relevance of epithelial dysplasia in the surgical margins of tongue and floor of mouth squamous cell carcinoma: an analysis of 37 patients.
Weijers M, Snow GB, Bezemer PD, van der Wal JE, van der Waal I
J Oral Pathol Med 2002 Jan;31(1):11-5. doi: 10.1034/j.1600-0714.2002.310103.x. PMID: 11896817

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