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Non-Neoplastic Thyroid Gland Disorder

MedGen UID:: 277431
•Concept ID:: C1335047
•: Disease or Syndrome

Definition

A non-neoplastic disorder that affects the thyroid gland. Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, and thyroid gland abscess. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNon-Neoplastic Thyroid Gland Disorder

Pathological process
- Disease
  - Disorder by Site
    - Head and Neck Disorder
      - Disorder of neck
        Non-Neoplastic Neck Disorder
        Non-Neoplastic Thyroid Gland Disorder
        Abscess of thyroid
        Atrophy of thyroid
        Congenital Thyroid Gland Disorder
        Congenital hypothyroidism
        Congenital hypothyroidism with ectopic thyroid
        Congenital iodine deficiency syndrome
        Deficiency of iodide peroxidase
        Dual Oxidase 2 Deficiency
        Genetic transient congenital hypothyroidism
        Hypothyroidism due to iodide transport defect
        Hypothyroidism due to TSH receptor mutations
        Hypothyroidism, congenital, nongoitrous, 2
        Iodotyrosine deiodination defect
        Isolated thyroid-stimulating hormone deficiency
        Pendred syndrome
        Thyroglobulin Deficiency
        Thyroid dyshormonogenesis
        Thyroid dyshormonogenesis 6
        Congenital thyroid hypoplasia
        Ectopic thyroid
        Accessory ectopic thyroid tissue
        Lingual thyroid
        Thyroid agenesis
        Diffuse C-Cell Hyperplasia
        Goiter
        Congenital goiter
        Diffuse goiter
        Endemic goiter
        Euthyroid goiter
        Euthyroid multinodular goiter
        Graves disease
        Neonatal Graves disease
        Thyroid eye disease
        Hypothyroid Goiter
        Lingual goiter
        Nodular goiter
        Multinodular goiter
        Uninodular goiter
        Nontoxic goiter
        Non-toxic nodular goiter
        Plummer disease
        Substernal goiter
        Hyperthyroidism
        Acquired Hyperthyroidism
        Central Hyperthyroidism
        Congenital Hyperthyroidism
        Hyperthyroxinemia, familial dysalbuminemic
        Iodine-induced hyperthyroidism
        Primary Hyperthyroidism
        Transient Primary Hypothyroidism
        Thyroid crisis
        Thyrotoxicosis
        Hyperthyroidism with Hashimoto disease
        Neonatal thyrotoxicosis
        Thyrotoxicosis from ectopic thyroid tissue
        Thyrotoxicosis with diffuse goiter
        Thyrotoxicosis with toxic multinodular goiter
        Thyrotoxicosis with toxic single thyroid nodule
        Hypothyroidism
        Acquired hypothyroidism
        Central hypothyroidism
        Acquired central hypothyroidism
        Hypothalamic hypothyroidism
        Iatrogenic Central Hypothyroidism
        Pituitary hypothyroidism
        Compensated hypothyroidism
        Iodine Deficiency Hypothyroidism
        Myxedema
        Primary hypothyroidism
        Iatrogenic Primary Hypothyroidism
        Transient hypothyroxinemia
        Wolff-Chaikoff Phenomenon
        Reactive C-Cell Hyperplasia
        Thyroid dysgenesis
        Thyroid Gland Rosai-Dorfman Disease
        Thyroid hormone resistance syndrome
        Generalized resistance to thyroid hormone
        Thyroiditis
        Autoimmune thyroid disease
        Hashimoto thyroiditis
        Postpartum thyroiditis
        Subacute lymphocytic thyroiditis
        IgG4-related thyroid disease
        Subacute thyroiditis
        Suppurative thyroiditis
        Transient congenital hypothyroidism

Professional guidelines

PubMed

TROP-2 immunohistochemistry: a highly accurate method in the differential diagnosis of papillary thyroid carcinoma.

Bychkov A, Sampatanukul P, Shuangshoti S, Keelawat S
Pathology 2016 Aug;48(5):425-33. Epub 2016 Jun 14 doi: 10.1016/j.pathol.2016.04.002. PMID: 27311870

Immunohistochemical expression of HBME-1 and galectin-3 in the differential diagnosis of follicular-derived thyroid nodules.

Abd-El Raouf SM, Ibrahim TR
Pathol Res Pract 2014 Dec;210(12):971-8. Epub 2014 Jun 27 doi: 10.1016/j.prp.2014.06.010. PMID: 25041837

Transsphenoidal treatment of non-neoplastic intrasellar cysts. A report of 38 cases.

Baskin DS, Wilson CB
J Neurosurg 1984 Jan;60(1):8-13. doi: 10.3171/jns.1984.60.1.0008. PMID: 6689730

See all (9)

Recent clinical studies

Etiology

INFLUENCE OF IONIZING RADIATION ON THE DEVELOPMENT OF BREAST CANCER.

Bazyka DA, Lytvynenko OO, Litvinenko OO
Probl Radiac Med Radiobiol 2023 Dec;28:22-48. doi: 10.33145/2304-8336-2023-28-22-48. PMID: 38155113

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.

Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235

Follicular Growth Pattern Disease on Thyroid Fine-needle Aspiration Biopsy.

Tastekin E, Canberk S, Schmitt FC
Balkan Med J 2022 Jul 22;39(4):230-238. Epub 2022 Jun 20 doi: 10.4274/balkanmedj.galenos.2022.2022-5-17. PMID: 35719013 Free PMC Article

Histopathological Spectrum of Non-Neoplastic and Neoplastic Lesions of Thyroid: A Descriptive Cross-sectional Study.

Ghartimagar D, Ghosh A, Shrestha MK, Thapa S, Talwar OP
JNMA J Nepal Med Assoc 2020 Nov 22;58(231):856-861. doi: 10.31729/jnma.5038. PMID: 34506431 Free PMC Article

Factors influencing thyroidectomy complications.

Ernandes-Neto M, Tagliarini JV, López BE, Padovani CR, Marques Mde A, Castilho EC, Mazeto GM
Braz J Otorhinolaryngol 2012 Jun;78(3):63-9. doi: 10.1590/S1808-86942012000300012. PMID: 22714849 Free PMC Article

See all (109)

Diagnosis

Pediatric orbital lesions: non-neoplastic extraocular soft-tissue lesions.

Gerrie SK, Rajani H, Navarro OM, Lyons CJ, Marie E, Frayn CS, Hughes ECM, Branson HM
Pediatr Radiol 2024 May;54(6):910-921. Epub 2024 Feb 28 doi: 10.1007/s00247-024-05892-x. PMID: 38413469

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.

Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235

Challenges in Cytology Specimens With Hürthle Cells.

Thodou E, Canberk S, Schmitt F
Front Endocrinol (Lausanne) 2021;12:701877. Epub 2021 Jun 25 doi: 10.3389/fendo.2021.701877. PMID: 34248855 Free PMC Article

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

Endocrine and neuroendocrine cytopathology.

Bongiovanni M, La Rosa S, Sykiotis GP
Minerva Endocrinol 2018 Sep;43(3):294-304. Epub 2017 Sep 25 doi: 10.23736/S0391-1977.17.02744-4. PMID: 28949123

See all (154)

Therapy

Post-thyroidectomy complications in southwestern Saudi Arabia: a retrospective study of a 6-year period.

Bawa D, Alghamdi A, Albishi H, Al-Tufail N, Sharma SP, Khalifa YM, Khan S, Alhajmohammed MA
Ann Saudi Med 2021 Nov-Dec;41(6):369-375. Epub 2021 Dec 2 doi: 10.5144/0256-4947.2021.369. PMID: 34873936 Free PMC Article

GADD45B Transcript Is a Prognostic Marker in Papillary Thyroid Carcinoma Patients Treated With Total Thyroidectomy and Radioiodine Therapy.

Barros-Filho MC, de Mello JBH, Marchi FA, Pinto CAL, da Silva IC, Damasceno PKF, Soares MBP, Kowalski LP, Rogatto SR
Front Endocrinol (Lausanne) 2020;11:269. Epub 2020 Apr 30 doi: 10.3389/fendo.2020.00269. PMID: 32425887 Free PMC Article

Factors influencing thyroidectomy complications.

Incretin receptors in non-neoplastic and neoplastic thyroid C cells in rodents and humans: relevance for incretin-based diabetes therapy.

Waser B, Beetschen K, Pellegata NS, Reubi JC
Neuroendocrinology 2011;94(4):291-301. Epub 2011 Sep 2 doi: 10.1159/000330447. PMID: 21893952

Inappropriate secretion of thyroid-stimulating hormone.

Ann Intern Med 1981 Sep;95(3):339-51. doi: 10.7326/0003-4819-95-3-339. PMID: 7023312

See all (22)

Prognosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.

Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

Undifferentiated (anaplastic) thyroid carcinoma: Practical immunohistochemistry and cytologic look-alikes.

Talbott I, Wakely PE Jr
Semin Diagn Pathol 2015 Jul;32(4):305-10. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.012. PMID: 25596874

Telomerase promoter mutations in cancer: an emerging molecular biomarker?

Vinagre J, Pinto V, Celestino R, Reis M, Pópulo H, Boaventura P, Melo M, Catarino T, Lima J, Lopes JM, Máximo V, Sobrinho-Simões M, Soares P
Virchows Arch 2014 Aug;465(2):119-33. Epub 2014 Jul 22 doi: 10.1007/s00428-014-1608-4. PMID: 25048572

Oncocytic lesions of the neuroendocrine system.

Canberk S, LiVolsi VA, Baloch Z
Adv Anat Pathol 2014 Mar;21(2):69-82. doi: 10.1097/PAP.0000000000000011. PMID: 24508690

See all (71)

Clinical prediction guides

TROP2: a potential marker in diagnosis of thyroid neoplasms.

Turan Z, Erkılıç S
Ir J Med Sci 2023 Feb;192(1):99-103. Epub 2022 Mar 30 doi: 10.1007/s11845-022-02976-1. PMID: 35355197

Hashimoto's thyroiditis in papillary thyroid carcinoma: a 22-year study.

Hanege FM, Tuysuz O, Celik S, Sakallıoglu O, Arslan Solmaz O
Acta Otorhinolaryngol Ital 2021 Apr;41(2):142-145. doi: 10.14639/0392-100X-N1081. PMID: 34028458 Free PMC Article

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

Undifferentiated (anaplastic) thyroid carcinoma: Practical immunohistochemistry and cytologic look-alikes.

Talbott I, Wakely PE Jr
Semin Diagn Pathol 2015 Jul;32(4):305-10. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.012. PMID: 25596874

Education and cancer risk.

La Vecchia C, Negri E, Franceschi S
Cancer 1992 Dec 15;70(12):2935-41. doi: 10.1002/1097-0142(19921215)70:12<2935::aid-cncr2820701234>3.0.co;2-3. PMID: 1451077

See all (92)

Recent systematic reviews

False positive cases in thyroid cytopathology - the experience of a single laboratory and a systematic review.

Mezei T, Kolcsár M, Pașcanu I, Vielh P
Cytopathology 2021 Jul;32(4):493-504. Epub 2021 Apr 29 doi: 10.1111/cyt.12984. PMID: 33914381

High risk of malignancy in cases with atypia of undetermined significance on fine needle aspiration of thyroid nodules even after exclusion of NIFTP.

Özkara SK, Bayrak BY, Turan G
Diagn Cytopathol 2020 Nov;48(11):986-997. Epub 2020 Aug 3 doi: 10.1002/dc.24533. PMID: 32745375

Defining the value of CD56, CK19, Galectin 3 and HBME-1 in diagnosis of follicular cell derived lesions of thyroid with systematic review of literature.

Dunđerović D, Lipkovski JM, Boričic I, Soldatović I, Božic V, Cvejić D, Tatić S
Diagn Pathol 2015 Oct 26;10:196. doi: 10.1186/s13000-015-0428-4. PMID: 26503236 Free PMC Article

See all (3)

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Non-Neoplastic Thyroid Gland Disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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