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Microvascular complications of diabetes, susceptibility to, 4(MVCD4)

MedGen UID:
382527
•Concept ID:
C2675112
•
Finding
Synonym: Microvascular complications of diabetes 4
 
Gene (location): IL1RN (2q14.1)
 
Monarch Initiative: MONDO:0012966
OMIM®: 612628

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the IL1RN gene. [from MONDO]

Professional guidelines

PubMed

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T; Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Diabetes Res Clin Pract 2002 Jan;55(1):65-85. doi: 10.1016/s0168-8227(01)00365-5. PMID: 11755481

Recent clinical studies

Etiology

Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Recent advances in exploring the genetic susceptibility to diabetic neuropathy.
Politi C, Ciccacci C, D'Amato C, Novelli G, Borgiani P, Spallone V
Diabetes Res Clin Pract 2016 Oct;120:198-208. Epub 2016 Aug 26 doi: 10.1016/j.diabres.2016.08.006. PMID: 27596057
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Diagnosis

Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.
Mansour A, Mousa M, Abdelmannan D, Tay G, Hassoun A, Alsafar H
Front Endocrinol (Lausanne) 2023;14:1143067. Epub 2023 Mar 23 doi: 10.3389/fendo.2023.1143067. PMID: 37033211Free PMC Article
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Perspectives on systems biology applications in diabetic kidney disease.
Komorowsky CV, Brosius FC 3rd, Pennathur S, Kretzler M
J Cardiovasc Transl Res 2012 Aug;5(4):491-508. Epub 2012 Jun 26 doi: 10.1007/s12265-012-9382-7. PMID: 22733404Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Therapy

Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Zhou J, Xu B, He F, Shu Y, Chen X, Liu Z, Sun B, Zhang W
Cardiovasc Diabetol 2024 May 10;23(1):166. doi: 10.1186/s12933-024-02267-2. PMID: 38730425Free PMC Article
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Fu H, Guo C, Zhang J, Xu L, Jiang S, Guo S, Sheng Q, Zhao J, Liao L
IUBMB Life 2023 Jul;75(7):624-642. Epub 2023 Mar 1 doi: 10.1002/iub.2711. PMID: 36856001
Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring.
Hermans MP, Ahn SA, Rousseau MF
J Diabetes 2019 Apr;11(4):301-308. Epub 2018 Sep 23 doi: 10.1111/1753-0407.12840. PMID: 30105804
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
PAI-1 4G/5G insertion/deletion promoter polymorphism and microvascular complications in type 2 diabetes mellitus.
Funk M, Endler G, Exner M, Marculescu R, Endler L, Abrahamian H, Mauler H, Grimm A, Raith M, Mannhalter C, Prager R, Irsigler K, Wagner OF
Wien Klin Wochenschr 2005 Oct;117(19-20):707-10. doi: 10.1007/s00508-005-0425-9. PMID: 16416371

Prognosis

Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Recent advances in exploring the genetic susceptibility to diabetic neuropathy.
Politi C, Ciccacci C, D'Amato C, Novelli G, Borgiani P, Spallone V
Diabetes Res Clin Pract 2016 Oct;120:198-208. Epub 2016 Aug 26 doi: 10.1016/j.diabres.2016.08.006. PMID: 27596057
Functional relevance of genetic variations of endothelial nitric oxide synthase and vascular endothelial growth factor in diabetic coronary microvessel dysfunction.
Joshi MS, Berger PJ, Kaye DM, Pearson JT, Bauer JA, Ritchie RH
Clin Exp Pharmacol Physiol 2013 Apr;40(4):253-61. doi: 10.1111/1440-1681.12070. PMID: 23448535
Perspectives on systems biology applications in diabetic kidney disease.
Komorowsky CV, Brosius FC 3rd, Pennathur S, Kretzler M
J Cardiovasc Transl Res 2012 Aug;5(4):491-508. Epub 2012 Jun 26 doi: 10.1007/s12265-012-9382-7. PMID: 22733404Free PMC Article

Clinical prediction guides

Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
Diabetic Retinopathy in the Context of Patients with Diabetes.
Simó-Servat O, Hernández C, Simó R
Ophthalmic Res 2019;62(4):211-217. Epub 2019 May 24 doi: 10.1159/000499541. PMID: 31129667
Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring.
Hermans MP, Ahn SA, Rousseau MF
J Diabetes 2019 Apr;11(4):301-308. Epub 2018 Sep 23 doi: 10.1111/1753-0407.12840. PMID: 30105804
Recent advances in exploring the genetic susceptibility to diabetic neuropathy.
Politi C, Ciccacci C, D'Amato C, Novelli G, Borgiani P, Spallone V
Diabetes Res Clin Pract 2016 Oct;120:198-208. Epub 2016 Aug 26 doi: 10.1016/j.diabres.2016.08.006. PMID: 27596057
Diabetes and infection: assessing the association with glycaemic control in population-based studies.
Pearson-Stuttard J, Blundell S, Harris T, Cook DG, Critchley J
Lancet Diabetes Endocrinol 2016 Feb;4(2):148-58. Epub 2015 Dec 3 doi: 10.1016/S2213-8587(15)00379-4. PMID: 26656292

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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      OMIM records containing genes associated with phenotypes registered in MedGen
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