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Systemic disease

MedGen UID:
96704
•Concept ID:
C0442893
•
Disease or Syndrome
Synonym: Rare systemic disease
SNOMED CT: Systemic illness (264578000); Systemic disease (56019007)
 
Orphanet: ORPHA182222

Definition

A clinical course finding indicating that a disease presents with systemic manifestations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSystemic disease

Professional guidelines

PubMed

Endometriosis-associated infertility: From pathophysiology to tailored treatment.
Bonavina G, Taylor HS
Front Endocrinol (Lausanne) 2022;13:1020827. Epub 2022 Oct 26 doi: 10.3389/fendo.2022.1020827. PMID: 36387918Free PMC Article
Update οn the diagnosis and management of systemic lupus erythematosus.
Fanouriakis A, Tziolos N, Bertsias G, Boumpas DT
Ann Rheum Dis 2021 Jan;80(1):14-25. Epub 2020 Oct 13 doi: 10.1136/annrheumdis-2020-218272. PMID: 33051219
EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.
Ramos-Casals M, Brito-Zerón P, Bombardieri S, Bootsma H, De Vita S, Dörner T, Fisher BA, Gottenberg JE, Hernandez-Molina G, Kocher A, Kostov B, Kruize AA, Mandl T, Ng WF, Retamozo S, Seror R, Shoenfeld Y, Sisó-Almirall A, Tzioufas AG, Vitali C, Bowman S, Mariette X; EULAR-Sjögren Syndrome Task Force Group
Ann Rheum Dis 2020 Jan;79(1):3-18. Epub 2019 Oct 31 doi: 10.1136/annrheumdis-2019-216114. PMID: 31672775

Recent clinical studies

Etiology

Cutaneous Involvement in Systemic Lupus Erythematosus: A Review for the Rheumatologist.
Stull C, Sprow G, Werth VP
J Rheumatol 2023 Jan;50(1):27-35. Epub 2022 Sep 15 doi: 10.3899/jrheum.220089. PMID: 36109075Free PMC Article
Uveitis for the non-ophthalmologist.
Burkholder BM, Jabs DA
BMJ 2021 Feb 3;372:m4979. doi: 10.1136/bmj.m4979. PMID: 33536186
Cataract and systemic disease: A review.
Ang MJ, Afshari NA
Clin Exp Ophthalmol 2021 Mar;49(2):118-127. Epub 2021 Jan 10 doi: 10.1111/ceo.13892. PMID: 33426783
Association between periodontal pathogens and systemic disease.
Bui FQ, Almeida-da-Silva CLC, Huynh B, Trinh A, Liu J, Woodward J, Asadi H, Ojcius DM
Biomed J 2019 Feb;42(1):27-35. Epub 2019 Mar 2 doi: 10.1016/j.bj.2018.12.001. PMID: 30987702Free PMC Article
Hydroxychloroquine retinopathy.
Yusuf IH, Sharma S, Luqmani R, Downes SM
Eye (Lond) 2017 Jun;31(6):828-845. Epub 2017 Mar 10 doi: 10.1038/eye.2016.298. PMID: 28282061Free PMC Article

Diagnosis

Sjögren syndrome.
Brito-Zerón P, Retamozo S, Ramos-Casals M
Med Clin (Barc) 2023 Feb 24;160(4):163-171. Epub 2022 Dec 15 doi: 10.1016/j.medcli.2022.10.007. PMID: 36528400
Endometriosis is a chronic systemic disease: clinical challenges and novel innovations.
Taylor HS, Kotlyar AM, Flores VA
Lancet 2021 Feb 27;397(10276):839-852. doi: 10.1016/S0140-6736(21)00389-5. PMID: 33640070
Association between periodontal pathogens and systemic disease.
Bui FQ, Almeida-da-Silva CLC, Huynh B, Trinh A, Liu J, Woodward J, Asadi H, Ojcius DM
Biomed J 2019 Feb;42(1):27-35. Epub 2019 Mar 2 doi: 10.1016/j.bj.2018.12.001. PMID: 30987702Free PMC Article
Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review.
Fitzpatrick SG, Cohen DM, Clark AN
Head Neck Pathol 2019 Mar;13(1):91-102. Epub 2019 Mar 7 doi: 10.1007/s12105-018-0981-8. PMID: 30701449Free PMC Article
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article

Therapy

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Current and future therapies for primary Sjögren syndrome.
Seror R, Nocturne G, Mariette X
Nat Rev Rheumatol 2021 Aug;17(8):475-486. Epub 2021 Jun 29 doi: 10.1038/s41584-021-00634-x. PMID: 34188206
Treatment of Sarcoidosis: A Multidisciplinary Approach.
Gerke AK
Front Immunol 2020;11:545413. Epub 2020 Nov 19 doi: 10.3389/fimmu.2020.545413. PMID: 33329511Free PMC Article
Cutaneous lupus erythematosus: diagnosis and treatment.
Okon LG, Werth VP
Best Pract Res Clin Rheumatol 2013 Jun;27(3):391-404. doi: 10.1016/j.berh.2013.07.008. PMID: 24238695Free PMC Article
Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.
Appel GB, Contreras G, Dooley MA, Ginzler EM, Isenberg D, Jayne D, Li LS, Mysler E, Sánchez-Guerrero J, Solomons N, Wofsy D; Aspreva Lupus Management Study Group
J Am Soc Nephrol 2009 May;20(5):1103-12. Epub 2009 Apr 15 doi: 10.1681/ASN.2008101028. PMID: 19369404Free PMC Article

Prognosis

Incidence and prevalence of interstitial lung diseases worldwide: a systematic literature review.
Shah Gupta R, Koteci A, Morgan A, George PM, Quint JK
BMJ Open Respir Res 2023 Jun;10(1) doi: 10.1136/bmjresp-2022-001291. PMID: 37308252Free PMC Article
Epidemiology of rheumatoid arthritis: genetic and environmental influences.
Venetsanopoulou AI, Alamanos Y, Voulgari PV, Drosos AA
Expert Rev Clin Immunol 2022 Sep;18(9):923-931. Epub 2022 Jul 29 doi: 10.1080/1744666X.2022.2106970. PMID: 35904251
Erythema Nodosum: A Practical Approach and Diagnostic Algorithm.
Pérez-Garza DM, Chavez-Alvarez S, Ocampo-Candiani J, Gomez-Flores M
Am J Clin Dermatol 2021 May;22(3):367-378. Epub 2021 Mar 8 doi: 10.1007/s40257-021-00592-w. PMID: 33683567Free PMC Article
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
Hydroxychloroquine retinopathy.
Yusuf IH, Sharma S, Luqmani R, Downes SM
Eye (Lond) 2017 Jun;31(6):828-845. Epub 2017 Mar 10 doi: 10.1038/eye.2016.298. PMID: 28282061Free PMC Article

Clinical prediction guides

Effect of Intraoperative Esketamine Infusion on Postoperative Sleep Disturbance After Gynecological Laparoscopy: A Randomized Clinical Trial.
Qiu D, Wang XM, Yang JJ, Chen S, Yue CB, Hashimoto K, Yang JJ
JAMA Netw Open 2022 Dec 1;5(12):e2244514. doi: 10.1001/jamanetworkopen.2022.44514. PMID: 36454569Free PMC Article
Interventions for managing halitosis.
Kumbargere Nagraj S, Eachempati P, Uma E, Singh VP, Ismail NM, Varghese E
Cochrane Database Syst Rev 2019 Dec 11;12(12):CD012213. doi: 10.1002/14651858.CD012213.pub2. PMID: 31825092Free PMC Article
Pathophysiology, Diagnosis, and Management of Chronic Intestinal Pseudo-Obstruction.
Downes TJ, Cheruvu MS, Karunaratne TB, De Giorgio R, Farmer AD
J Clin Gastroenterol 2018 Jul;52(6):477-489. doi: 10.1097/MCG.0000000000001047. PMID: 29877952
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Breast cancer metastasis: markers and models.
Weigelt B, Peterse JL, van 't Veer LJ
Nat Rev Cancer 2005 Aug;5(8):591-602. doi: 10.1038/nrc1670. PMID: 16056258

Recent systematic reviews

Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis.
Alkodaymi MS, Omrani OA, Fawzy NA, Shaar BA, Almamlouk R, Riaz M, Obeidat M, Obeidat Y, Gerberi D, Taha RM, Kashour Z, Kashour T, Berbari EF, Alkattan K, Tleyjeh IM
Clin Microbiol Infect 2022 May;28(5):657-666. Epub 2022 Feb 3 doi: 10.1016/j.cmi.2022.01.014. PMID: 35124265Free PMC Article
Systematic review on diabetes mellitus and dental implants: an update.
Wagner J, Spille JH, Wiltfang J, Naujokat H
Int J Implant Dent 2022 Jan 3;8(1):1. doi: 10.1186/s40729-021-00399-8. PMID: 34978649Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Effectiveness of Conservative Treatment According to Severity and Systemic Disease in Carpal Tunnel Syndrome: A Systematic Review.
Hernández-Secorún M, Montaña-Cortés R, Hidalgo-García C, Rodríguez-Sanz J, Corral-de-Toro J, Monti-Ballano S, Hamam-Alcober S, Tricás-Moreno JM, Lucha-López MO
Int J Environ Res Public Health 2021 Feb 28;18(5) doi: 10.3390/ijerph18052365. PMID: 33671060Free PMC Article
Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis.
Fritz D, van de Beek D, Brouwer MC
BMC Neurol 2016 Nov 15;16(1):220. doi: 10.1186/s12883-016-0741-x. PMID: 27846819Free PMC Article

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