U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vaginal squamous tumor

MedGen UID:
274381
•Concept ID:
C1519931
•
Neoplastic Process
Synonyms: vagina squamous cell neoplasm; Vaginal Squamous Neoplasm; vaginal squamous neoplasm; Vaginal Squamous Tumor; vaginal squamous tumor
 
Monarch Initiative: MONDO:0001806

Definition

A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vagina. [from NCI]

Professional guidelines

PubMed

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Cervical Colposcopy: Indications and Risk Assessment.
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071

Recent clinical studies

Etiology

Prolapsing vaginal fibroepithelial polyp.
Leffelman A, Valaitis S
BMJ Case Rep 2022 Dec 22;15(12) doi: 10.1136/bcr-2022-250967. PMID: 36549754Free PMC Article
Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort.
Chen Y, Qiu X, Wang W, Li D, Wu A, Hong Z, Di W, Qiu L
BMC Infect Dis 2020 Aug 26;20(1):629. doi: 10.1186/s12879-020-05324-9. PMID: 32842982Free PMC Article
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Cervical cancer.
Shepherd JH
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):293-309. Epub 2012 Feb 19 doi: 10.1016/j.bpobgyn.2011.12.004. PMID: 22353492

Diagnosis

Squamous and Glandular Lesions of the Vulva and Vagina: What's New and What Remains Unanswered?
Wei KX, Hoang LN
Surg Pathol Clin 2022 Jun;15(2):389-405. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.011. PMID: 35715167
Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Genital diseases in the mature woman.
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Human Papillomavirus Laboratory Testing: the Changing Paradigm.
Burd EM
Clin Microbiol Rev 2016 Apr;29(2):291-319. doi: 10.1128/CMR.00013-15. PMID: 26912568Free PMC Article
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Therapy

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.
How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A
Sci Rep 2021 Feb 11;11(1):3667. doi: 10.1038/s41598-021-83317-7. PMID: 33574401Free PMC Article
Management and outcomes of primary vaginal Cancer.
Yang J, Delara R, Magrina J, Magtibay P, Langstraat C, Dinh T, Karlin N, Vora SA, Butler K
Gynecol Oncol 2020 Nov;159(2):456-463. Epub 2020 Sep 22 doi: 10.1016/j.ygyno.2020.08.036. PMID: 32972784
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article

Prognosis

Genital diseases in the mature woman.
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Management of Early Stage Cervical Cancer.
Somashekhar SP, Ashwin KR
Rev Recent Clin Trials 2015;10(4):302-8. doi: 10.2174/1574887110666150923113629. PMID: 26411950
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Primary carcinoma of the vagina.
Lilic V, Lilic G, Filipovic S, Visnjic M, Zivadinovic R
J BUON 2010 Apr-Jun;15(2):241-7. PMID: 20658716

Clinical prediction guides

Vaginal Microbiome Dysbiosis is Associated with the Different Cervical Disease Status.
Ma Y, Li Y, Liu Y, Cao L, Han X, Gao S, Zhang C
J Microbiol 2023 Apr;61(4):423-432. Epub 2023 Apr 3 doi: 10.1007/s12275-023-00039-3. PMID: 37010797
Microbiota unbalance in relation to high-risk human papillomavirus cervical infection.
Gomez Cherey JF, Payalef SN, Fleider L, Reyes AP, Maldonado VA, Losada MO, Chen X, Cardinal LH, Wang Y, Tatti SA, Perazzi BE
Int J Gynecol Cancer 2023 Apr 3;33(4):482-488. doi: 10.1136/ijgc-2022-003760. PMID: 36604120
Clinical and morphopathological assay in vulvovaginal candidiasis.
Manolea MM, Istrate-Ofiţeru AM, Săndulescu MS, Camen IV, Piciu IA, Dijmărescu AL, Vrabie SC, Neamţu SD, Obleagă CV, Siminel MA
Rom J Morphol Embryol 2022 Jul-Sep;63(3):511-520. doi: 10.47162/RJME.63.3.05. PMID: 36588489Free PMC Article
Comparative measurement of D- and L-lactic acid isomers in vaginal secretions: association with high-grade cervical squamous intraepithelial lesions.
de Magalhães CCB, Linhares IM, Masullo LF, Eleutério RMN, Witkin SS, Eleutério J Jr
Arch Gynecol Obstet 2022 Feb;305(2):373-377. Epub 2021 Sep 23 doi: 10.1007/s00404-021-06258-6. PMID: 34554315
Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.
How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A
Sci Rep 2021 Feb 11;11(1):3667. doi: 10.1038/s41598-021-83317-7. PMID: 33574401Free PMC Article

Recent systematic reviews

Efficacy of photodynamic therapy in women with HSIL, LSIL and early stage squamous cervical cancer: a systematic review and meta-analysis.
Unanyan A, Pivazyan L, Davydova J, Murvatova K, Khrapkova A, Movsisyan R, Ishchenko A, Ishchenko A
Photodiagnosis Photodyn Ther 2021 Dec;36:102530. Epub 2021 Sep 14 doi: 10.1016/j.pdpdt.2021.102530. PMID: 34534688
Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina.
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article
Atypical glandular cells and cervical cancer: systematic review.
Marques JP, Costa LB, Pinto AP, Lima AF, Duarte ME, Barbosa AP, Medeiros PL
Rev Assoc Med Bras (1992) 2011 Mar-Apr;57(2):234-8. doi: 10.1590/s0104-42302011000200024. PMID: 21537713

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...