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Recurrent Malignant Extragonadal Germ Cell Tumor

MedGen UID:
857330
•Concept ID:
C3897736
•
Neoplastic Process

Definition

The reemergence of malignant extragonadal germ cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Extragonadal Germ Cell Tumor

Professional guidelines

PubMed

Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy.
Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J, Beintker M, Beyersdorff D, Bokemeyer C, Busch J, Classen J, de Wit M, Dieckmann KP, Diemer T, Dieing A, Gockel M, Göckel-Beining B, Hakenberg OW, Heidenreich A, Heinzelbecker J, Herkommer K, Hermanns T, Kaufmann S, Kornmann M, Kotzerke J, Krege S, Kristiansen G, Lorch A, Müller AC, Oechsle K, Ohloff T, Oing C, Otto U, Pfister D, Pichler R, Recken H, Rick O, Rudolph Y, Ruf C, Schirren J, Schmelz H, Schmidberger H, Schrader M, Schweyer S, Seeling S, Souchon R, Winter C, Wittekind C, Zengerling F, Zermann DH, Zillmann R, Albers P
Urol Int 2021;105(3-4):181-191. Epub 2021 Jan 22 doi: 10.1159/000511245. PMID: 33486494Free PMC Article
Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017.
Fumino S, Tajiri T, Usui N, Tamura M, Sago H, Ono S, Nosaka S, Yoneda A, Souzaki R, Higashi M, Sakai K, Takahashi K, Sugiura T, Taguchi T
Pediatr Int 2019 Jul;61(7):672-678. Epub 2019 Jun 18 doi: 10.1111/ped.13844. PMID: 30903638
Adult primary extragonadal germ cell tumors: Treatment results and long-term follow-up.
Andac A, Mert B, Sevil B, Burak S, Haluk O
Med Pediatr Oncol 2003 Jul;41(1):49-53. doi: 10.1002/mpo.10136. PMID: 12764743

Recent clinical studies

Etiology

Sacrococcygeal teratomas: a case-based review from the perspective of individual multidisciplinary experts.
Mosleh MM, Heo TG, Shin HB, Sohn MJ
Childs Nerv Syst 2023 Jan;39(1):57-64. Epub 2022 Nov 24 doi: 10.1007/s00381-022-05768-1. PMID: 36422695
Mature cystic teratoma mimicking meningomyelocele.
Balci M, Yuksel U, Akkaya MA, Akkaya S, Sagsoz N
Childs Nerv Syst 2021 Jul;37(7):2245-2249. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05017-3. PMID: 33404722
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491
Germ cell tumors.
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272

Diagnosis

Sacrococcygeal teratomas: a case-based review from the perspective of individual multidisciplinary experts.
Mosleh MM, Heo TG, Shin HB, Sohn MJ
Childs Nerv Syst 2023 Jan;39(1):57-64. Epub 2022 Nov 24 doi: 10.1007/s00381-022-05768-1. PMID: 36422695
Mature cystic teratoma mimicking meningomyelocele.
Balci M, Yuksel U, Akkaya MA, Akkaya S, Sagsoz N
Childs Nerv Syst 2021 Jul;37(7):2245-2249. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05017-3. PMID: 33404722
Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491

Therapy

Late testicular relapse two decades after primary extragonadal germ cell tumor with uncommon metastases: a case report.
Tobiume M, Aoki S, Nishikawa G, Muramatsu H, Ono K, Morinaga S, Hara K, Ando N, Ono K, Nishibata C, Hidano A, Nakagawa M, Takahashi I, Matsubara K, Yamada Y
J Med Case Rep 2021 Feb 5;15(1):59. doi: 10.1186/s13256-021-02667-y. PMID: 33541424Free PMC Article
Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Primary mediastinal and retroperitoneal malignant germ cell tumors in children and adolescents: Results of the TGM95 trial, a study of the French Society of Pediatric Oncology (Société Française des Cancers de l'Enfant).
Sudour-Bonnange H, Faure-Conter C, Martelli H, Hameury F, Fresneau B, Orbach D, Vérité C
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Mar 17 doi: 10.1002/pbc.26494. PMID: 28306215
Adult primary extragonadal germ cell tumors: Treatment results and long-term follow-up.
Andac A, Mert B, Sevil B, Burak S, Haluk O
Med Pediatr Oncol 2003 Jul;41(1):49-53. doi: 10.1002/mpo.10136. PMID: 12764743
Salvage therapy in recurrent germ cell cancer: ifosfamide and cisplatin plus either vinblastine or etoposide.
Loehrer PJ Sr, Lauer R, Roth BJ, Williams SD, Kalasinski LA, Einhorn LH
Ann Intern Med 1988 Oct 1;109(7):540-6. doi: 10.7326/0003-4819-109-7-540. PMID: 2844110

Prognosis

Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Late relapse of nonseminomatous germ cell tumours.
Oldenburg J, Fosså SD
BJU Int 2009 Nov;104(9 Pt B):1413-7. doi: 10.1111/j.1464-410X.2009.08868.x. PMID: 19840022
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Adult primary extragonadal germ cell tumors: Treatment results and long-term follow-up.
Andac A, Mert B, Sevil B, Burak S, Haluk O
Med Pediatr Oncol 2003 Jul;41(1):49-53. doi: 10.1002/mpo.10136. PMID: 12764743
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491

Clinical prediction guides

Postoperative recurrence of mixed extragonadal germ cell tumor in the right shoulder: a case report.
Li Y, Huang X, Meng X, Luo Y, Luo S, Wang J
Diagn Pathol 2023 Feb 20;18(1):26. doi: 10.1186/s13000-023-01312-0. PMID: 36805679Free PMC Article
Mature cystic teratoma mimicking meningomyelocele.
Balci M, Yuksel U, Akkaya MA, Akkaya S, Sagsoz N
Childs Nerv Syst 2021 Jul;37(7):2245-2249. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05017-3. PMID: 33404722
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Germ cell tumors.
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

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