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Myoepithelial tumor

MedGen UID:
10235
•Concept ID:
C0027070
•
Neoplastic Process
Synonyms: Myoepithelial Tumor; Myoepithelial Tumors; Myoepithelioma; Myoepitheliomas; Tumor, Myoepithelial; Tumors, Myoepithelial
SNOMED CT: Myoepithelioma (69291002); Myoepithelial tumor (69291002); Myoepithelial adenoma (69291002)
 
Monarch Initiative: MONDO:0002380

Definition

A benign or malignant tumor characterized by the presence of cells that show myoepithelial differentiation. Based on its morphologic features, it is classified as benign or malignant. A representative example of benign myoepithelioma is benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma or myoepithelial carcinoma are malignant breast myoepithelioma and salivary gland myoepithelial carcinoma. [from NCI]

Professional guidelines

PubMed

PLACE AND TECHNICS OF RADIATION THERAPY IN THE MANAGEMENT OF MALIGNANT TUMORS OF THE MAJOR SALIVARY GLANDS.
ALANIZ F, FLETCHER GH
Radiology 1965 Mar;84:412-9. doi: 10.1148/84.3.412. PMID: 14280711
SALIVARY GLAND TUMORS. THEIR EARLY DIAGNOSIS AND TREATMENT.
NELSON WR, DAVIS WM
Rocky Mt Med J 1964 May;61:27-32. PMID: 14153101
THE MANAGEMENT AND PROGNOSIS OF METASTATIC NEOPLASMS OF THE NECK WITH AN UNKNOWN PRIMARY.
FRANCE CJ, LUCAS R
Am J Surg 1963 Nov;106:835-9. doi: 10.1016/0002-9610(63)90411-2. PMID: 14078740

Recent clinical studies

Etiology

Myoepithelial and oral intracranial myxoid mesenchymal tumor-like neoplasms as diagnostic considerations of the ever-expanding extracranial myxocollagenous tumors harboring FET-CREB fusions.
Lee PH, Kao YC, Hsieh TH, Liao JB, Li CF, Lee JC, Chang YM, Chang CD, Huang SC, Chen TJ, Liu TT, Yu SC, Huang HY
Pathol Res Pract 2022 Jan;229:153700. Epub 2021 Nov 24 doi: 10.1016/j.prp.2021.153700. PMID: 34929603
Uncommon and peculiar soft tissue sarcomas: Multidisciplinary review and practical recommendations. Spanish Group for Sarcoma research (GEIS -GROUP). Part II.
Martínez-Trufero J, Cruz Jurado J, Hernández-León CN, Correa R, Asencio JM, Bernabeu D, Alvarez R, Hindi N, Mata C, Marquina G, Martínez V, Redondo A, Floría LJ, Gómez-Mateo MC, Lavernia J, Sebio A, Garcia Del Muro X, Martin-Broto J, Valverde-Morales C
Cancer Treat Rev 2021 Sep;99:102260. Epub 2021 Jul 16 doi: 10.1016/j.ctrv.2021.102260. PMID: 34340159
Pulmonary Myoepithelial Tumors With Exuberant Reactive Pneumocytes: Proposed Reclassification of So-called Pneumocytic Adenomyoepithelioma.
Yuan L, Katabi N, Antonescu CR, Golden A, Travis WD, Rekhtman N
Am J Surg Pathol 2020 Jan;44(1):140-147. doi: 10.1097/PAS.0000000000001376. PMID: 31567188Free PMC Article
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310

Diagnosis

Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Myoepithelial tumor of soft tissue and bone: A current perspective.
Verma A, Rekhi B
Histol Histopathol 2017 Sep;32(9):861-877. Epub 2017 Feb 1 doi: 10.14670/HH-11-879. PMID: 28145559
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310
Bronchial epithelial-myoepithelial carcinoma.
Chao TY, Lin AS, Lie CH, Chung YH, Lin JW, Lin MC
Ann Thorac Surg 2007 Feb;83(2):689-91. doi: 10.1016/j.athoracsur.2006.07.025. PMID: 17258020
Bronchial epithelial-myoepithelial carcinoma.
Ru K, Srivastava A, Tischler AS
Arch Pathol Lab Med 2004 Jan;128(1):92-4. doi: 10.5858/2004-128-92-BEC. PMID: 14692803

Therapy

An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion.
Haglund C, Zemmler M, Tsagkozis P, Haglund de Flon F
Genes Chromosomes Cancer 2023 Oct;62(10):607-610. Epub 2023 May 2 doi: 10.1002/gcc.23148. PMID: 37129228
Anti-androgen for myoepithelial tumor: a potent therapy yet a potential misleader.
Hijab A, Taha T, Charas T, Bar-Sela G, Stein P, Agbarya A
Anticancer Drugs 2022 Jan 1;33(1):e747-e751. doi: 10.1097/CAD.0000000000001175. PMID: 34387605
Bone Sarcoma With EWSR1-NFATC2 Fusion: Sarcoma With Varied Morphology and Amplification of Fusion Gene Distinct From Ewing Sarcoma.
Yau DTW, Chan JKC, Bao S, Zheng Z, Lau GTC, Chan ACL
Int J Surg Pathol 2019 Aug;27(5):561-567. Epub 2019 Feb 3 doi: 10.1177/1066896919827093. PMID: 30714449
Non-rhabdoid pediatric SMARCB1-deficient tumors: overlap between chordomas and malignant rhabdoid tumors?
Renard C, Pissaloux D, Decouvelaere AV, Bourdeaut F, Ranchère D
Cancer Genet 2014 Sep;207(9):384-9. Epub 2014 May 23 doi: 10.1016/j.cancergen.2014.05.005. PMID: 25053104

Prognosis

Myoepithelial Tumors of Salivary Gland: A Clinicopathologic and Immunohistochemical Study of 15 Patients with MIB-1 Correlation.
Telugu RB, Gaikwad P, Baitule A, Michael RC, Mani T, Thomas M
Head Neck Pathol 2021 Jun;15(2):479-490. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01225-0. PMID: 32959208Free PMC Article
Pigmented (melanotic) myoepithelial tumor of soft tissue with EWSR1-KLF17 fusion.
Pižem J, Boštjančič E, Šekoranja D, Pleško J, Živec K
Cancer Genet 2020 Aug;246-247:48-52. Epub 2020 Aug 12 doi: 10.1016/j.cancergen.2020.08.001. PMID: 32829130
Newly Described Entities in Salivary Gland Pathology.
Skálová A, Gnepp DR, Lewis JS Jr, Hunt JL, Bishop JA, Hellquist H, Rinaldo A, Vander Poorten V, Ferlito A
Am J Surg Pathol 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883. PMID: 28614209
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310
Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature.
Pelosi G, Fraggetta F, Maffini F, Solli P, Cavallon A, Viale G
Mod Pathol 2001 May;14(5):521-6. doi: 10.1038/modpathol.3880341. PMID: 11353064

Clinical prediction guides

GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics.
Toland AMS, Lam SW, Varma S, Wang A, Howitt BE, Kunder CA, Kerr DA, Szuhai K, Bovée JVMG, Charville GW
Am J Surg Pathol 2022 Oct 1;46(10):1407-1414. Epub 2022 Jun 1 doi: 10.1097/PAS.0000000000001921. PMID: 35650682Free PMC Article
Myoepithelial and oral intracranial myxoid mesenchymal tumor-like neoplasms as diagnostic considerations of the ever-expanding extracranial myxocollagenous tumors harboring FET-CREB fusions.
Lee PH, Kao YC, Hsieh TH, Liao JB, Li CF, Lee JC, Chang YM, Chang CD, Huang SC, Chen TJ, Liu TT, Yu SC, Huang HY
Pathol Res Pract 2022 Jan;229:153700. Epub 2021 Nov 24 doi: 10.1016/j.prp.2021.153700. PMID: 34929603
Myoepithelial tumor of soft tissue: histology and genetics of an evolving entity.
Thway K, Fisher C
Adv Anat Pathol 2014 Nov;21(6):411-9. doi: 10.1097/PAP.0000000000000039. PMID: 25299310
Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature.
Pelosi G, Fraggetta F, Maffini F, Solli P, Cavallon A, Viale G
Mod Pathol 2001 May;14(5):521-6. doi: 10.1038/modpathol.3880341. PMID: 11353064
Large, central acellular zones indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases.
Tsuda H, Takarabe T, Hasegawa F, Fukutomi T, Hirohashi S
Am J Surg Pathol 2000 Feb;24(2):197-202. doi: 10.1097/00000478-200002000-00005. PMID: 10680887

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