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Solitary fibrous tumor

MedGen UID:
224764
•Concept ID:
C1266119
•
Neoplastic Process
Synonyms: Fibrous Tumor, Solitary; Fibrous Tumors, Solitary; Solitary Fibrous Tumor; Solitary Fibrous Tumors; Tumor, Solitary Fibrous; Tumors, Solitary Fibrous
SNOMED CT: Localized fibrous tumor (128736003); Solitary fibrous tumor (128736003); Hemangiopericytoma (128736003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016238
Orphanet: ORPHA2126

Definition

A rare spindle cell neoplasm that may be benign or malignant and that most frequently arises from the pleura and peritoneum and rarely from other sites such as head and neck, liver and skeletal muscle. SFT may be clinically asymptomatic or may present with enlarging mass, compressive effects depending on the site involved and rarely with paraneoplastic manifestations (osteoarthropathy or hypoglycemia). [from ORDO]

Professional guidelines

PubMed

Toward Better Understanding and Management of Solitary Fibrous Tumor.
Kazazian K, Demicco EG, de Perrot M, Strauss D, Swallow CJ
Surg Oncol Clin N Am 2022 Jul;31(3):459-483. doi: 10.1016/j.soc.2022.03.009. PMID: 35715145
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866

Recent clinical studies

Etiology

Skull base hemangiopericytomas.
Tobias S, Jahshan S, Grober Y, Soustiel JF
Acta Neurol Belg 2022 Dec;122(6):1537-1545. Epub 2021 Sep 30 doi: 10.1007/s13760-021-01812-0. PMID: 34595730
STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866
Solitary fibrous tumor.
Yilmaz C, Kabatas S, Ozen OI, Gulsen S, Caner H, Altinors N
J Clin Neurosci 2009 Dec;16(12):1578-81. Epub 2009 Sep 29 doi: 10.1016/j.jocn.2009.02.039. PMID: 19793658

Diagnosis

Toward Better Understanding and Management of Solitary Fibrous Tumor.
Kazazian K, Demicco EG, de Perrot M, Strauss D, Swallow CJ
Surg Oncol Clin N Am 2022 Jul;31(3):459-483. doi: 10.1016/j.soc.2022.03.009. PMID: 35715145
Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up.
Shmuly T, Ben Zvi Y, Chaushu G, Kaplan I
Medicina (Kaunas) 2021 Feb 8;57(2) doi: 10.3390/medicina57020152. PMID: 33567630Free PMC Article
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Dedifferentiated Solitary Fibrous Tumor: A Concise Review.
Olson NJ, Linos K
Arch Pathol Lab Med 2018 Jun;142(6):761-766. doi: 10.5858/arpa.2016-0570-RS. PMID: 29848035
Doege-Potter Syndrome.
Ahluwalia N, Attia R, Green A, Cane P, Routledge T
Ann R Coll Surg Engl 2015 Oct;97(7):e105-7. doi: 10.1308/rcsann.2015.0023. PMID: 26414372Free PMC Article

Therapy

Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas.
Bonvalot S, Roland C, Raut C, Le Péchoux C, Tzanis D, Frezza AM, Gronchi A
Eur J Surg Oncol 2023 Jun;49(6):1061-1067. Epub 2022 May 16 doi: 10.1016/j.ejso.2022.05.010. PMID: 35599138
Solitary Fibrous Tumor With Extensive Epithelial Inclusions.
Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Solitary-fibrous tumor/hemangiopericytoma of the central nervous system: a population-based study.
Kinslow CJ, Bruce SS, Rae AI, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Sonabend AM, Wang TJC
J Neurooncol 2018 May;138(1):173-182. Epub 2018 Feb 9 doi: 10.1007/s11060-018-2787-7. PMID: 29427152
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051

Prognosis

STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866

Clinical prediction guides

Solitary Fibrous Tumor With Extensive Epithelial Inclusions.
Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Dedifferentiated Solitary Fibrous Tumor: A Concise Review.
Olson NJ, Linos K
Arch Pathol Lab Med 2018 Jun;142(6):761-766. doi: 10.5858/arpa.2016-0570-RS. PMID: 29848035
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866

Recent systematic reviews

Radiological Differentiation Between Intracranial Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma: A Systematic Literature Review.
El-Abtah ME, Murayi R, Lee J, Recinos PF, Kshettry VR
World Neurosurg 2023 Feb;170:68-83. Epub 2022 Nov 18 doi: 10.1016/j.wneu.2022.11.062. PMID: 36403933
Skull base hemangiopericytomas.
Tobias S, Jahshan S, Grober Y, Soustiel JF
Acta Neurol Belg 2022 Dec;122(6):1537-1545. Epub 2021 Sep 30 doi: 10.1007/s13760-021-01812-0. PMID: 34595730
Solitary Fibrous Tumor of the Seminal Vesicle: A Systematic Literature Review and Case Presentation.
Crocetti D, Sapienza P, Lamazza A, DE Felice F, Brachini G, Desiato E, Mingoli A, Fiori E, DE Cesare A
In Vivo 2021 Jul-Aug;35(4):1945-1950. doi: 10.21873/invivo.12461. PMID: 34182467Free PMC Article
Laryngeal Solitary Fibrous Tumor: A Case Report and Systematic Review.
Yang J, Tamares S, Crawley BK
J Voice 2021 Jan;35(1):136-142. Epub 2019 Sep 26 doi: 10.1016/j.jvoice.2019.08.010. PMID: 31500942
Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor.
de Morais EF, Martins HDD, Rodrigues KS, de França GM, da Silveira ÉJD, Freitas RA
Am J Clin Pathol 2020 Jun 8;154(1):15-22. doi: 10.1093/ajcp/aqaa027. PMID: 32134474

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