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Decreased proportion of memory T cells

MedGen UID:
1689962
•Concept ID:
C5139180
•
Finding
Synonym: Decreased proportion of CD4+CD29+ cells
 
HPO: HP:0032183

Definition

An abnormally reduced proportion of memory T cells compared to the total number of T cells in the blood. [from HPO]

Professional guidelines

PubMed

Peripheral memory T-cell profile is modified in patients undergoing periodontal management.
Medara N, Lenzo JC, Walsh KA, Holden JA, Reynolds EC, Darby IB, O'Brien-Simpson NM
J Clin Periodontol 2021 Feb;48(2):249-262. Epub 2020 Nov 22 doi: 10.1111/jcpe.13399. PMID: 33131124
Evaluation of antitumor immunity by a combination treatment of high-dose irradiation, anti-PDL1, and anti-angiogenic therapy in murine lung tumors.
Chen JL, Pan CK, Huang YS, Tsai CY, Wang CW, Lin YL, Kuo SH, Shieh MJ
Cancer Immunol Immunother 2021 Feb;70(2):391-404. Epub 2020 Aug 6 doi: 10.1007/s00262-020-02690-w. PMID: 32761424Free PMC Article
CD147 blockade as a potential and novel treatment of graft rejection.
Luan J, Zhao Y, Zhang Y, Miao J, Li J, Chen ZN, Zhu P
Mol Med Rep 2017 Oct;16(4):4593-4602. Epub 2017 Aug 9 doi: 10.3892/mmr.2017.7201. PMID: 28849101Free PMC Article

Recent clinical studies

Etiology

Nanovaccines Fostering Tertiary Lymphoid Structure to Attack Mimicry Nasopharyngeal Carcinoma.
Wen Z, Liu H, Qiao D, Chen H, Li L, Yang Z, Zhu C, Zeng Z, Chen Y, Liu L
ACS Nano 2023 Apr 25;17(8):7194-7206. Epub 2023 Apr 14 doi: 10.1021/acsnano.2c09619. PMID: 37057967
Role of thymus in health and disease.
Gulla S, Reddy MC, Reddy VC, Chitta S, Bhanoori M, Lomada D
Int Rev Immunol 2023;42(5):347-363. Epub 2022 May 20 doi: 10.1080/08830185.2022.2064461. PMID: 35593192
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma.
Wang T, Shi J, Li L, Zhou X, Zhang H, Zhang X, Wang Y, Liu L, Sheng L
Front Immunol 2022;13:840811. Epub 2022 Apr 20 doi: 10.3389/fimmu.2022.840811. PMID: 35515000Free PMC Article
Phenotype and function of circulating memory T cells in human vitiligo.
Martins C, Darrigade AS, Jacquemin C, Barnetche T, Taieb A, Ezzedine K, Boniface K, Seneschal J
Br J Dermatol 2020 Nov;183(5):899-908. Epub 2020 Mar 9 doi: 10.1111/bjd.18902. PMID: 32012221

Diagnosis

Role of thymus in health and disease.
Gulla S, Reddy MC, Reddy VC, Chitta S, Bhanoori M, Lomada D
Int Rev Immunol 2023;42(5):347-363. Epub 2022 May 20 doi: 10.1080/08830185.2022.2064461. PMID: 35593192
Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma.
Wang T, Shi J, Li L, Zhou X, Zhang H, Zhang X, Wang Y, Liu L, Sheng L
Front Immunol 2022;13:840811. Epub 2022 Apr 20 doi: 10.3389/fimmu.2022.840811. PMID: 35515000Free PMC Article
Altered leukocyte subsets and immune proteome indicate proinflammatory mechanisms in mastocytosis.
Hermans MAW, Heeringa JJ, Swagemakers SGA, Schrijver B, van Daele PLA, van der Spek PJ, van Hagen PM, van Zelm MC, Dik WA
J Allergy Clin Immunol 2022 Jul;150(1):146-156.e10. Epub 2022 Jan 10 doi: 10.1016/j.jaci.2021.12.786. PMID: 35026208
Immune memory limits human longevity: the role of memory СD4+ T cells in age-related immune abnormalities.
Seledtsov VI, von Delwig AA
Expert Rev Vaccines 2020 Mar;19(3):209-215. Epub 2020 Apr 6 doi: 10.1080/14760584.2020.1745638. PMID: 32191535
Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly.
Saavedra D, Fuertes SA, Suárez GM, González A, Lorenzo-Luaces P, García B, Aznar E, Mazorra Z, Crombet T, Speiser DE, Lage A
Exp Gerontol 2019 Sep;124:110633. Epub 2019 Jun 14 doi: 10.1016/j.exger.2019.110633. PMID: 31207285

Therapy

Hydroxychloroquine reduces T cells activation recall antigen responses.
Kowatsch MM, Lajoie J, Mwangi L, Omollo K, Oyugi J, Hollett N, Kimani J, Fowke KR
PLoS One 2023;18(8):e0287738. Epub 2023 Aug 2 doi: 10.1371/journal.pone.0287738. PMID: 37531383Free PMC Article
Intratumor childhood vaccine-specific CD4(+) T-cell recall coordinates antitumor CD8(+) T cells and eosinophils.
Brown MC, Beasley GM, McKay ZP, Yang Y, Desjardins A, Randazzo DM, Landi D, Ashley DM, Bigner DD, Nair SK, Gromeier M
J Immunother Cancer 2023 Apr;11(4) doi: 10.1136/jitc-2022-006463. PMID: 37072349Free PMC Article
Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly.
Saavedra D, Fuertes SA, Suárez GM, González A, Lorenzo-Luaces P, García B, Aznar E, Mazorra Z, Crombet T, Speiser DE, Lage A
Exp Gerontol 2019 Sep;124:110633. Epub 2019 Jun 14 doi: 10.1016/j.exger.2019.110633. PMID: 31207285
Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4(+) and CD8(+) T-Cells.
Gorchs L, Fernández Moro C, Bankhead P, Kern KP, Sadeak I, Meng Q, Rangelova E, Kaipe H
Front Immunol 2019;10:847. Epub 2019 Apr 24 doi: 10.3389/fimmu.2019.00847. PMID: 31068935Free PMC Article
Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.
Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
Cancer Sci 2017 Sep;108(9):1739-1745. Epub 2017 Aug 7 doi: 10.1111/cas.13319. PMID: 28699227Free PMC Article

Prognosis

Nanovaccines Fostering Tertiary Lymphoid Structure to Attack Mimicry Nasopharyngeal Carcinoma.
Wen Z, Liu H, Qiao D, Chen H, Li L, Yang Z, Zhu C, Zeng Z, Chen Y, Liu L
ACS Nano 2023 Apr 25;17(8):7194-7206. Epub 2023 Apr 14 doi: 10.1021/acsnano.2c09619. PMID: 37057967
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma.
Wang T, Shi J, Li L, Zhou X, Zhang H, Zhang X, Wang Y, Liu L, Sheng L
Front Immunol 2022;13:840811. Epub 2022 Apr 20 doi: 10.3389/fimmu.2022.840811. PMID: 35515000Free PMC Article
Altered circulating CCR6(+)and CXCR3(+) T cell subsets are associated with poor renal prognosis in MPO-ANCA-associated vasculitis.
Liao Z, Tang J, Luo L, Deng S, Luo L, Wang F, Yuan X, Hu X, Feng J, Li X
Arthritis Res Ther 2021 Jul 21;23(1):194. doi: 10.1186/s13075-021-02576-x. PMID: 34289887Free PMC Article
Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.
Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
Cancer Sci 2017 Sep;108(9):1739-1745. Epub 2017 Aug 7 doi: 10.1111/cas.13319. PMID: 28699227Free PMC Article

Clinical prediction guides

Hydroxychloroquine reduces T cells activation recall antigen responses.
Kowatsch MM, Lajoie J, Mwangi L, Omollo K, Oyugi J, Hollett N, Kimani J, Fowke KR
PLoS One 2023;18(8):e0287738. Epub 2023 Aug 2 doi: 10.1371/journal.pone.0287738. PMID: 37531383Free PMC Article
Intratumor childhood vaccine-specific CD4(+) T-cell recall coordinates antitumor CD8(+) T cells and eosinophils.
Brown MC, Beasley GM, McKay ZP, Yang Y, Desjardins A, Randazzo DM, Landi D, Ashley DM, Bigner DD, Nair SK, Gromeier M
J Immunother Cancer 2023 Apr;11(4) doi: 10.1136/jitc-2022-006463. PMID: 37072349Free PMC Article
Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.
Yuan S, Zeng Y, Li J, Wang C, Li W, He Z, Ye J, Li F, Chen Y, Lin X, Yu N, Cai X
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000660. PMID: 35732344Free PMC Article
Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma.
Wang T, Shi J, Li L, Zhou X, Zhang H, Zhang X, Wang Y, Liu L, Sheng L
Front Immunol 2022;13:840811. Epub 2022 Apr 20 doi: 10.3389/fimmu.2022.840811. PMID: 35515000Free PMC Article
Phenotype and function of circulating memory T cells in human vitiligo.
Martins C, Darrigade AS, Jacquemin C, Barnetche T, Taieb A, Ezzedine K, Boniface K, Seneschal J
Br J Dermatol 2020 Nov;183(5):899-908. Epub 2020 Mar 9 doi: 10.1111/bjd.18902. PMID: 32012221

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