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Vulvar carcinoma

MedGen UID:
146159
•Concept ID:
C0677055
•
Neoplastic Process
Synonyms: Cancer of the Vulva; Cancer of Vulva; carcinoma of mammalian vulva; Carcinoma of the Vulva; carcinoma of the vulva; Carcinoma of Vulva; Carcinoma of vulva; carcinoma of vulva; mammalian vulva carcinoma; Vulva Cancer; Vulva Carcinoma; vulva carcinoma; Vulvar Cancer; Vulvar Carcinoma; vulvar carcinoma
 
Monarch Initiative: MONDO:0005215
Orphanet: ORPHA494418

Definition

A group of rare tumors of the vulva comprising HPV-associated and HPV-independent squamous cell carcinomas as the most frequent malignant vulvar tumors, basal cell carcinomas, adenocarcinomas, and Bartholin gland carcinomas. Depending on the type of tumor and disease stage, patients may present with a painless vulvar mass or ulcer, or with pruritus, a burning sensation, pain, or bleeding. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar carcinoma

Professional guidelines

PubMed

Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Role of chemotherapy in the management of vulvar carcinoma.
Tomao F, Di Tucci C, Marchetti C, Perniola G, Bellati F, Panici PB
Crit Rev Oncol Hematol 2012 Apr;82(1):25-39. Epub 2011 May 20 doi: 10.1016/j.critrevonc.2011.04.008. PMID: 21601474

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

Recent clinical studies

Etiology

Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Key concepts in management of vulvar cancer.
Zweizig S, Korets S, Cain JM
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):959-66. Epub 2014 Jul 17 doi: 10.1016/j.bpobgyn.2014.07.001. PMID: 25151473
Penile carcinoma: lessons learned from vulvar carcinoma.
Longpre MJ, Lange PH, Kwon JS, Black PC
J Urol 2013 Jan;189(1):17-24. Epub 2012 Nov 16 doi: 10.1016/j.juro.2012.08.082. PMID: 23158472
Vulvar carcinoma.
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056
Vulvar carcinoma.
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Diagnosis

Vulvar Carcinoma: Standard of Care and Perspectives.
Chargari C, Wasserman J, Gabro A, Canlobre G, Spano JP, Uzan C, Maingon P
J Clin Oncol 2024 Mar 10;42(8):961-972. Epub 2024 Feb 5 doi: 10.1200/JCO.23.01187. PMID: 38315939
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Paget disease of the vulva.
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063
Vulvar ulcers and vulvar carcinoma.
Schwartz PE
Menopause 2011 Oct;18(10):1042-3. doi: 10.1097/gme.0b013e31822a8966. PMID: 22046600
Vulvar carcinoma.
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Therapy

Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial.
Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Targeted therapies for rare gynaecological cancers.
Manchana T, Ittiwut C, Mutirangura A, Kavanagh JJ
Lancet Oncol 2010 Jul;11(7):685-93. Epub 2010 Mar 31 doi: 10.1016/S1470-2045(09)70368-7. PMID: 20362508
Vulvar carcinoma.
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056
Gynecologic cancers.
Boente MP, Schilder R, Ozols RF
Cancer Chemother Biol Response Modif 1997;17:536-61. PMID: 9551230

Prognosis

Vulvar Carcinoma: Standard of Care and Perspectives.
Chargari C, Wasserman J, Gabro A, Canlobre G, Spano JP, Uzan C, Maingon P
J Clin Oncol 2024 Mar 10;42(8):961-972. Epub 2024 Feb 5 doi: 10.1200/JCO.23.01187. PMID: 38315939
Preoperative elevated platelet count and thrombocytosis in gynecologic malignancies.
Menczer J
Arch Gynecol Obstet 2017 Jan;295(1):9-15. Epub 2016 Oct 6 doi: 10.1007/s00404-016-4212-9. PMID: 27714462
Paget disease of the vulva.
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Vulvar carcinoma.
Anderson JM, Cassady JR, Shimm DS, Stea B
Int J Radiat Oncol Biol Phys 1995 Jul 30;32(5):1351-7. doi: 10.1016/0360-3016(95)00090-L. PMID: 7635775

Clinical prediction guides

High-grade vulvar intraepithelial neoplasia: comprehensive characterization and long-term vulvar carcinoma risk.
Thuijs NB, van Beurden M, Duin S, Heideman DAM, Berkhof J, Steenbergen RDM, Bleeker MCG
Histopathology 2024 Jan;84(2):301-314. Epub 2023 Sep 19 doi: 10.1111/his.15050. PMID: 37726173
Genes, pathways and vulvar carcinoma - New insights from next-generation sequencing studies.
Zięba S, Chechlińska M, Kowalik A, Kowalewska M
Gynecol Oncol 2020 Aug;158(2):498-506. Epub 2020 Jun 7 doi: 10.1016/j.ygyno.2020.05.034. PMID: 32522421
Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial.
Naumann RW, Hollebecque A, Meyer T, Devlin MJ, Oaknin A, Kerger J, López-Picazo JM, Machiels JP, Delord JP, Evans TRJ, Boni V, Calvo E, Topalian SL, Chen T, Soumaoro I, Li B, Gu J, Zwirtes R, Moore KN
J Clin Oncol 2019 Nov 1;37(31):2825-2834. Epub 2019 Sep 5 doi: 10.1200/JCO.19.00739. PMID: 31487218Free PMC Article
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Epidemiology of vulvar and vaginal cancer in Germany.
Dittmer C, Katalinic A, Mundhenke C, Thill M, Fischer D
Arch Gynecol Obstet 2011 Jul;284(1):169-74. Epub 2011 Feb 22 doi: 10.1007/s00404-011-1850-9. PMID: 21340687

Recent systematic reviews

Management of primary and recurrent Bartholin's gland carcinoma: A systematic review on behalf of MITO Rare Cancer Group.
Turetta C, Mazzeo R, Capalbo G, Miano S, Fruscio R, Di Donato V, Falcone F, Mangili G, Pignata S, Palaia I
Tumori 2024 Apr;110(2):96-108. Epub 2023 Nov 13 doi: 10.1177/03008916231208308. PMID: 37953636
The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul.Can multidisciplinary team systematic review.
Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029
Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review.
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Vulvar cancer: initial management and systematic review of literature on currently applied treatment approaches.
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients.
van Seters M, van Beurden M, de Craen AJ
Gynecol Oncol 2005 May;97(2):645-51. doi: 10.1016/j.ygyno.2005.02.012. PMID: 15863172

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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