Ppp3cb protein phosphatase 3 catalytic subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp3cbprovided by RGD
Official Full Name: protein phosphatase 3 catalytic subunit betaprovided by RGD
Primary source: RGD:3383
See related: Ensembl:ENSRNOG00000054782 AllianceGenome:RGD:3383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Calna2
Summary: Enables calcium-dependent protein serine/threonine phosphatase activity and calmodulin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to amphetamine. Located in plasma membrane. Part of protein-containing complex. Is active in synapse. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 499.2), Muscle (RPKM 383.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (3809182..3854204)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (3759950..3804976)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (4209702..4236895)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcineurin suppresses rat H9c2 cardiomyocyteprotective autophagy under chronic intermittent hypoxia by downregulating the AMPK pathway.
Title: Calcineurin suppresses rat H9c2 cardiomyocyteprotective autophagy under chronic intermittent hypoxia by downregulating the AMPK pathway.
Aerobic training did not cause any changes (p < 0.05) in CaN A or CaN B expression levels in either the soleus or the plantaris muscle.
Title: NFAT isoforms regulate muscle fiber type transition without altering CaN during aerobic training.
A binding site for calcineurin A beta was found to reside within splice cassette II of NBCn1.
Title: Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions.
The expression levels of both the catalytic A and regulatory B subunits of calcineurin were increased at 1 and 2 weeks, but not at 9 weeks, after the induction of streptozotocin diabetes.
Title: Calcineurin and Akt expression in hypertrophied bladder in STZ-induced diabetic rat.
A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes.
Title: Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.
Mechanical stretch and alpha-1-adrenergic stimulation contribute to a decrease of cardiomyocyte NGF expression via the calcineurin-NFAT pathway.
Title: Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway.
A beta and PrP increased CaN activity, inducing BAD dephosphorylation and translocation to mitochondria and, subsequently, cytochrome c release, causing apoptosis. Drugs targeting CaN might be valuable for these neurodegenerative disorders.
Title: Overactivation of calcineurin induced by amyloid-beta and prion proteins.
Calcineurin A beta is significantly decreased in the particulate fractions but is not changed in the soluble fractions of the striatum of methamphetamine-sensitized rats.
Title: Decreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine.
calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate
Title: The protein phosphatase calcineurin determines basal parathyroid hormone gene expression.
The isolation and transport of calcineurin Aalpha and calcineurin Abeta in rat aortic smooth muscle cells are reported.
Title: Nuclear translocation of calcineurin Abeta but not calcineurin Aalpha by platelet-derived growth factor in rat aortic smooth muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143458 (e-PCR)
- UniSTS:232705

RH131331 (e-PCR)
- UniSTS:214614

AU022835 (e-PCR)
- UniSTS:209001

RH140251 (e-PCR)
- UniSTS:222330

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcineurin-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcineurin-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-ion regulated exocytosis	IEA Inferred from Electronic Annotation more info
involved_in calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in calcium-ion regulated exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in lymphangiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymphangiogenesis	ISO Inferred from Sequence Orthology more info
involved_in muscle cell cellular homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in T-tubule	IEA Inferred from Electronic Annotation more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	ISO Inferred from Sequence Orthology more info
part_of calcineurin complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Names: CAM-PRP catalytic subunit; CNA beta; CaN Abeta; Calcineurin subunit A beta; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase-2Bb

NP_058738.1

EC 3.1.3.16

XP_038948913.1

EC 3.1.3.16

XP_038948914.1

EC 3.1.3.16

XP_038948915.1

EC 3.1.3.16

XP_038948916.1

EC 3.1.3.16

XP_038948917.1

EC 3.1.3.16

XP_038948918.1

EC 3.1.3.16

XP_038948919.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017042.2 → NP_058738.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

See identical proteins and their annotated locations for NP_058738.1

Status: PROVISIONAL

Source sequence(s)

D90036

UniProtKB/Swiss-Prot

P20651, Q6LDJ7

UniProtKB/TrEMBL

A0A8I6A2X6

Related

ENSRNOP00000074339.2, ENSRNOT00000082236.2

Conserved Domains (2) summary

smart00156
Location:67 → 338

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

3809182..3854204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092985.1 → XP_038948913.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

UniProtKB/TrEMBL

A0A8I6A2X6, A0A8I6AAD3

Related

ENSRNOP00000090582.1, ENSRNOT00000101580.1

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_039092989.1 → XP_038948917.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

UniProtKB/TrEMBL

A0A8I6A2X6

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_039092986.1 → XP_038948914.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

UniProtKB/TrEMBL

A0A8I6A2X6

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_039092990.1 → XP_038948918.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6

UniProtKB/TrEMBL

A0A8I6A2X6, A0A8I6GLZ4

Related

ENSRNOP00000096220.1, ENSRNOT00000107965.1

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_039092988.1 → XP_038948916.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

UniProtKB/TrEMBL

A0A8I6A2X6

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_039092991.1 → XP_038948919.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7

UniProtKB/TrEMBL

A0A8I6A2X6

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_039092987.1 → XP_038948915.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

UniProtKB/TrEMBL

A0A8I6A2X6

Conserved Domains (1) summary

cd07416
Location:50 → 352

MPP_PP2B; PP2B, metallophosphatase domain