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Non-Neoplastic Pharyngeal Disorder

MedGen UID:
233780
•Concept ID:
C1335032
•
Disease or Syndrome
Synonym: Non-Neoplastic Pharyngeal Disease

Definition

A non-neoplastic disorder that affects the pharynx. Representative examples include pharyngitis and mucositis. [from NCI]

Professional guidelines

PubMed

Medical management of non-neoplastic salivary gland disease.
Stuchell RN, Blitzer A, Mandel ID
Otolaryngol Clin North Am 1984 Nov;17(4):697-703. PMID: 6514360
Diagnosis and differential diagnosis of lymphoepithelial carcinoma in lymph nodes: histological, cytological and electron-microscopic findings.
Lennert K, Kaiserling E, Mazzanti T
IARC Sci Publ (1971) 1978;(20):51-64. PMID: 83286

Recent clinical studies

Etiology

Diet Quality as Measured by the Healthy Eating Index 2015 and Oral and Pharyngeal Cancer Risk.
Edefonti V, Di Maso M, Tomaino L, Parpinel M, Garavello W, Serraino D, Ferraroni M, Crispo A, La Vecchia C, Bravi F
J Acad Nutr Diet 2022 Sep;122(9):1677-1687.e5. Epub 2021 Jun 11 doi: 10.1016/j.jand.2021.04.020. PMID: 34127426
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology.
Hamdan AL, Khalifee E, Jaffal H, Ghanem A, Rizk SA, El Hage A
J Voice 2019 Sep;33(5):708-711. Epub 2018 Jun 5 doi: 10.1016/j.jvoice.2018.05.003. PMID: 29884508
Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy.
Shivappa N, Hébert JR, Rosato V, Garavello W, Serraino D, La Vecchia C
Int J Cancer 2017 Aug 1;141(3):471-479. Epub 2017 May 9 doi: 10.1002/ijc.30711. PMID: 28340515Free PMC Article
Human papilloma virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in Taiwan.
Huang CC, Hsiao JR, Yang MW, Wu YH, Hsu KF, Chang Y, Chen CW, Tsai ST, Wei HP, Jin YT
J Clin Pathol 2011 Jul;64(7):571-7. Epub 2011 Apr 21 doi: 10.1136/jcp.2010.087742. PMID: 21512108
Folate intake and risk of oral and pharyngeal cancer.
Pelucchi C, Talamini R, Negri E, Levi F, Conti E, Franceschi S, La Vecchia C
Ann Oncol 2003 Nov;14(11):1677-81. doi: 10.1093/annonc/mdg448. PMID: 14581278

Diagnosis

Primary laryngeal cryptococcosis mimicking laryngeal malignancy: a case report.
Tonai K, Nishio N, Yokoi S, Kobayashi M, Sone M
Nagoya J Med Sci 2022 Nov;84(4):900-905. doi: 10.18999/nagjms.84.4.900. PMID: 36544607Free PMC Article
CD163 Immunohistochemical "Circle Sign" Staining Pattern Differentiates Sinonasal Papillomas From Morphologically Similar Non-neoplastic Lesions.
Sterling BC, Mehrad M, Ely KA, Lewis JS Jr
Am J Surg Pathol 2022 Nov 1;46(11):1507-1513. Epub 2022 Aug 23 doi: 10.1097/PAS.0000000000001953. PMID: 35993580Free PMC Article
Histopathology of Sinonasal and Nasopharyngeal Neoplastic Lesions in a Tertiary Care Center of Western Nepal: A Descriptive Cross-sectional Study.
Regmi S, Ghosh A, Gharti Magar D, Thapa S, Koirala KP, Talwar OP
JNMA J Nepal Med Assoc 2021 Jul 30;59(239):657-662. doi: 10.31729/jnma.6859. PMID: 34508496Free PMC Article
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology.
Hamdan AL, Khalifee E, Jaffal H, Ghanem A, Rizk SA, El Hage A
J Voice 2019 Sep;33(5):708-711. Epub 2018 Jun 5 doi: 10.1016/j.jvoice.2018.05.003. PMID: 29884508
Imaging of the larynx and hypopharynx.
Becker M, Burkhardt K, Dulguerov P, Allal A
Eur J Radiol 2008 Jun;66(3):460-79. Epub 2008 May 20 doi: 10.1016/j.ejrad.2008.03.027. PMID: 18495402

Therapy

Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy.
Shivappa N, Hébert JR, Rosato V, Garavello W, Serraino D, La Vecchia C
Int J Cancer 2017 Aug 1;141(3):471-479. Epub 2017 May 9 doi: 10.1002/ijc.30711. PMID: 28340515Free PMC Article
Nutrient-based dietary patterns and the risk of oral and pharyngeal cancer.
Edefonti V, Bravi F, La Vecchia C, Randi G, Ferraroni M, Garavello W, Franceschi S, Talamini R, Boffetta P, Decarli A
Oral Oncol 2010 May;46(5):343-8. Epub 2010 Mar 11 doi: 10.1016/j.oraloncology.2009.11.017. PMID: 20226721
Role of fried foods and oral/pharyngeal and oesophageal cancers.
Galeone C, Pelucchi C, Talamini R, Levi F, Bosetti C, Negri E, Franceschi S, La Vecchia C
Br J Cancer 2005 Jun 6;92(11):2065-9. doi: 10.1038/sj.bjc.6602542. PMID: 15856044Free PMC Article
Folate intake and risk of oral and pharyngeal cancer.
Pelucchi C, Talamini R, Negri E, Levi F, Conti E, Franceschi S, La Vecchia C
Ann Oncol 2003 Nov;14(11):1677-81. doi: 10.1093/annonc/mdg448. PMID: 14581278
Selected micronutrients and oral and pharyngeal cancer.
Negri E, Franceschi S, Bosetti C, Levi F, Conti E, Parpinel M, La Vecchia C
Int J Cancer 2000 Apr 1;86(1):122-7. doi: 10.1002/(sici)1097-0215(20000401)86:1<122::aid-ijc19>3.0.co;2-2. PMID: 10728605

Prognosis

CD163 Immunohistochemical "Circle Sign" Staining Pattern Differentiates Sinonasal Papillomas From Morphologically Similar Non-neoplastic Lesions.
Sterling BC, Mehrad M, Ely KA, Lewis JS Jr
Am J Surg Pathol 2022 Nov 1;46(11):1507-1513. Epub 2022 Aug 23 doi: 10.1097/PAS.0000000000001953. PMID: 35993580Free PMC Article
Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy.
Shivappa N, Hébert JR, Rosato V, Garavello W, Serraino D, La Vecchia C
Int J Cancer 2017 Aug 1;141(3):471-479. Epub 2017 May 9 doi: 10.1002/ijc.30711. PMID: 28340515Free PMC Article
AMACR overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma.
Lee YE, He HL, Lee SW, Chen TJ, Chang KY, Hsing CH, Li CF
Tumour Biol 2014 Aug;35(8):7983-91. Epub 2014 May 16 doi: 10.1007/s13277-014-2065-z. PMID: 24833092
Human papilloma virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in Taiwan.
Huang CC, Hsiao JR, Yang MW, Wu YH, Hsu KF, Chang Y, Chen CW, Tsai ST, Wei HP, Jin YT
J Clin Pathol 2011 Jul;64(7):571-7. Epub 2011 Apr 21 doi: 10.1136/jcp.2010.087742. PMID: 21512108
Marital status and cancer risk in Italy.
Randi G, Altieri A, Gallus S, Chatenoud L, Montella M, Franceschi S, Negri E, Talamini R, La Vecchia C
Prev Med 2004 May;38(5):523-8. doi: 10.1016/j.ypmed.2003.12.004. PMID: 15066354

Clinical prediction guides

Diet Quality as Measured by the Healthy Eating Index 2015 and Oral and Pharyngeal Cancer Risk.
Edefonti V, Di Maso M, Tomaino L, Parpinel M, Garavello W, Serraino D, Ferraroni M, Crispo A, La Vecchia C, Bravi F
J Acad Nutr Diet 2022 Sep;122(9):1677-1687.e5. Epub 2021 Jun 11 doi: 10.1016/j.jand.2021.04.020. PMID: 34127426
Histopathology of Sinonasal and Nasopharyngeal Neoplastic Lesions in a Tertiary Care Center of Western Nepal: A Descriptive Cross-sectional Study.
Regmi S, Ghosh A, Gharti Magar D, Thapa S, Koirala KP, Talwar OP
JNMA J Nepal Med Assoc 2021 Jul 30;59(239):657-662. doi: 10.31729/jnma.6859. PMID: 34508496Free PMC Article
Prevalence of Dysphagia in Patients With Non-neoplastic Vocal Fold Pathology.
Hamdan AL, Khalifee E, Jaffal H, Ghanem A, Rizk SA, El Hage A
J Voice 2019 Sep;33(5):708-711. Epub 2018 Jun 5 doi: 10.1016/j.jvoice.2018.05.003. PMID: 29884508
Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy.
Shivappa N, Hébert JR, Rosato V, Garavello W, Serraino D, La Vecchia C
Int J Cancer 2017 Aug 1;141(3):471-479. Epub 2017 May 9 doi: 10.1002/ijc.30711. PMID: 28340515Free PMC Article
Folate intake and risk of oral and pharyngeal cancer.
Pelucchi C, Talamini R, Negri E, Levi F, Conti E, Franceschi S, La Vecchia C
Ann Oncol 2003 Nov;14(11):1677-81. doi: 10.1093/annonc/mdg448. PMID: 14581278

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