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IgE-mediated allergic disorder

MedGen UID:
43785
Concept ID:
C0020523
Pathologic Function
Synonyms: Atopic Hypersensitivities; Atopic Hypersensitivity; Hypersensitivities, Atopic; Hypersensitivities, IgE-Mediated; Hypersensitivities, Immediate; Hypersensitivities, Type I; Hypersensitivity, Atopic; Hypersensitivity, IgE-Mediated; Hypersensitivity, Immediate; Hypersensitivity, Type I; IgE Mediated Hypersensitivity; IgE-Mediated Hypersensitivities; IgE-Mediated Hypersensitivity; Immediate Hypersensitivities; Immediate Hypersensitivity; Type I Hypersensitivities; Type I Hypersensitivity
SNOMED CT: IgE-mediated allergic disorder (422076005); Type I hypersensitivity disorder (422076005); Immediate hypersensitivity disorder (422076005); IgE-mediated hypersensitivity disorder (422076005); Immunoglobulin E-mediated allergic disorder (422076005)
 
OMIM®: 147050

Definition

Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIgE-mediated allergic disorder

Professional guidelines

PubMed

Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Orlandi RR, Kingdom TT, Smith TL, Bleier B, DeConde A, Luong AU, Poetker DM, Soler Z, Welch KC, Wise SK, Adappa N, Alt JA, Anselmo-Lima WT, Bachert C, Baroody FM, Batra PS, Bernal-Sprekelsen M, Beswick D, Bhattacharyya N, Chandra RK, Chang EH, Chiu A, Chowdhury N, Citardi MJ, Cohen NA, Conley DB, DelGaudio J, Desrosiers M, Douglas R, Eloy JA, Fokkens WJ, Gray ST, Gudis DA, Hamilos DL, Han JK, Harvey R, Hellings P, Holbrook EH, Hopkins C, Hwang P, Javer AR, Jiang RS, Kennedy D, Kern R, Laidlaw T, Lal D, Lane A, Lee HM, Lee JT, Levy JM, Lin SY, Lund V, McMains KC, Metson R, Mullol J, Naclerio R, Oakley G, Otori N, Palmer JN, Parikh SR, Passali D, Patel Z, Peters A, Philpott C, Psaltis AJ, Ramakrishnan VR, Ramanathan M Jr, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Sedaghat AR, Senior BA, Sindwani R, Smith K, Snidvongs K, Stewart M, Suh JD, Tan BK, Turner JH, van Drunen CM, Voegels R, Wang Y, Woodworth BA, Wormald PJ, Wright ED, Yan C, Zhang L, Zhou B
Int Forum Allergy Rhinol 2021 Mar;11(3):213-739. doi: 10.1002/alr.22741. PMID: 33236525
Raghu G, Remy-Jardin M, Ryerson CJ, Myers JL, Kreuter M, Vasakova M, Bargagli E, Chung JH, Collins BF, Bendstrup E, Chami HA, Chua AT, Corte TJ, Dalphin JC, Danoff SK, Diaz-Mendoza J, Duggal A, Egashira R, Ewing T, Gulati M, Inoue Y, Jenkins AR, Johannson KA, Johkoh T, Tamae-Kakazu M, Kitaichi M, Knight SL, Koschel D, Lederer DJ, Mageto Y, Maier LA, Matiz C, Morell F, Nicholson AG, Patolia S, Pereira CA, Renzoni EA, Salisbury ML, Selman M, Walsh SLF, Wuyts WA, Wilson KC
Am J Respir Crit Care Med 2020 Aug 1;202(3):e36-e69. doi: 10.1164/rccm.202005-2032ST. PMID: 32706311Free PMC Article

Recent clinical studies

Etiology

Nakata A, Tanaka F, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Kamata N, Taira K, Nagami Y, Watanabe T, Fujiwara Y
J Gastroenterol 2021 May;56(5):422-433. Epub 2021 Feb 16 doi: 10.1007/s00535-021-01766-3. PMID: 33591429
Savilahti EM, Kukkonen AK, Kuitunen M, Savilahti E
Innate Immun 2015 Apr;21(3):332-7. Epub 2014 Nov 27 doi: 10.1177/1753425914541560. PMID: 25432966
Borres MP, Ebisawa M, Eigenmann PA
Pediatr Allergy Immunol 2011 Aug;22(5):454-61. doi: 10.1111/j.1399-3038.2011.01197.x. PMID: 21771081

Diagnosis

Nakata A, Tanaka F, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Kamata N, Taira K, Nagami Y, Watanabe T, Fujiwara Y
J Gastroenterol 2021 May;56(5):422-433. Epub 2021 Feb 16 doi: 10.1007/s00535-021-01766-3. PMID: 33591429
Savilahti EM, Kukkonen AK, Kuitunen M, Savilahti E
Innate Immun 2015 Apr;21(3):332-7. Epub 2014 Nov 27 doi: 10.1177/1753425914541560. PMID: 25432966
Borres MP, Ebisawa M, Eigenmann PA
Pediatr Allergy Immunol 2011 Aug;22(5):454-61. doi: 10.1111/j.1399-3038.2011.01197.x. PMID: 21771081

Therapy

Savilahti EM, Kukkonen AK, Kuitunen M, Savilahti E
Innate Immun 2015 Apr;21(3):332-7. Epub 2014 Nov 27 doi: 10.1177/1753425914541560. PMID: 25432966
Borres MP, Ebisawa M, Eigenmann PA
Pediatr Allergy Immunol 2011 Aug;22(5):454-61. doi: 10.1111/j.1399-3038.2011.01197.x. PMID: 21771081

Prognosis

Savilahti EM, Kukkonen AK, Kuitunen M, Savilahti E
Innate Immun 2015 Apr;21(3):332-7. Epub 2014 Nov 27 doi: 10.1177/1753425914541560. PMID: 25432966
Borres MP, Ebisawa M, Eigenmann PA
Pediatr Allergy Immunol 2011 Aug;22(5):454-61. doi: 10.1111/j.1399-3038.2011.01197.x. PMID: 21771081

Clinical prediction guides

Nakata A, Tanaka F, Nadatani Y, Fukunaga S, Otani K, Hosomi S, Kamata N, Taira K, Nagami Y, Watanabe T, Fujiwara Y
J Gastroenterol 2021 May;56(5):422-433. Epub 2021 Feb 16 doi: 10.1007/s00535-021-01766-3. PMID: 33591429
Borres MP, Ebisawa M, Eigenmann PA
Pediatr Allergy Immunol 2011 Aug;22(5):454-61. doi: 10.1111/j.1399-3038.2011.01197.x. PMID: 21771081

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