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Non-Small Cell Carcinoma

MedGen UID:
220404
•Concept ID:
C1266002
•
Neoplastic Process
Synonym: Non-small cell carcinoma
SNOMED CT: Non-small cell carcinoma (128632008)

Definition

A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Small Cell Carcinoma

Professional guidelines

PubMed

Radiotherapy treatment for lung cancer: Current status and future directions.
Vinod SK, Hau E
Respirology 2020 Nov;25 Suppl 2:61-71. Epub 2020 Jun 9 doi: 10.1111/resp.13870. PMID: 32516852
Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Pulmonary squamous cell carcinoma and lymphoepithelial carcinoma - morphology, molecular characteristics and differential diagnosis.
Berezowska S, Maillard M, Keyter M, Bisig B
Histopathology 2024 Jan;84(1):32-49. Epub 2023 Nov 7 doi: 10.1111/his.15076. PMID: 37936498
Outcomes after sublobar resection versus lobectomy in non-small cell carcinoma in situ.
Perez Holguin RA, Olecki EJ, Wong WG, Stahl KA, Go PH, Taylor MD, Reed MF, Shen C
J Thorac Cardiovasc Surg 2023 Mar;165(3):853-861.e3. Epub 2022 Jun 1 doi: 10.1016/j.jtcvs.2022.05.032. PMID: 35760619
Prognostic impact of tumor-infiltrating lymphocytes in non-small cell lung carcinomas.
Mlika M, Saidi A, Mejri N, Abdennadher M, Haddouchi C, Labidi S, Khiari H, Boussen H, Hsairi M, Mezni F
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):177-184. Epub 2021 Sep 24 doi: 10.1177/02184923211042129. PMID: 34558296
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705
Molecular and pathologic markers in stage I non-small-cell carcinoma of the lung.
Strauss GM, Kwiatkowski DJ, Harpole DH, Lynch TJ, Skarin AT, Sugarbaker DJ
J Clin Oncol 1995 May;13(5):1265-79. doi: 10.1200/JCO.1995.13.5.1265. PMID: 7738631

Diagnosis

Pulmonary squamous cell carcinoma and lymphoepithelial carcinoma - morphology, molecular characteristics and differential diagnosis.
Berezowska S, Maillard M, Keyter M, Bisig B
Histopathology 2024 Jan;84(1):32-49. Epub 2023 Nov 7 doi: 10.1111/his.15076. PMID: 37936498
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article
Bronchial carcinosarcoma.
Carcano C, Savage E, Diacovo MJ, Kirsch J
J Radiol Case Rep 2012 Oct;6(10):26-31. Epub 2012 Oct 1 doi: 10.3941/jrcr.v6i10.1049. PMID: 23378874Free PMC Article
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Therapy

Small molecule TKI inhibitors affect the development of non-small cell carcinoma through HIPPO/YAP/PD-L1.
Lei L, Weidong Z
Cell Mol Biol (Noisy-le-grand) 2022 Feb 4;67(5):117-122. doi: 10.14715/cmb/2021.67.5.16. PMID: 35818263
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer.
Subramaniyan V, Fuloria S, Gupta G, Kumar DH, Sekar M, Sathasivam KV, Sudhakar K, Alharbi KS, Al-Malki WH, Afzal O, Kazmi I, Al-Abbasi FA, Altamimi ASA, Fuloria NK
Chem Biol Interact 2022 Jan 5;351:109735. Epub 2021 Nov 3 doi: 10.1016/j.cbi.2021.109735. PMID: 34742684
Radiotherapy treatment for lung cancer: Current status and future directions.
Vinod SK, Hau E
Respirology 2020 Nov;25 Suppl 2:61-71. Epub 2020 Jun 9 doi: 10.1111/resp.13870. PMID: 32516852
An update on the developing mitotic inhibitors for the treatment of non-small cell carcinoma.
Sacco PC, Gridelli C
Expert Opin Emerg Drugs 2017 Sep;22(3):213-222. doi: 10.1080/14728214.2017.1369952. PMID: 28836854
Emerging mitotic inhibitors for non-small cell carcinoma.
Casaluce F, Sgambato A, Maione P, Ciardiello F, Gridelli C
Expert Opin Emerg Drugs 2013 Mar;18(1):97-107. doi: 10.1517/14728214.2013.777426. PMID: 23448156

Prognosis

Prognostic impact of tumor-infiltrating lymphocytes in non-small cell lung carcinomas.
Mlika M, Saidi A, Mejri N, Abdennadher M, Haddouchi C, Labidi S, Khiari H, Boussen H, Hsairi M, Mezni F
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):177-184. Epub 2021 Sep 24 doi: 10.1177/02184923211042129. PMID: 34558296
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article
Bronchial carcinosarcoma.
Carcano C, Savage E, Diacovo MJ, Kirsch J
J Radiol Case Rep 2012 Oct;6(10):26-31. Epub 2012 Oct 1 doi: 10.3941/jrcr.v6i10.1049. PMID: 23378874Free PMC Article
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Clinical prediction guides

Deep immune B and plasma cell repertoire in non-small cell lung cancer.
Patel AJ, Khan N, Richter A, Naidu B, Drayson MT, Middleton GW
Front Immunol 2023;14:1198665. Epub 2023 Jun 15 doi: 10.3389/fimmu.2023.1198665. PMID: 37398676Free PMC Article
Xanthorrhizol inhibits non-small cell carcinoma (A549) cell growth and promotes apoptosis through modulation of PI3K/AKT and NF-κB signaling pathway.
Cai Y, Sheng Z, Wang J
Environ Toxicol 2022 Jan;37(1):120-130. Epub 2021 Oct 18 doi: 10.1002/tox.23383. PMID: 34664399
Prognostic impact of tumor-infiltrating lymphocytes in non-small cell lung carcinomas.
Mlika M, Saidi A, Mejri N, Abdennadher M, Haddouchi C, Labidi S, Khiari H, Boussen H, Hsairi M, Mezni F
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):177-184. Epub 2021 Sep 24 doi: 10.1177/02184923211042129. PMID: 34558296
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Molecular and pathologic markers in stage I non-small-cell carcinoma of the lung.
Strauss GM, Kwiatkowski DJ, Harpole DH, Lynch TJ, Skarin AT, Sugarbaker DJ
J Clin Oncol 1995 May;13(5):1265-79. doi: 10.1200/JCO.1995.13.5.1265. PMID: 7738631

Recent systematic reviews

Lymphovascular invasion as a prognostic indicator in stage I non-small cell lung cancer: a systematic review and meta-analysis.
Mollberg NM, Bennette C, Howell E, Backhus L, Devine B, Ferguson MK
Ann Thorac Surg 2014 Mar;97(3):965-71. Epub 2014 Jan 11 doi: 10.1016/j.athoracsur.2013.11.002. PMID: 24424014
Palinacousis--evidence to suggest a post-ictal phenomenon.
Mohamed W, Ahuja N, Shah A
J Neurol Sci 2012 Jun 15;317(1-2):6-12. Epub 2012 Mar 11 doi: 10.1016/j.jns.2012.02.016. PMID: 22414800

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