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Microvascular complications of diabetes, susceptibility

MedGen UID:
1034754
•Concept ID:
CN357508
•
Disease or Syndrome
Synonym: Microvascular complications of diabetes
 
Related genes: VEGFA, SOD2, PON1, IL1RN, EPO, ACE
 
Monarch Initiative: MONDO:0000065
OMIM® Phenotypic series: PS603933

Professional guidelines

PubMed

Identifying Genetic Risk Factors for Diabetic Macular Edema and the Response to Treatment.
Gurung RL, FitzGerald LM, McComish BJ, Verma N, Burdon KP
J Diabetes Res 2020;2020:5016916. Epub 2020 Nov 12 doi: 10.1155/2020/5016916. PMID: 33274237Free PMC Article
Oxidative stress and diabetic retinopathy: development and treatment.
Calderon GD, Juarez OH, Hernandez GE, Punzo SM, De la Cruz ZD
Eye (Lond) 2017 Aug;31(8):1122-1130. Epub 2017 Apr 28 doi: 10.1038/eye.2017.64. PMID: 28452994Free PMC Article
The diabetic foot management - recent advance.
Sinwar PD
Int J Surg 2015 Mar;15:27-30. Epub 2015 Jan 29 doi: 10.1016/j.ijsu.2015.01.023. PMID: 25638739

Recent clinical studies

Etiology

Genetics of diabetes-associated microvascular complications.
Lyssenko V, Vaag A
Diabetologia 2023 Sep;66(9):1601-1613. Epub 2023 Jul 14 doi: 10.1007/s00125-023-05964-x. PMID: 37452207Free PMC Article
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy.
Dewanjee S, Vallamkondu J, Kalra RS, John A, Reddy PH, Kandimalla R
Ageing Res Rev 2021 Jul;68:101338. Epub 2021 Apr 7 doi: 10.1016/j.arr.2021.101338. PMID: 33838320
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Risk factors for type 2 diabetes mellitus.
Fletcher B, Gulanick M, Lamendola C
J Cardiovasc Nurs 2002 Jan;16(2):17-23. doi: 10.1097/00005082-200201000-00003. PMID: 11800065

Diagnosis

Inflammatory and angiogenic biomarkers in diabetic retinopathy.
Kaštelan S, Orešković I, Bišćan F, Kaštelan H, Gverović Antunica A
Biochem Med (Zagreb) 2020 Oct 15;30(3):030502. Epub 2020 Aug 5 doi: 10.11613/BM.2020.030502. PMID: 32774120Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Lest we forget the microvascular complications of diabetes.
Holt RIG
Diabet Med 2018 Oct;35(10):1307. doi: 10.1111/dme.13807. PMID: 30246343
Diabetic nephropathy--emerging epigenetic mechanisms.
Kato M, Natarajan R
Nat Rev Nephrol 2014 Sep;10(9):517-30. Epub 2014 Jul 8 doi: 10.1038/nrneph.2014.116. PMID: 25003613Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Therapy

The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Oxidative stress and diabetic retinopathy: development and treatment.
Calderon GD, Juarez OH, Hernandez GE, Punzo SM, De la Cruz ZD
Eye (Lond) 2017 Aug;31(8):1122-1130. Epub 2017 Apr 28 doi: 10.1038/eye.2017.64. PMID: 28452994Free PMC Article
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article
Fibrates and microvascular complications in diabetes--insight from the FIELD study.
Ansquer JC, Foucher C, Aubonnet P, Le Malicot K
Curr Pharm Des 2009;15(5):537-52. doi: 10.2174/138161209787315701. PMID: 19199980

Prognosis

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Tropical chronic pancreatitis.
Barman KK, Premalatha G, Mohan V
Postgrad Med J 2003 Nov;79(937):606-15. doi: 10.1136/pmj.79.937.606. PMID: 14654569Free PMC Article

Clinical prediction guides

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
Banerjee J, Nema V, Dhas Y, Mishra N
Biochimie 2017 Aug;139:9-19. Epub 2017 May 6 doi: 10.1016/j.biochi.2017.05.007. PMID: 28487136
Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models.
McKay GJ, Teo BW, Zheng YF, Sambamoorthi U, Sabanayagam C
J Diabetes Res 2016;2016:2172106. Epub 2015 Dec 8 doi: 10.1155/2016/2172106. PMID: 26779541Free PMC Article
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article

Recent systematic reviews

Clinical and Genetic Characteristics of ABCC8 Nonneonatal Diabetes Mellitus: A Systematic Review.
Li M, Han X, Ji L
J Diabetes Res 2021;2021:9479268. Epub 2021 Sep 30 doi: 10.1155/2021/9479268. PMID: 34631896Free PMC Article
Association between polymorphisms of cytokine genes and diabetic nephropathy: A comprehensive systematic review and meta-analysis.
Wu J, Jiang C, Hua Y, Liu X, You C
Int J Clin Pract 2021 Nov;75(11):e14634. Epub 2021 Aug 8 doi: 10.1111/ijcp.14634. PMID: 34309136
(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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