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Therapy-Related Neoplasm

MedGen UID:
88608
•Concept ID:
C0086696
•
Neoplastic Process
Synonyms: Neoplasm, Therapy-Associated; Neoplasm, Therapy-Related; Neoplasm, Treatment-Associated; Neoplasm, Treatment-Related; Neoplasms, Therapy Associated; Neoplasms, Therapy Related; Neoplasms, Therapy-Associated; Neoplasms, Therapy-Related; Neoplasms, Treatment Associated; Neoplasms, Treatment Related; Neoplasms, Treatment-Associated; Neoplasms, Treatment-Related; Therapy Associated Neoplasms; Therapy Related Neoplasms; Therapy-Associated Neoplasm; Therapy-Associated Neoplasms; Therapy-Related Neoplasms; Treatment Associated Neoplasms; Treatment Related Neoplasms; Treatment-Associated Neoplasm; Treatment-Associated Neoplasms; Treatment-Related Neoplasm; Treatment-Related Neoplasms

Definition

The development of a neoplasm in response to medical or surgical treatment, induced by the treatment itself. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTherapy-Related Neoplasm

Professional guidelines

PubMed

Second primary malignancies in patients with haematological cancers treated with lenalidomide: a systematic review and meta-analysis.
Saleem K, Franz J, Klem ML, Yabes JG, Boyiadzis M, Jones JR, Shaikh N, Lontos K
Lancet Haematol 2022 Dec;9(12):e906-e918. Epub 2022 Oct 27 doi: 10.1016/S2352-3026(22)00289-7. PMID: 36354020

Recent clinical studies

Etiology

Therapy-related chronic myelomonocytic leukemia does not have the high-risk features of a therapy-related neoplasm.
Bataller A, Gener-Ricos G, Almanza-Huante E, Chien KS, Urrutia S, Bazinet A, Rodriguez-Sevilla JJ, Hammond D, Sasaki K, Takahashi K, DiNardo CD, Ravandi F, Borthakur G, Kadia TM, Kanagal-Shamanna R, Kantarjian HM, Garcia-Manero G, Montalban-Bravo G
Blood Adv 2024 Jun 11;8(11):2695-2706. doi: 10.1182/bloodadvances.2024012565. PMID: 38513082
Second primary malignancies in patients with haematological cancers treated with lenalidomide: a systematic review and meta-analysis.
Saleem K, Franz J, Klem ML, Yabes JG, Boyiadzis M, Jones JR, Shaikh N, Lontos K
Lancet Haematol 2022 Dec;9(12):e906-e918. Epub 2022 Oct 27 doi: 10.1016/S2352-3026(22)00289-7. PMID: 36354020
A 14-year retrospective analysis of indications and outcomes of autologous haemopoietic stem cell transplantation in regional Queensland: a single-centre experience.
Hamilton EM, Nath KD, Vangaveti VN, McCutchan AD, Marsh JL, Birchley AJ, Casey JM, McNamara C, Lai HC, Morris ES, Hodges G, Irving IM
Intern Med J 2020 Feb;50(2):214-221. doi: 10.1111/imj.14395. PMID: 32037713
t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
Xie W, Tang G, Wang E, Kim Y, Cloe A, Shen Q, Zhou Y, Garcia-Manero G, Loghavi S, Hu AY, Wang S, Bueso-Ramos CE, Kantarjian HM, Medeiros LJ, Hu S
Ann Hematol 2020 Mar;99(3):487-500. Epub 2020 Jan 31 doi: 10.1007/s00277-020-03909-7. PMID: 32006151

Diagnosis

Therapy-related chronic myelomonocytic leukemia does not have the high-risk features of a therapy-related neoplasm.
Bataller A, Gener-Ricos G, Almanza-Huante E, Chien KS, Urrutia S, Bazinet A, Rodriguez-Sevilla JJ, Hammond D, Sasaki K, Takahashi K, DiNardo CD, Ravandi F, Borthakur G, Kadia TM, Kanagal-Shamanna R, Kantarjian HM, Garcia-Manero G, Montalban-Bravo G
Blood Adv 2024 Jun 11;8(11):2695-2706. doi: 10.1182/bloodadvances.2024012565. PMID: 38513082
Therapy-related acute megakaryoblastic leukemia with severe myelofibrosis.
Yoshino H, Gemma Y, Miyazawa N, Bessho F, Yan K
Pediatr Int 2022 Jan;64(1):e14842. doi: 10.1111/ped.14842. PMID: 35103363
t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
Xie W, Tang G, Wang E, Kim Y, Cloe A, Shen Q, Zhou Y, Garcia-Manero G, Loghavi S, Hu AY, Wang S, Bueso-Ramos CE, Kantarjian HM, Medeiros LJ, Hu S
Ann Hematol 2020 Mar;99(3):487-500. Epub 2020 Jan 31 doi: 10.1007/s00277-020-03909-7. PMID: 32006151

Therapy

Second primary malignancies in patients with haematological cancers treated with lenalidomide: a systematic review and meta-analysis.
Saleem K, Franz J, Klem ML, Yabes JG, Boyiadzis M, Jones JR, Shaikh N, Lontos K
Lancet Haematol 2022 Dec;9(12):e906-e918. Epub 2022 Oct 27 doi: 10.1016/S2352-3026(22)00289-7. PMID: 36354020
t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
Xie W, Tang G, Wang E, Kim Y, Cloe A, Shen Q, Zhou Y, Garcia-Manero G, Loghavi S, Hu AY, Wang S, Bueso-Ramos CE, Kantarjian HM, Medeiros LJ, Hu S
Ann Hematol 2020 Mar;99(3):487-500. Epub 2020 Jan 31 doi: 10.1007/s00277-020-03909-7. PMID: 32006151

Clinical prediction guides

Therapy-related chronic myelomonocytic leukemia does not have the high-risk features of a therapy-related neoplasm.
Bataller A, Gener-Ricos G, Almanza-Huante E, Chien KS, Urrutia S, Bazinet A, Rodriguez-Sevilla JJ, Hammond D, Sasaki K, Takahashi K, DiNardo CD, Ravandi F, Borthakur G, Kadia TM, Kanagal-Shamanna R, Kantarjian HM, Garcia-Manero G, Montalban-Bravo G
Blood Adv 2024 Jun 11;8(11):2695-2706. doi: 10.1182/bloodadvances.2024012565. PMID: 38513082
A 14-year retrospective analysis of indications and outcomes of autologous haemopoietic stem cell transplantation in regional Queensland: a single-centre experience.
Hamilton EM, Nath KD, Vangaveti VN, McCutchan AD, Marsh JL, Birchley AJ, Casey JM, McNamara C, Lai HC, Morris ES, Hodges G, Irving IM
Intern Med J 2020 Feb;50(2):214-221. doi: 10.1111/imj.14395. PMID: 32037713
t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
Xie W, Tang G, Wang E, Kim Y, Cloe A, Shen Q, Zhou Y, Garcia-Manero G, Loghavi S, Hu AY, Wang S, Bueso-Ramos CE, Kantarjian HM, Medeiros LJ, Hu S
Ann Hematol 2020 Mar;99(3):487-500. Epub 2020 Jan 31 doi: 10.1007/s00277-020-03909-7. PMID: 32006151

Recent systematic reviews

Second primary malignancies in patients with haematological cancers treated with lenalidomide: a systematic review and meta-analysis.
Saleem K, Franz J, Klem ML, Yabes JG, Boyiadzis M, Jones JR, Shaikh N, Lontos K
Lancet Haematol 2022 Dec;9(12):e906-e918. Epub 2022 Oct 27 doi: 10.1016/S2352-3026(22)00289-7. PMID: 36354020

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