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Ovarian primitive germ cell tumor

MedGen UID:
275291
•Concept ID:
C1518727
•
Neoplastic Process
Synonyms: Ovarian Primitive Germ Cell Tumor; ovarian primitive germ cell tumor
 
Monarch Initiative: MONDO:0003408

Definition

A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian primitive germ cell tumor

Professional guidelines

PubMed

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359

Recent clinical studies

Etiology

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Germ cell tumors of the ovary: an update.
Nogales FF, Dulcey I, Preda O
Arch Pathol Lab Med 2014 Mar;138(3):351-62. doi: 10.5858/arpa.2012-0547-RA. PMID: 24576031
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512

Diagnosis

Malignant Germ Cell Tumors of the Ovary: Clinical and Imaging Features.
Rogers D, Menias C, Shaaban A
Radiol Clin North Am 2023 Jul;61(4):579-594. Epub 2023 Apr 3 doi: 10.1016/j.rcl.2023.02.004. PMID: 37169425
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Ovarian primary primitive neuroectodermal tumor: a review of cases at PUMCH and in the published literature.
Chao X, Bi Y, Li L
Orphanet J Rare Dis 2019 Jun 19;14(1):147. doi: 10.1186/s13023-019-1106-5. PMID: 31217017Free PMC Article
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795

Therapy

Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Feasibility and safety of adoptive immunotherapy with ex vivo-generated autologous, cytotoxic T lymphocytes in patients with solid tumor.
Montagna D, Turin I, Schiavo R, Montini E, Zaffaroni N, Villa R, Secondino S, Schiavetto I, Caliogna L, Locatelli F, Libri V, Pession A, Tonelli R, Maccario R, Siena S, Pedrazzoli P
Cytotherapy 2012 Jan;14(1):80-90. Epub 2011 Sep 23 doi: 10.3109/14653249.2011.610303. PMID: 21942841
Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study.
Marina NM, Cushing B, Giller R, Cohen L, Lauer SJ, Ablin A, Weetman R, Cullen J, Rogers P, Vinocur C, Stolar C, Rescorla F, Hawkins E, Heifetz S, Rao PV, Krailo M, Castleberry RP
J Clin Oncol 1999 Jul;17(7):2137-43. doi: 10.1200/JCO.1999.17.7.2137. PMID: 10561269
Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359

Prognosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Ovarian primary primitive neuroectodermal tumor: a review of cases at PUMCH and in the published literature.
Chao X, Bi Y, Li L
Orphanet J Rare Dis 2019 Jun 19;14(1):147. doi: 10.1186/s13023-019-1106-5. PMID: 31217017Free PMC Article
Discovery and diagnostic value of a novel oncofetal protein: glypican 3.
Wang SK, Zynger DL, Hes O, Yang XJ
Adv Anat Pathol 2014 Nov;21(6):450-60. doi: 10.1097/PAP.0000000000000043. PMID: 25299314
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359

Clinical prediction guides

Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature.
Tîrnovanu MC, Florea ID, Tănase A, Toma BF, Cojocaru E, Ungureanu C, Lozneanu L
Medicina (Kaunas) 2021 May 27;57(6) doi: 10.3390/medicina57060534. PMID: 34071828Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Discovery and diagnostic value of a novel oncofetal protein: glypican 3.
Wang SK, Zynger DL, Hes O, Yang XJ
Adv Anat Pathol 2014 Nov;21(6):450-60. doi: 10.1097/PAP.0000000000000043. PMID: 25299314
Spectrum of germ cell tumors: from head to toe.
Ueno T, Tanaka YO, Nagata M, Tsunoda H, Anno I, Ishikawa S, Kawai K, Itai Y
Radiographics 2004 Mar-Apr;24(2):387-404. doi: 10.1148/rg.242035082. PMID: 15026588
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

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